James Mills
James Mills
Sandexis Medicinal Chemistry Ltd
Verified email at sandexis.co.uk
TitleCited byYear
Three-dimensional hydrogen-bond geometry and probability information from a crystal survey
JEJ Mills, PM Dean
Journal of computer-aided molecular design 10 (6), 607-622, 1996
2001996
Molecular surface-volume and property matching to superpose flexible dissimilar molecules
TDJ Perkins, JEJ Mills, PM Dean
Journal of Computer-Aided Molecular Design 9 (6), 479-490, 1995
691995
Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform
B Desai, K Dixon, E Farrant, Q Feng, KR Gibson, WP van Hoorn, J Mills, ...
Journal of medicinal chemistry 56 (7), 3033-3047, 2013
642013
High-throughput virtual screening of proteins using GRID molecular interaction fields
S Sciabola, RV Stanton, JE Mills, MM Flocco, M Baroni, G Cruciani, ...
Journal of chemical information and modeling 50 (1), 155-169, 2009
612009
Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs
AS Bell, JE Mills, GP Williams, JA Brannigan, AJ Wilkinson, T Parkinson, ...
PLoS neglected tropical diseases 6 (4), e1625, 2012
582012
Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics
WF Lau, JM Withka, D Hepworth, TV Magee, YJ Du, GA Bakken, ...
Journal of computer-aided molecular design 25 (7), 621, 2011
542011
Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE
IJP De Esch, JEJ Mills, TDJ Perkins, G Romeo, M Hoffmann, K Wieland, ...
Journal of medicinal chemistry 44 (11), 1666-1674, 2001
512001
Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE
IJP De Esch, JEJ Mills, TDJ Perkins, G Romeo, M Hoffmann, K Wieland, ...
Journal of medicinal chemistry 44 (11), 1666-1674, 2001
512001
Articles-Development of a Pharmacophore Model for Histamine H3 Receptor Antagonists, Using the Newly Developed Molecular Modeling Program SLATE
IJPD Esch, JEJ Mills, TDJ Perkins, G Romeo, M Hoffmann, K Wieland, ...
Journal of Medicinal Chemistry 44 (11), 1666-1674, 2001
51*2001
Enhanced HTS hit selection via a local hit rate analysis
BA Posner, H Xi, JEJ Mills
Journal of chemical information and modeling 49 (10), 2202-2210, 2009
442009
Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry
LH Jones, NW Summerhill, NA Swain, JE Mills
MedChemComm 1 (5), 309-318, 2010
412010
SLATE: a method for the superposition of flexible ligands
JEJ Mills, IJP De Esch, TDJ Perkins, PM Dean
Journal of Computer-Aided Molecular Design 15 (1), 81-96, 2001
392001
Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads
RO Oduor, KK Ojo, GP Williams, F Bertelli, J Mills, L Maes, DC Pryde, ...
PLoS neglected tropical diseases 5 (4), e1017, 2011
312011
Novel amino-pyrazole ureas with potent in vitro and in vivo antileishmanial activity
CE Mowbray, S Braillard, W Speed, PA Glossop, GA Whitlock, KR Gibson, ...
Journal of medicinal chemistry 58 (24), 9615-9624, 2015
282015
Novel oxindole sulfonamides and sulfamides: EPZ031686, the first orally bioavailable small molecule SMYD3 inhibitor
LH Mitchell, PA Boriack-Sjodin, S Smith, M Thomenius, N Rioux, ...
ACS medicinal chemistry letters 7 (2), 134-138, 2015
282015
An automated method for predicting the positions of hydrogen-bonding atoms in binding sites
JEJ Mills, TDJ Perkins, PM Dean
Journal of computer-aided molecular design 11 (3), 229-242, 1997
241997
Pyrazole NNRTIs 3: Optimisation of physicochemical properties
CE Mowbray, R Corbau, M Hawes, LH Jones, JE Mills, M Perros, ...
Bioorganic & medicinal chemistry letters 19 (19), 5603-5606, 2009
212009
CCR5 pharmacology methodologies and associated applications
R Mansfield, S Able, P Griffin, B Irvine, I James, M Macartney, K Miller, ...
Methods in enzymology 460, 17-55, 2009
192009
Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: Design, synthesis, and evaluation as topically applied, dermal anti-scarring …
S Bailey, PV Fish, S Billotte, J Bordner, D Greiling, K James, A McElroy, ...
Bioorganic & medicinal chemistry letters 18 (24), 6562-6567, 2008
182008
SAR mining and its application to the design of TRPA1 antagonists
JEJ Mills, AD Brown, T Ryckmans, DC Miller, SE Skerratt, CM Barker, ...
MedChemComm 3 (2), 174-178, 2012
172012
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Articles 1–20