| Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission LC Greaves, SL Preston, PJ Tadrous, RW Taylor, MJ Barron, D Oukrif, ... Proceedings of the National Academy of Sciences 103 (3), 714-719, 2006 | 306 | 2006 |
| Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells SAC McDonald, LC Greaves, L Gutierrez–Gonzalez, M Rodriguez–Justo, ... Gastroenterology 134 (2), 500-510, 2008 | 264 | 2008 |
| Detection of intestinal metaplasia in Barrett's esophagus: an observational comparator study suggests the need for a minimum of eight biopsies R Harrison, I Perry, W Haddadin, S McDonald, R Bryan, K Abrams, ... Official journal of the American College of Gastroenterology| ACG 102 (6 …, 2007 | 251 | 2007 |
| Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett’s oesophagus SJ Leedham, SL Preston, SAC McDonald, G Elia, P Bhandari, D Poller, ... Gut 57 (8), 1041-1048, 2008 | 238 | 2008 |
| Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion … LM Higgins, SAC McDonald, N Whittle, N Crockett, JG Shields, ... The Journal of Immunology 162 (1), 486-493, 1999 | 232 | 1999 |
| Quantification of crypt and stem cell evolution in the normal and neoplastic human colon AM Baker, B Cereser, S Melton, AG Fletcher, M Rodriguez-Justo, ... Cell reports 8 (4), 940-947, 2014 | 206 | 2014 |
| Intestinal stem cells SJ Leedham, M Brittan, SAC McDonald, NA Wright Journal of cellular and molecular medicine 9 (1), 11-24, 2005 | 200 | 2005 |
| Clonality, founder mutations, and field cancerization in human ulcerative colitis–associated neoplasia SJ Leedham, TA Graham, D Oukrif, SAC McDonald, M Rodriguez–Justo, ... Gastroenterology 136 (2), 542-550. e6, 2009 | 187 | 2009 |
| Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway PJ Pollard, B Spencer-Dene, D Shukla, K Howarth, E Nye, M El-Bahrawy, ... Cancer cell 11 (4), 311-319, 2007 | 182 | 2007 |
| Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread PP Wong, F Demircioglu, E Ghazaly, W Alrawashdeh, MRL Stratford, ... Cancer cell 27 (1), 123-137, 2015 | 181 | 2015 |
| Locating the stem cell niche and tracing hepatocyte lineages in human liver TG Fellous, S Islam, PJ Tadrous, G Elia, HM Kocher, S Bhattacharya, ... Hepatology 49 (5), 1655-1663, 2009 | 179 | 2009 |
| Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas C Thirlwell, OCC Will, E Domingo, TA Graham, SAC McDonald, D Oukrif, ... Gastroenterology 138 (4), 1441-1454. e7, 2010 | 156 | 2010 |
| Mechanisms of disease: from stem cells to colorectal cancer SAC McDonald, SL Preston, MJ Lovell, NA Wright, JAZ Jankowski Nature clinical practice Gastroenterology & hepatology 3 (5), 267-274, 2006 | 123 | 2006 |
| Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors VH Teixeira, P Nadarajan, TA Graham, CP Pipinikas, JM Brown, M Falzon, ... Elife 2, 2013 | 113 | 2013 |
| Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis S Galandiuk, M Rodriguez–Justo, R Jeffery, AM Nicholson, Y Cheng, ... Gastroenterology 142 (4), 855-864. e8, 2012 | 105 | 2012 |
| The clonal origins of dysplasia from intestinal metaplasia in the human stomach L Gutierrez–Gonzalez, TA Graham, M Rodriguez–Justo, SJ Leedham, ... Gastroenterology 140 (4), 1251-1260. e6, 2011 | 104 | 2011 |
| The histogenesis of regenerative nodules in human liver cirrhosis WR Lin, SN Lim, SAC McDonald, T Graham, VL Wright, CL Peplow, ... Hepatology 51 (3), 1017-1026, 2010 | 101 | 2010 |
| Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution A Humphries, B Cereser, LJ Gay, DSJ Miller, B Das, A Gutteridge, G Elia, ... Proceedings of the National Academy of Sciences 110 (27), E2490-E2499, 2013 | 100 | 2013 |
| Characterization of the mucosal cell‐mediated immune response in IL‐2 knockout mice before and after the onset of colitis SAC McDonald, M Palmen, EP Van Rees, TT MacDonald Immunology 91 (1), 73-80, 1997 | 89 | 1997 |
| Evolutionary history of human colitis-associated colorectal cancer AM Baker, W Cross, K Curtius, I Al Bakir, CHR Choi, HL Davis, D Temko, ... Gut 68 (6), 985-995, 2019 | 82 | 2019 |
Nicholas A WrightProfessor of Histopathology, Queen Mary University of LondonVerified email at qmul.ac.uk
