John Heap
John Heap
School of Life Sciences, University of Nottingham
Verified email at - Homepage
Cited by
Cited by
The role of toxin A and toxin B in Clostridium difficile infection
SA Kuehne, ST Cartman, JT Heap, ML Kelly, A Cockayne, NP Minton
Nature 467 (7316), 711, 2010
The ClosTron: a universal gene knock-out system for the genus Clostridium
JT Heap, OJ Pennington, ST Cartman, GP Carter, NP Minton
Journal of microbiological methods 70 (3), 452-464, 2007
The ClosTron: mutagenesis in Clostridium refined and streamlined
JT Heap, SA Kuehne, M Ehsaan, ST Cartman, CM Cooksley, JC Scott, ...
Journal of microbiological methods 80 (1), 49-55, 2010
A modular system for Clostridium shuttle plasmids
JT Heap, OJ Pennington, ST Cartman, NP Minton
Journal of microbiological methods 78 (1), 79-85, 2009
Precise manipulation of the Clostridium difficile chromosome reveals a lack of association between the tcdC genotype and toxin production
ST Cartman, ML Kelly, D Heeg, JT Heap, NP Minton
Applied and environmental microbiology 78 (13), 4683-4690, 2012
Integration of DNA into bacterial chromosomes from plasmids without a counter-selection marker
JT Heap, M Ehsaan, CM Cooksley, YK Ng, ST Cartman, K Winzer, ...
Nucleic acids research 40 (8), e59-e59, 2012
The emergence of ‘hypervirulence’in Clostridium difficile
ST Cartman, JT Heap, SA Kuehne, A Cockayne, NP Minton
International Journal of Medical Microbiology 300 (6), 387-395, 2010
Multiple orphan histidine kinases interact directly with Spo0A to control the initiation of endospore formation in Clostridium acetobutylicum
E Steiner, AE Dago, DI Young, JT Heap, NP Minton, JA Hoch, M Young
Molecular microbiology 80 (3), 641-654, 2011
Review of NAD (P) H-dependent oxidoreductases: Properties, engineering and application
L Sellés, CL Kelly, PM Mordaka, JT Heap
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2017
SleC is essential for germination of Clostridium difficile spores in nutrient-rich medium supplemented with the bile salt taurocholate
DA Burns, JT Heap, NP Minton
Journal of bacteriology 192 (3), 657-664, 2010
The diverse sporulation characteristics of Clostridium difficile clinical isolates are not associated with type
DA Burns, JT Heap, NP Minton
Anaerobe 16 (6), 618-622, 2010
Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo
JT Heap, J Theys, M Ehsaan, AM Kubiak, L Dubois, K Paesmans, ...
Oncotarget 5 (7), 1761, 2014
Clostridium difficile spore germination: an update
DA Burns, JT Heap, NP Minton
Research in microbiology 161 (9), 730-734, 2010
ClosTron-Targeted Mutagenesis
JT Heap, ST Cartman, SA Kuehne, C Cooksley, NP Minton
Clostridium difficile, 165-182, 2010
ClosTron-targeted mutagenesis
JT Heap, ST Cartman, SA Kuehne, C Cooksley, NP Minton
Clostridium difficile, 165-182, 2010
Mutant generation by allelic exchange and genome resequencing of the biobutanol organism Clostridium acetobutylicum ATCC 824
M Ehsaan, W Kuit, Y Zhang, ST Cartman, JT Heap, K Winzer, NP Minton
Biotechnology for biofuels 9 (1), 1-20, 2016
Synthetic negative feedback circuits using engineered small RNAs
CL Kelly, AWK Harris, H Steel, EJ Hancock, JT Heap, ...
Nucleic acids research 46 (18), 9875-9889, 2018
A rhamnose-inducible system for precise and temporal control of gene expression in cyanobacteria
CL Kelly, GM Taylor, A Hitchcock, A Torres-Méndez, JT Heap
ACS synthetic biology 7 (4), 1056-1066, 2018
Secretion and assembly of functional mini-cellulosomes from synthetic chromosomal operons in Clostridium acetobutylicum ATCC 824
K Kovács, BJ Willson, K Schwarz, JT Heap, A Jackson, DN Bolam, ...
Biotechnology for biofuels 6 (1), 1-14, 2013
ClosTron-Mediated Engineering of Clostridium
SA Kuehne, JT Heap, CM Cooksley, ST Cartman, NP Minton
Strain Engineering, 389-407, 2011
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