| Drug–target residence time and its implications for lead optimization RA Copeland, DL Pompliano, TD Meek Nature reviews Drug discovery 5 (9), 730-739, 2006 | 1610 | 2006 |
| Identification of a novel aspartic protease (Asp 2) as β-secretase I Hussain, D Powell, DR Howlett, DG Tew, TD Meek, C Chapman, ... Molecular and Cellular Neuroscience 14 (6), 419-427, 1999 | 1595 | 1999 |
| Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor. C Debouck, JG Gorniak, JE Strickler, TD Meek, BW Metcalf, M Rosenberg Proceedings of the National Academy of Sciences 84 (24), 8903-8906, 1987 | 442 | 1987 |
| Human immunodeficiency virus-1 protease. 2. Use of pH rate studies and solvent kinetic isotope effects to elucidate details of chemical mechanism LJ Hyland, TA Tomaszek Jr, TD Meek Biochemistry 30 (34), 8454-8463, 1991 | 345 | 1991 |
| Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues TD Meek, DM Lambert, GB Dreyer, TJ Carr, TA Tomaszek, ML Moore, ... Nature 343 (6253), 90-92, 1990 | 322 | 1990 |
| Inhibition of human immunodeficiency virus 1 protease in vitro: rational design of substrate analogue inhibitors. GB Dreyer, BW Metcalf, TA Tomaszek Jr, TJ Carr, AC Chandler 3rd, ... Proceedings of the National Academy of Sciences 86 (24), 9752-9756, 1989 | 278 | 1989 |
| Human immunodeficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric aspartic protease. TD Meek, BD Dayton, BW Metcalf, GB Dreyer, JE Strickler, JG Gorniak, ... Proceedings of the National Academy of Sciences 86 (6), 1841-1845, 1989 | 267 | 1989 |
| ASP1 (BACE2) cleaves the amyloid precursor protein at the β-secretase site I Hussain, DJ Powell, DR Howlett, GA Chapman, L Gilmour, PR Murdock, ... Molecular and Cellular Neuroscience 16 (5), 609-619, 2000 | 244 | 2000 |
| 4-Aryl-1, 2, 3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo LS Kallander, Q Lu, W Chen, T Tomaszek, G Yang, D Tew, TD Meek, ... Journal of medicinal chemistry 48 (18), 5644-5647, 2005 | 236 | 2005 |
| Mechanistic enzymology in drug discovery: a fresh perspective GA Holdgate, TD Meek, RL Grimley Nature reviews Drug discovery 17 (2), 115-132, 2018 | 223 | 2018 |
| Peptide substrates and inhibitors of the HIV-1 protease ML Moore, WM Bryan, SA Fakhoury, VW Magaard, WF Huffman, ... Biochemical and biophysical research communications 159 (2), 420-425, 1989 | 215 | 1989 |
| Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica TD Meek, EP Garvey, DV Santi Biochemistry 24 (3), 678-686, 1985 | 192 | 1985 |
| Inhibitors of HIV-1 protease TD Meek Journal of enzyme inhibition 6 (1), 65-98, 1992 | 189 | 1992 |
| A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa CE Garrett, JA Coderre, TD Meek, EP Garvey, DM Claman, SM Beverley, ... Molecular and biochemical parasitology 11, 257-265, 1984 | 179 | 1984 |
| Human immunodeficiency virus-1 protease. 1. Initial velocity studies and kinetic characterization of reaction intermediates by oxygen-18 isotope exchange LJ Hyland, TA Tomaszek Jr, GD Roberts, SA Carr, VW Magaard, ... Biochemistry 30 (34), 8441-8453, 1991 | 175 | 1991 |
| Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays GB Dreyer, DM Lambert, TD Meek, TJ Carr, TA Tomaszek Jr, ... Biochemistry 31 (29), 6646-6659, 1992 | 169 | 1992 |
| Kinetic mechanism of Escherichia coli glutamine synthetase TD Meek, JJ Villafranca Biochemistry 19 (24), 5513-5519, 1980 | 169 | 1980 |
| Novel receptor antagonists welcome a new era in endothelin biology SA Douglas Trends Pharmacol Sci 15, 313-316, 1994 | 121 | 1994 |
| Use of protein unfolding studies to determine the conformational and dimeric stabilities of HIV-1 and SIV proteases SK Grant, IC Deckman, JS Culp, MD Minnich, IS Brooks, P Hensley, ... Biochemistry 31 (39), 9491-9501, 1992 | 121 | 1992 |
| Purification, characterization, and kinetic analysis of inosine 5′-monophosphate dehydrogenase of Tritrichomonas foetus R Verham, TD Meek, L Hedstrom, CC Wang Molecular and biochemical parasitology 24 (1), 1-12, 1987 | 113 | 1987 |
