| Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis T Ryckmans, MP Edwards, VA Horne, AM Correia, DR Owen, ... Bioorganic & medicinal chemistry letters 19 (15), 4406-4409, 2009 | 295 | 2009 |
| Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa R Sommer, S Wagner, K Rox, A Varrot, D Hauck, EC Wamhoff, ... Journal of the American Chemical Society 140 (7), 2537-2545, 2018 | 116 | 2018 |
| First dual NK1 antagonists–serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants T Ryckmans, L Balançon, O Berton, C Genicot, Y Lamberty, B Lallemand, ... Bioorganic & Medicinal Chemistry Letters 12 (2), 261-264, 2002 | 114 | 2002 |
| The discovery of a potent, selective, and peripherally restricted pan-Trk inhibitor (PF-06273340) for the treatment of pain SE Skerratt, M Andrews, SK Bagal, J Bilsland, D Brown, PJ Bungay, ... Journal of Medicinal Chemistry 59 (22), 10084-10099, 2016 | 75 | 2016 |
| Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure–Activity Relationship Study of C-Glycosidic LecB Inhibitors R Sommer, K Rox, S Wagner, D Hauck, SS Henrikus, S Newsad, T Arnold, ... Journal of medicinal chemistry 62 (20), 9201-9216, 2019 | 54 | 2019 |
| Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel T Ryckmans, AA Aubdool, JV Bodkin, P Cox, SD Brain, T Dupont, ... Bioorganic & medicinal chemistry letters 21 (16), 4857-4859, 2011 | 50 | 2011 |
| Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition PV Fish, C Deur, X Gan, K Greene, D Hoople, M Mackenny, KS Para, ... Bioorganic & medicinal chemistry letters 18 (8), 2562-2566, 2008 | 44 | 2008 |
| Dual NK1 antagonists—serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives T Ryckmans, O Berton, R Grimée, T Kogej, Y Lamberty, P Pasau, ... Bioorganic & medicinal chemistry letters 12 (21), 3195-3198, 2002 | 43 | 2002 |
| Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study A Wijeyesekera, PA Clarke, M Bictash, IJ Brown, M Fidock, T Ryckmans, ... Analytical methods 4 (1), 65-72, 2012 | 42 | 2012 |
| Application of Barluenga Boronic Coupling (BBC) to the Parallel Synthesis of Drug‐like and Drug Fragment‐like Molecules S Nakagawa, KA Bainbridge, K Butcher, D Ellis, W Klute, T Ryckmans ChemMedChem 7 (2), 233, 2012 | 41 | 2012 |
| Chemical compounds AD Brown, MJ De Groot, BE Marron, DJ Rawson, T Ryckmans, RI Storer, ... US Patent 8,772,293, 2014 | 39 | 2014 |
| Triazolyl piperidine arginine vasopressin receptor modulators JS Bryans, PS Johnson, LR Roberts, T Ryckmans US Patent 7,745,630, 2010 | 38 | 2010 |
| Modulation of the vasopressin system for the treatment of CNS diseases. T Ryckmans Current opinion in drug discovery & development 13 (5), 538-547, 2010 | 34 | 2010 |
| Triazole compounds useful in therapy RD Armour, AD Baxter, JS Bryans, KN Dack, PS Johnson, RA Lewthwaite, ... US Patent 7,084,145, 2006 | 32 | 2006 |
| A concise total synthesis of the lichen macrolide (+)-aspicilin C Dubost, IE Marko, T Ryckmans Organic letters 8 (22), 5137-5140, 2006 | 31 | 2006 |
| Highly potent and selective NaV1. 7 inhibitors for use as intravenous agents and chemical probes RI Storer, A Pike, NA Swain, AJ Alexandrou, BM Bechle, DC Blakemore, ... Bioorganic & Medicinal Chemistry Letters 27 (21), 4805-4811, 2017 | 29 | 2017 |
| TAK 1 Inhibition in the DFG‐Out Conformation I Kilty, MP Green, AS Bell, DG Brown, PG Dodd, C Hewson, SJ Hughes, ... Chemical biology & drug design 82 (5), 500-505, 2013 | 22 | 2013 |
| Identification of novel scaffolds targeting Mycobacterium tuberculosis M Dal Molin, P Selchow, D Schäfle, A Tschumi, T Ryckmans, S Laage-Witt, ... Journal of Molecular Medicine 97, 1601-1613, 2019 | 20 | 2019 |
| SAR mining and its application to the design of TRPA1 antagonists JEJ Mills, AD Brown, T Ryckmans, DC Miller, SE Skerratt, CM Barker, ... MedChemComm 3 (2), 174-178, 2012 | 20 | 2012 |
| Pyrrolo [2, 3-d] pyrimidine derivatives as inhibitors of tropomyosin-related kinases and their preparation and use in the treatment of pain MD Andrews, SK Bagal, KR Gibson, K Omoto, T Ryckmans, SE Skerratt, ... WO2012137089, 2012 | 18 | 2012 |
