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Paul Rejto
Paul Rejto
Executive Director, Translational Research, Pfizer
Verified email at pfizer.com
Title
Cited by
Cited by
Year
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
K Wang, ST Yuen, J Xu, SP Lee, HHN Yan, ST Shi, HC Siu, S Deng, ...
Nature genetics 46 (6), 573-582, 2014
10782014
Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programming
DK Gehlhaar, GM Verkhivker, PA Rejto, CJ Sherman, DR Fogel, LJ Fogel, ...
Chemistry & biology 2 (5), 317-324, 1995
8931995
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
K Wang, J Kan, ST Yuen, ST Shi, KM Chu, S Law, TL Chan, Z Kan, ...
Nature genetics 43 (12), 1219-1223, 2011
8572011
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
Z Kan, H Zheng, X Liu, S Li, TD Barber, Z Gong, H Gao, K Hao, ...
Genome research 23 (9), 1422-1433, 2013
5602013
Deciphering common failures in molecular docking of ligand-protein complexes
GM Verkhivker, D Bouzida, DK Gehlhaar, PA Rejto, S Arthurs, AB Colson, ...
Journal of computer-aided molecular design 14, 731-751, 2000
3032000
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma
K Wang, HY Lim, S Shi, J Lee, S Deng, T Xie, Z Zhu, Y Wang, D Pocalyko, ...
Hepatology 58 (2), 706-717, 2013
1902013
PEST domain mutations in Notch receptors comprise an oncogenic driver segment in triple-negative breast cancer sensitive to a γ-secretase inhibitor
K Wang, Q Zhang, D Li, K Ching, C Zhang, X Zheng, M Ozeck, S Shi, X Li, ...
Clinical cancer research 21 (6), 1487-1496, 2015
1682015
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine …
PS Dragovich, TJ Prins, R Zhou, SE Webber, JT Marakovits, SA Fuhrman, ...
Journal of medicinal chemistry 42 (7), 1213-1224, 1999
1631999
Comparison of the molecular and cellular phenotypes of common mouse syngeneic models with human tumors
W Zhong, JS Myers, F Wang, K Wang, J Lucas, E Rosfjord, J Lucas, ...
Bmc Genomics 21, 1-17, 2020
1312020
Complexity and simplicity of ligand–macromolecule interactions: the energy landscape perspective
GM Verkhivker, D Bouzida, DK Gehlhaar, PA Rejto, ST Freer, PW Rose
Current opinion in structural biology 12 (2), 197-203, 2002
1292002
Docking conformationally flexible small molecules into a protein binding site through evolutionary programming
DK Gehlhaar, G Verkhivker, PA Rejto, DB Fogel, LJ Fogel, ST Freer
1291995
An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735
KE Hook, SJ Garza, ME Lira, KA Ching, NV Lee, J Cao, J Yuan, J Ye, ...
Molecular cancer therapeutics 11 (3), 710-719, 2012
1182012
A novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis
IJ Bujalska, LL Gathercole, JW Tomlinson, C Darimont, J Ermolieff, ...
The Journal of endocrinology 197 (2), 297, 2008
1162008
Simulating disorder–order transitions in molecular recognition of unstructured proteins: where folding meets binding
GM Verkhivker, D Bouzida, DK Gehlhaar, PA Rejto, ST Freer, PW Rose
Proceedings of the National Academy of Sciences 100 (9), 5148-5153, 2003
1162003
Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics
CR Kissinger, PA Rejto, LA Pelletier, JA Thomson, RE Showalter, ...
Journal of molecular biology 342 (3), 943-952, 2004
1152004
Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome
YH Park, S Lal, JE Lee, YL Choi, J Wen, S Ram, Y Ding, SH Lee, E Powell, ...
Nature communications 11 (1), 6175, 2020
1082020
Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Vivo Limits Glucocorticoid Exposure to Human Adipose Tissue and Decreases Lipolysis
JW Tomlinson, M Sherlock, B Hughes, SV Hughes, F Kilvington, W Bartlett, ...
The Journal of Clinical Endocrinology & Metabolism 92 (3), 857-864, 2007
1052007
Unraveling principles of lead discovery: from unfrustrated energy landscapes to novel molecular anchors.
PA Rejto, GM Verkhivker
Proceedings of the National Academy of Sciences 93 (17), 8945-8950, 1996
971996
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2 …
PS Dragovich, TJ Prins, R Zhou, TO Johnson, Y Hua, HT Luu, SK Sakata, ...
Journal of medicinal chemistry 46 (21), 4572-4585, 2003
932003
A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations
T Xie, G d’Ario, JR Lamb, E Martin, K Wang, S Tejpar, M Delorenzi, ...
Public Library of Science 7 (7), e42001, 2012
922012
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