Thomas D. Meek
Thomas D. Meek
Professor of Biochemistry & Biophysics, Texas A&M University
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TitleCited byYear
Identification of a novel aspartic protease (Asp 2) as β-secretase
I Hussain, D Powell, DR Howlett, DG Tew, TD Meek, C Chapman, ...
Molecular and Cellular Neuroscience 14 (6), 419-427, 1999
Drug–target residence time and its implications for lead optimization
RA Copeland, DL Pompliano, TD Meek
Nature reviews Drug discovery 5 (9), 730, 2006
Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor
C Debouck, JG Gorniak, JE Strickler, TD Meek, BW Metcalf, M Rosenberg
Proceedings of the National Academy of Sciences 84 (24), 8903-8906, 1987
Human immunodeficiency virus-1 protease. 2. Use of pH rate studies and solvent kinetic isotope effects to elucidate details of chemical mechanism
LJ Hyland, TA Tomaszek Jr, TD Meek
Biochemistry 30 (34), 8454-8463, 1991
Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues
TD Meek, DM Lambert, GB Dreyer, TJ Carr, TA Tomaszek, ML Moore, ...
Nature 343 (6253), 90, 1990
Inhibition of human immunodeficiency virus 1 protease in vitro: rational design of substrate analogue inhibitors
GB Dreyer, BW Metcalf, TA Tomaszek, TJ Carr, AC Chandler, L Hyland, ...
Proceedings of the National Academy of Sciences 86 (24), 9752-9756, 1989
Human immunodeficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric aspartic protease
TD Meek, BD Dayton, BW Metcalf, GB Dreyer, JE Strickler, JG Gorniak, ...
Proceedings of the National Academy of Sciences 86 (6), 1841-1845, 1989
ASP1 (BACE2) cleaves the amyloid precursor protein at the β-secretase site
I Hussain, DJ Powell, DR Howlett, GA Chapman, L Gilmour, PR Murdock, ...
Molecular and Cellular Neuroscience 16 (5), 609-619, 2000
Peptide substrates and inhibitors of the HIV-1 protease
ML Moore, WM Bryan, SA Fakhoury, VW Magaard, WF Huffman, ...
Biochemical and biophysical research communications 159 (2), 420-425, 1989
4-Aryl-1, 2, 3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo
LS Kallander, Q Lu, W Chen, T Tomaszek, G Yang, D Tew, TD Meek, ...
Journal of medicinal chemistry 48 (18), 5644-5647, 2005
Inhibitors of HIV-1 protease
TD Meek
Journal of enzyme inhibition 6 (1), 65-98, 1992
Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays
GB Dreyer, DM Lambert, TD Meek, TJ Carr, TA Tomaszek Jr, ...
Biochemistry 31 (29), 6646-6659, 1992
Human immunodeficiency virus-1 protease. 1. Initial velocity studies and kinetic characterization of reaction intermediates by oxygen-18 isotope exchange
LJ Hyland, TA Tomaszek Jr, GD Roberts, SA Carr, VW Magaard, ...
Biochemistry 30 (34), 8441-8453, 1991
Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica
TD Meek, EP Garvey, DV Santi
Biochemistry 24 (3), 678-686, 1985
A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa
CE Garrett, JA Coderre, TD Meek, EP Garvey, DM Claman, SM Beverley, ...
Molecular and biochemical parasitology 11, 257-265, 1984
Mass spectrometry
AL Burlingame, TA Baillie, DH Russell
Analytical chemistry 64 (12), 467-502, 1992
Effect of hydroxyl group configuration in hydroxyethylamine dipeptide isosteres on HIV protease inhibition. Evidence for multiple binding modes
DH Rich, CQ Sun, JVNV Prasad, A Pathiasseril, MV Toth, GR Marshall, ...
Journal of medicinal chemistry 34 (3), 1222-1225, 1991
Kinetic mechanism of Escherichia coli glutamine synthetase
TD Meek, JJ Villafranca
Biochemistry 19 (24), 5513-5519, 1980
Use of protein unfolding studies to determine the conformational and dimeric stabilities of HIV-1 and SIV proteases
SK Grant, IC Deckman, JS Culp, MD Minnich, IS Brooks, P Hensley, ...
Biochemistry 31 (39), 9491-9501, 1992
Novel receptor antagonists welcome a new era in endothelin biology
SA Douglas, EH Ohlstein, TD Meek
Trends in pharmacological sciences 15 (9), 313-316, 1994
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