Stuart McDonald
Stuart McDonald
Senior Lecturer in Gastroenterology , Barts Cancer Institute, Barts and the London School of
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Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission
LC Greaves, SL Preston, PJ Tadrous, RW Taylor, MJ Barron, D Oukrif, ...
Proceedings of the National Academy of Sciences 103 (3), 714-719, 2006
Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells
SAC McDonald, LC Greaves, L Gutierrez–Gonzalez, M Rodriguez–Justo, ...
Gastroenterology 134 (2), 500-510, 2008
Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion …
LM Higgins, SAC McDonald, N Whittle, N Crockett, JG Shields, ...
The Journal of Immunology 162 (1), 486-493, 1999
Detection of intestinal metaplasia in Barrett's esophagus: an observational comparator study suggests the need for a minimum of eight biopsies
R Harrison, I Perry, W Haddadin, S McDonald, R Bryan, K Abrams, ...
American Journal of Gastroenterology 102 (6), 1154-1161, 2007
Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett’s oesophagus
SJ Leedham, SL Preston, SAC McDonald, G Elia, P Bhandari, D Poller, ...
Gut 57 (8), 1041-1048, 2008
Intestinal stem cells
SJ Leedham, M Brittan, SAC McDonald, NA Wright
Journal of cellular and molecular medicine 9 (1), 11-24, 2005
Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway
PJ Pollard, B Spencer-Dene, D Shukla, K Howarth, E Nye, M El-Bahrawy, ...
Cancer cell 11 (4), 311-319, 2007
Quantification of crypt and stem cell evolution in the normal and neoplastic human colon
AM Baker, B Cereser, S Melton, AG Fletcher, M Rodriguez-Justo, ...
Cell reports 8 (4), 940-947, 2014
Locating the stem cell niche and tracing hepatocyte lineages in human liver
TG Fellous, S Islam, PJ Tadrous, G Elia, HM Kocher, S Bhattacharya, ...
Hepatology 49 (5), 1655-1663, 2009
Clonality, founder mutations, and field cancerization in human ulcerative colitis–associated neoplasia
SJ Leedham, TA Graham, D Oukrif, SAC McDonald, M Rodriguez–Justo, ...
Gastroenterology 136 (2), 542-550. e6, 2009
Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread
PP Wong, F Demircioglu, E Ghazaly, W Alrawashdeh, MRL Stratford, ...
Cancer cell 27 (1), 123-137, 2015
Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas
C Thirlwell, OCC Will, E Domingo, TA Graham, SAC McDonald, D Oukrif, ...
Gastroenterology 138 (4), 1441-1454. e7, 2010
Mechanisms of disease: from stem cells to colorectal cancer
SAC McDonald, SL Preston, MJ Lovell, NA Wright, JAZ Jankowski
Nature Clinical Practice Gastroenterology & Hepatology 3 (5), 267-274, 2006
Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors
VH Teixeira, P Nadarajan, TA Graham, CP Pipinikas, JM Brown, M Falzon, ...
Elife 2, e00966, 2013
The clonal origins of dysplasia from intestinal metaplasia in the human stomach
L Gutierrez–Gonzalez, TA Graham, M Rodriguez–Justo, SJ Leedham, ...
Gastroenterology 140 (4), 1251-1260. e6, 2011
The histogenesis of regenerative nodules in human liver cirrhosis
WR Lin, SN Lim, SAC McDonald, T Graham, VL Wright, CL Peplow, ...
Hepatology 51 (3), 1017-1026, 2010
Characterization of the mucosal cell‐mediated immune response in IL‐2 knockout mice before and after the onset of colitis
SAC McDonald, M Palmen, EP Van Rees, TT MacDonald
Immunology 91 (1), 73-80, 1997
Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution
A Humphries, B Cereser, LJ Gay, DSJ Miller, B Das, A Gutteridge, G Elia, ...
Proceedings of the National Academy of Sciences 110 (27), E2490-E2499, 2013
Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis
S Galandiuk, M Rodriguez–Justo, R Jeffery, AM Nicholson, Y Cheng, ...
Gastroenterology 142 (4), 855-864. e8, 2012
Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo
A Milicic, LA Harrison, RA Goodlad, RG Hardy, AM Nicholson, M Presz, ...
Cancer research 68 (19), 7760-7768, 2008
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