Anthony G. Coyne
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Water: Nature’s Reaction Enforcer Comparative Effects for Organic Synthesis “In-Water” and “On-Water”
RN Butler, AG Coyne
Chemical reviews 110 (10), 6302-6337, 2010
Fragment-based approaches in drug discovery and chemical biology
DE Scott, AG Coyne, SA Hudson, C Abell
Biochemistry 51 (25), 4990-5003, 2012
Organic synthesis reactions on-water at the organic–liquid water interface
RN Butler, AG Coyne
Organic & biomolecular chemistry 14 (42), 9945-9960, 2016
The Influence of Water on the Rates of 1, 3-Dipolar Cycloaddition Reactions: Trigger Points for Exponential Rate Increases in Water− Organic Solvent Mixtures. Water-Super …
RN Butler, WJ Cunningham, AG Coyne, LA Burke
Journal of the American Chemical Society 126 (38), 11923-11929, 2004
Drugging challenging targets using fragment-based approaches
AG Coyne, DE Scott, C Abell
Current opinion in chemical biology 14 (3), 299-307, 2010
Trapping of palindromic ligands within native transthyretin prevents amyloid formation
SE Kolstoe, PP Mangione, V Bellotti, GW Taylor, GA Tennent, S Deroo, ...
Proceedings of the National Academy of Sciences 107 (47), 20483-20488, 2010
Asymmetric electrocyclic reactions
S Thompson, AG Coyne, PC Knipe, MD Smith
Chemical Society Reviews 40 (7), 4217-4231, 2011
The asymmetric synthesis of β-lactams: HETPHOX/Cu (I) mediated synthesis via the Kinugasa reaction
AG Coyne, H Müller-Bunz, PJ Guiry
Tetrahedron: Asymmetry 18 (2), 199-207, 2007
Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis
A Trapero, A Pacitto, V Singh, M Sabbah, AG Coyne, V Mizrahi, ...
Journal of medicinal chemistry 61 (7), 2806-2822, 2018
Water and organic synthesis: A focus on the in-water and on-water border. Reversal of the in-water Breslow hydrophobic enhancement of the normal endo-effect on crossing to on …
RN Butler, AG Coyne, WJ Cunningham, EM Moloney
The Journal of Organic Chemistry 78 (7), 3276-3291, 2013
Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors
ME Kavanagh, AG Coyne, KJ McLean, GG James, CW Levy, LB Marino, ...
Journal of medicinal chemistry 59 (7), 3272-3302, 2016
Understanding “On-Water” Catalysis of Organic Reactions. Effects of H+ and Li+ Ions in the Aqueous Phase and Nonreacting Competitor H-Bond Acceptors in the Organic Phase: On H …
RN Butler, AG Coyne
The Journal of Organic Chemistry 80 (3), 1809-1817, 2015
Effect of DMSO on protein structure and interactions assessed by collision-induced dissociation and unfolding
DSH Chan, ME Kavanagh, KJ McLean, AW Munro, D Matak-Vinković, ...
Analytical chemistry 89 (18), 9976-9983, 2017
Organic synthesis in water: 1, 3-dipolar cycloaddition reactions at ambient temperature with aqueous suspensions of solid reactants
RN Butler, AG Coyne, EM Moloney
Tetrahedron letters 48 (20), 3501-3503, 2007
Kinetic and synthetic influences of water and solvent-free conditions on 1, 3-dipolar cycloaddition reactions: the phthalazinium and pyridazinium dicyanomethanide 1, 3-dipoles …
RN Butler, AG Coyne, WJ Cunningham, LA Burke
Journal of the Chemical Society, Perkin Transactions 2, 1807-1815, 2002
Small‐Molecule Inhibitors That Target Protein–Protein Interactions in the RAD51 Family of Recombinases
DE Scott, AG Coyne, A Venkitaraman, TL Blundell, C Abell, M Hyvönen
ChemMedChem 10 (2), 296-303, 2015
Regioselectivity and endo/exo selectivity in the cycloadditions of the phthalazinium dicyanomethanide 1, 3-dipole with unsymmetrical alkene and alkyne dipolarophiles …
RN Butler, AG Coyne, P McArdle, D Cunningham, LA Burke
Journal of the Chemical Society, Perkin Transactions 1, 1391-1397, 2001
Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping
SE Thomas, P Collins, RH James, V Mendes, S Charoensutthivarakul, ...
Philosophical Transactions of the Royal Society A 377 (2147), 20180422, 2019
Overcoming the limitations of fragment merging: rescuing a strained merged fragment series targeting Mycobacterium tuberculosis CYP121
SA Hudson, S Surade, AG Coyne, KJ McLean, D Leys, AW Munro, ...
ChemMedChem 8 (9), 1451, 2013
Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches
AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, DSH Chan, ...
Journal of Medicinal Chemistry 62 (15), 7210-7232, 2019
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