| TNF-α converting enzyme (TACE) is inhibited by TIMP-3 A Amour, PM Slocombe, A Webster, M Butler, CG Knight, BJ Smith, ... FEBS letters 435 (1), 39-44, 1998 | 826 | 1998 |
| The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3 A Amour, CG Knight, A Webster, PM Slocombe, PE Stephens, V Knäuper, ... FEBS letters 473 (3), 275-279, 2000 | 532 | 2000 |
| Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-α convertase activity but does not activate pro-MMP2 WR English, XS Puente, JMP Freije, V Knäuper, A Amour, ... Journal of Biological Chemistry 275 (19), 14046-14055, 2000 | 288 | 2000 |
| Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase Z Scholefield, EA Yates, G Wayne, A Amour, W McDowell, JE Turnbull The Journal of cell biology 163 (1), 97-107, 2003 | 214 | 2003 |
| The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs A Amour, CG Knight, WR English, A Webster, PM Slocombe, V Knäuper, ... FEBS letters 524 (1-3), 154-158, 2002 | 185 | 2002 |
| Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus: metalloproteinase inhibition is associated with proapoptotic activity M Bond, G Murphy, MR Bennett, A Amour, V Knäuper, AC Newby, ... Journal Of Biological Chemistry 275 (52), 41358-41363, 2000 | 143 | 2000 |
| Acute respiratory distress syndrome neutrophils have a distinct phenotype and are resistant to phosphoinositide 3-kinase inhibition JK Juss, D House, A Amour, M Begg, J Herre, DML Storisteanu, ... American journal of respiratory and critical care medicine 194 (8), 961-973, 2016 | 135 | 2016 |
| Optimization of novel indazoles as highly potent and selective inhibitors of phosphoinositide 3-kinase δ for the treatment of respiratory disease K Down, A Amour, IR Baldwin, AWJ Cooper, AM Deakin, LM Felton, ... Journal of medicinal chemistry 58 (18), 7381-7399, 2015 | 130 | 2015 |
| Enzyme accessibility and solid supports: which molecular weight enzymes can be used on solid supports? An investigation using confocal Raman microscopy J Kress, R Zanaletti, A Amour, M Ladlow, JG Frey, M Bradley Chemistry–A European Journal 8 (16), 3769-3772, 2002 | 114 | 2002 |
| ADAM28 is overexpressed in human non‐small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis T Ohtsuka, T Shiomi, M Shimoda, T Kodama, A Amour, G Murphy, ... International journal of cancer 118 (2), 263-273, 2006 | 113 | 2006 |
| TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4 GJ Wayne, SJ Deng, A Amour, S Borman, R Matico, HL Carter, G Murphy Journal of Biological Chemistry 282 (29), 20991-20998, 2007 | 83 | 2007 |
| Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis: the specificity is in the detail G Murphy, V Knäuper, MH Lee, A Amour, JR Worley, M Hutton, S Atkinson, ... Biochemical Society Symposia 70, 65-80, 2003 | 83 | 2003 |
| Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE … SJF Macdonald, MD Dowle, LA Harrison, GDE Clarke, GGA Inglis, ... Journal of medicinal chemistry 45 (18), 3878-3890, 2002 | 81 | 2002 |
| The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate SJF Macdonald, MD Dowle, LA Harrison, P Shah, MR Johnson, ... Bioorganic & medicinal chemistry letters 11 (7), 895-898, 2001 | 71 | 2001 |
| Study of bradykinin metabolism in human and rat plasma by liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time‐of‐flight … P Marshall, O Heudi, S Mckeown, A Amour, F Abou‐Shakra Rapid communications in mass spectrometry 16 (3), 220-228, 2002 | 63 | 2002 |
| Targeting phosphoinositide 3‐kinase δ for the treatment of respiratory diseases S Sriskantharajah, N Hamblin, S Worsley, AR Calver, EM Hessel, ... Annals of the new York Academy of Sciences 1280 (1), 35-39, 2013 | 61 | 2013 |
| Design and synthesis of hydrazinopeptides and their evaluation as human leukocyte elastase inhibitors L Guy, J Vidal, A Collet, A Amour, M Reboud-Ravaux Journal of medicinal chemistry 41 (24), 4833-4843, 1998 | 61 | 1998 |
| Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-α-converting enzyme MH Lee, V Verma, K Maskos, D Nath, V Knäuper, P Dodds, A Amour, ... Biochemical Journal 364 (1), 227-234, 2002 | 59 | 2002 |
| A broad‐spectrum fluorescence‐based peptide library for the rapid identification of protease substrates DA Thomas, P Francis, C Smith, S Ratcliffe, NJ Ede, C Kay, G Wayne, ... Proteomics 6 (7), 2112-2120, 2006 | 58 | 2006 |
| Targeting phosphoinositide 3-kinase δ for allergic asthma WC Rowan, JL Smith, K Affleck, A Amour Biochemical Society Transactions 40 (1), 240-245, 2012 | 52 | 2012 |
Edith M HesselChief Scientific Officer at Relation TherapeuticsVerified email at relationrx.com
