Oliver J. Britton
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Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology
OJ Britton, A Bueno-Orovio, K Van Ammel, HR Lu, R Towart, DJ Gallacher, ...
Proceedings of the National Academy of Sciences 110 (23), E2098-E2105, 2013
Defining the limits of single-molecule FRET resolution in TIRF microscopy
SJ Holden, S Uphoff, J Hohlbein, D Yadin, L Le Reste, OJ Britton, ...
Biophysical journal 99 (9), 3102-3111, 2010
Human in silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity
E Passini, OJ Britton, HR Lu, J Rohrbacher, AN Hermans, DJ Gallacher, ...
Frontiers in Physiology 8, 668, 2017
Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm
A Muszkiewicz, OJ Britton, P Gemmell, E Passini, C Sánchez, X Zhou, ...
Progress in biophysics and molecular biology 120 (1), 115-127, 2016
Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop
B Rodriguez, A Carusi, N Abi-Gerges, R Ariga, O Britton, G Bub, ...
EP Europace 18 (9), 1287-1298, 2015
The Electrogenic Na+/K+ pump is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study
OJ Britton, A Bueno-Orovio, L Virág, A Varró, B Rodriguez
Frontiers in physiology 8, 2017
Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter …
OJ Britton, N Abi-Gerges, G Page, A Ghetti, PE Miller, B Rodriguez
Frontiers in Physiology 8, 597, 2017
Experimentally-based computational investigation into beat-to-beat variability in ventricular repolarization and its response to ionic current inhibition
E Pueyo, CE Dangerfield, OJ Britton, L Virág, K Kistamás, ...
PloS one 11 (3), e0151461, 2016
Effect of inter-subject variability in determining response to IKr block in human ventricular myocytes
OJ Britton, A Bueno-Orovio, L Virag, A Varro, B Rodriguez
Computing in Cardiology Conference (CinC), 2014, 869-872, 2014
Virtual assay: A user-friendly framework for in silico drug trials in populations of human cardiomyocyte models
E Passini, OJ Britton, RJH Greig, A Bueno-Orovio, B Rodriguez
Journal of Pharmacological and Toxicological Methods 93, 145, 2018
Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition (vol 11, e0151461, 2016)
E Pueyo, CE Dangerfield, OJ Britton, L Virag, K Kistamas, ...
PLOS ONE 13 (5), 2018
Investigation of Inter-individual Variability in Electrophysiological Response to Drug Block Using Human Ex Vivo Ventricular Preparations and Heart-specific Populations of …
O Britton, G Page, P Ratchada, Y Miron, P Miller, A Ghetti, N Abi-Gerges, ...
Journal of Pharmacological and Toxicological Methods 88, 202-203, 2017
In Silico Drug Trials with Virtual Assay Software Predict Drug Cardiotoxicity and Identify Sub-Populations at Higher Risk
E Passini, O Britton, A Bueno-Orovio, B Rodriguez
Journal of Pharmacological and Toxicological Methods 88, 208-209, 2017
In silico prediction of drug effects on human ventricular electrophysiology using the Virtual Assay software and comparison to in vitro data
E Passini, O Britton, HR Lu, DJ Gallacher, J Rohrbacher, H An, ...
Journal of Pharmacological and Toxicological Methods, 345-346, 2016
Combined experimental and computational investigation into inter-subject variability in cardiac electrophysiology
OJ Britton
University of Oxford, 2015
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