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Nigel Scrutton
Nigel Scrutton
Professor of Enzymology, Manchester Institute of Biotechnology (MIB) and School of Chemistry
Verified email at manchester.ac.uk - Homepage
Title
Cited by
Cited by
Year
Redesign of the coenzyme specificity of a dehydrogenase by protein engineering
NS Scrutton, A Berry, RN Perham
Nature 343 (6253), 38-43, 1990
9021990
Atomic description of an enzyme reaction dominated by proton tunneling
L Masgrau, A Roujeinikova, LO Johannissen, P Hothi, J Basran, ...
Science 312 (5771), 237-241, 2006
4052006
Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades
FG Mutti, T Knaus, NS Scrutton, M Breuer, NJ Turner
Science 349 (6255), 1525-1529, 2015
3822015
Biocatalytic reductions and chemical versatility of the old yellow enzyme family of flavoprotein oxidoreductases
HS Toogood, JM Gardiner, NS Scrutton
ChemCatChem 2 (8), 892-914, 2010
3192010
Cation-π bonding and amino-aromatic interactions in the biomolecular recognition of substituted ammonium ligands
NS Scrutton, ARC Raine
Biochemical Journal 319 (1), 1-8, 1996
3091996
Good vibrations in enzyme-catalysed reactions
S Hay, NS Scrutton
Nature chemistry 4 (3), 161-168, 2012
2972012
Enzymatic H-transfer requires vibration-driven extreme tunneling
J Basran, MJ Sutcliffe, NS Scrutton
Biochemistry 38 (10), 3218-3222, 1999
2841999
Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: the current state of affairs
M Mewies, WS McIntire, NS Scrutton
Protein Science 7 (1), 7-20, 1998
2681998
Building a global alliance of biofoundries
N Hillson, M Caddick, Y Cai, JA Carrasco, MW Chang, NC Curach, ...
Nature communications 10 (1), 2040, 2019
2442019
Biotransformation of explosives by the old yellow enzyme family of flavoproteins
RE Williams, DA Rathbone, NS Scrutton, NC Bruce
Applied and environmental microbiology 70 (6), 3566-3574, 2004
2232004
New cofactor supports α, β-unsaturated acid decarboxylation via 1, 3-dipolar cycloaddition
KAP Payne, MD White, K Fisher, B Khara, SS Bailey, D Parker, ...
Nature 522 (7557), 497-501, 2015
2182015
Discovery, characterization, engineering, and applications of ene-reductases for industrial biocatalysis
HS Toogood, NS Scrutton
ACS catalysis 8 (4), 3532-3549, 2018
2112018
What’s in a covalent bond? On the role and formation of covalently bound flavin cofactors
DPHM Heuts, NS Scrutton, WS McIntire, MW Fraaije
The FEBS journal 276 (13), 3405-3427, 2009
2062009
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals
P Carbonell, AJ Jervis, CJ Robinson, C Yan, M Dunstan, N Swainston, ...
Communications biology 1 (1), 66, 2018
2002018
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis
MD White, KAP Payne, K Fisher, SA Marshall, D Parker, NJW Rattray, ...
Nature 522 (7557), 502-506, 2015
1872015
Better than nature: nicotinamide biomimetics that outperform natural coenzymes
T Knaus, CE Paul, CW Levy, S De Vries, FG Mutti, F Hollmann, ...
Journal of the American Chemical Society 138 (3), 1033-1039, 2016
1672016
Biodiversity of cytochrome P450 redox systems
KJ McLean, M Sabri, KR Marshall, RJ Lawson, DG Lewis, D Clift, ...
Biochemical Society Transactions 33 (4), 796-801, 2005
1672005
A new conceptual framework for enzyme catalysis: Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes
MJ Sutcliffe, NS Scrutton
European Journal of Biochemistry 269 (13), 3096-3102, 2002
1652002
The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase
R Neeli, HM Girvan, A Lawrence, MJ Warren, D Leys, NS Scrutton, ...
FEBS letters 579 (25), 5582-5588, 2005
1552005
New developments in ‘ene’-reductase catalysed biological hydrogenations
HS Toogood, NS Scrutton
Current opinion in chemical biology 19, 107-115, 2014
1542014
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