Graeme Hewitt
Graeme Hewitt
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Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
G Hewitt, D Jurk, FDM Marques, C Correia-Melo, T Hardy, A Gackowska, ...
Nature communications 3 (1), 1-9, 2012
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
D Jurk, C Wilson, JF Passos, F Oakley, C Correia-Melo, L Greaves, ...
Nature communications 5, 4172, 2014
Mitochondria are required for pro‐ageing features of the senescent phenotype
C Correia‐Melo, FDM Marques, R Anderson, G Hewitt, R Hewitt, J Cole, ...
The EMBO journal, e201592862, 2016
Lysosome-mediated processing of chromatin in senescence
A Ivanov, J Pawlikowski, I Manoharan, J van Tuyn, DM Nelson, TS Rai, ...
J Cell Biol, jcb. 201212110, 2013
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers
CF Houlihan, N Vora, T Byrne, D Lewer, G Kelly, J Heaney, S Gandhi, ...
The Lancet 396 (10246), e6-e7, 2020
Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?
C Correia-Melo, G Hewitt, JF Passos
Longevity & healthspan 3 (1), 1, 2014
Mechanism and regulation of DNA-Protein crosslink repair by the DNA-dependent metalloprotease SPRTN
J Stingele, R Bellelli, F Alte, G Hewitt, G Sarek, SL Maslen, SE Tsutakawa, ...
Molecular Cell 64 (4), 688-703, 2016
DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease
J Birch, RK Anderson, C Correia-Melo, D Jurk, G Hewitt, FM Marques, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 309 …, 2015
SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair
G Hewitt, B Carroll, R Sarallah, C Correia-Melo, M Ogrodnik, G Nelson, ...
Autophagy 12 (10), 1917-1930, 2016
Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance
G Hewitt, VI Korolchuk
Trends in Cell Biology, 2016
Autophagy and ageing: implications for age-related neurodegenerative diseases
B Carroll, G Hewitt, VI Korolchuk
Essays in biochemistry 55, 119-131, 2013
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1
LC Lehmann, G Hewitt, S Aibara, A Leitner, E Marklund, SL Maslen, ...
Molecular Cell 68 (5), 847-859. e7, 2017
SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance
S Panier, M Maric, G Hewitt, E Mason-Osann, H Gali, A Dai, A Labadorf, ...
Molecular Cell, 2019
Scalable and robust SARS-CoV-2 testing in an academic center
J Aitken, K Ambrose, S Barrell, R Beale, G Bineva-Todd, D Biswas, ...
Nature biotechnology 38 (8), 927-931, 2020
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
G Hewitt, V Borel, S Segura-Bayona, T Takaki, P Ruis, R Bellelli, ...
Molecular Cell, 2020
Cell sorting of young and senescent cells
G Hewitt, T von Zglinicki, JF Passos
Biological Aging: Methods and Protocols, 31-47, 2013
Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch
LC Lehmann, L Bacic, G Hewitt, K Brackmann, A Sabantsev, G Gaullier, ...
Cell Reports 33 (12), 108529, 2020
RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions
P Kotsantis, S Segura-Bayona, P Margalef, P Marzec, P Ruis, G Hewitt, ...
Cell Reports 33 (12), 108546, 2020
mTORC1 activity is supported by spatial association with focal adhesions
Y Rabanal-Ruiz, A Byron, A Wirth, R Madsen, L Sedlackova, G Hewitt, ...
Journal of Cell Biology 220 (5), 2021
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors
K Fugger, I Bajrami, MS Dos Santos, SJ Young, S Kunzelmann, G Kelly, ...
Science 372 (6538), 156-165, 2021
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