| Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel C Bouzat, F Gumilar, G Spitzmaul, HL Wang, D Rayes, SB Hansen, ... Nature 430 (7002), 896-900, 2004 | 334 | 2004 |
| Congenital myasthenic syndrome caused by decreased agonist binding affinity due to a mutation in the acetylcholine receptor ε subunit K Ohno, HL Wang, M Milone, N Bren, JM Brengman, S Nakano, P Quiram, ... Neuron 17 (1), 157-170, 1996 | 267 | 1996 |
| Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1 I Ibañez-Tallon, JM Miwa, HL Wang, NC Adams, GW Crabtree, SM Sine, ... Neuron 33 (6), 893-903, 2002 | 251 | 2002 |
| New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome AG Engel, K Ohno, M Milone, HL Wang, S Nakano, C Bouzat, JN Pruitt, ... Human molecular genetics 5 (9), 1217-1227, 1996 | 245 | 1996 |
| Detection and trapping of intermediate states priming nicotinic receptor channel opening N Mukhtasimova, WY Lee, HL Wang, SM Sine Nature 459 (7245), 451-454, 2009 | 237 | 2009 |
| Congenital myasthenic syndromes due to heteroallelic nonsense/missense mutations in the acetylcholine receptor ε subunit gene: identification and functional characterization of … K Ohno, PA Quiram, M Milone, HL Wang, MC Harper, J Ned Pruitt, ... Human Molecular Genetics 6 (5), 753-766, 1997 | 167 | 1997 |
| Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine … M Milone, HL Wang, K Ohno, T Fukudome, JN Pruitt, N Bren, SM Sine, ... Journal of Neuroscience 17 (15), 5651-5665, 1997 | 166 | 1997 |
| Mutation in the M1 domain of the acetylcholine receptor α subunit decreases the rate of agonist dissociation HL Wang, A Auerbach, N Bren, K Ohno, AG Engel, SM Sine The Journal of general physiology 109 (6), 757-766, 1997 | 157 | 1997 |
| Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors X Cheng, H Wang, B Grant, SM Sine, JA McCammon PLoS computational biology 2 (9), e134, 2006 | 152 | 2006 |
| Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating HL Wang, M Milone, K Ohno, XM Shen, A Tsujino, AP Batocchi, P Tonali, ... Nature neuroscience 2 (3), 226-233, 1999 | 142 | 1999 |
| Mode switching kinetics produced by a naturally occurring mutation in the cytoplasmic loop of the human acetylcholine receptor ε subunit M Milone, HL Wang, K Ohno, R Prince, T Fukudome, XM Shen, ... Neuron 20 (3), 575-588, 1998 | 121 | 1998 |
| α-Conotoxins ImI and ImII target distinct regions of the human α7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes M Ellison, F Gao, HL Wang, SM Sine, JM McIntosh, BM Olivera Biochemistry 43 (51), 16019-16026, 2004 | 113 | 2004 |
| Asymmetric Structural Motions of the Homomeric α7 Nicotinic Receptor Ligand Binding Domain Revealed by Molecular Dynamics Simulation RH Henchman, HL Wang, SM Sine, P Taylor, JA McCammon Biophysical journal 85 (5), 3007-3018, 2003 | 95 | 2003 |
| Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain SM Sine, HL Wang, N Bren Journal of Biological Chemistry 277 (32), 29210-29223, 2002 | 90 | 2002 |
| Ligand-Induced Conformational Change in the α7 Nicotinic Receptor Ligand Binding Domain RH Henchman, HL Wang, SM Sine, P Taylor, JA McCammon Biophysical journal 88 (4), 2564-2576, 2005 | 89 | 2005 |
| Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome HL Wang, K Ohno, M Milone, JM Brengman, A Evoli, AP Batocchi, ... The Journal of general physiology 116 (3), 449-462, 2000 | 87 | 2000 |
| Nanosecond-Timescale Conformational Dynamics of the Human α7 Nicotinic Acetylcholine Receptor X Cheng, I Ivanov, H Wang, SM Sine, JA McCammon Biophysical journal 93 (8), 2622-2634, 2007 | 86 | 2007 |
| Impaired Ca2+-Dependent Activation of Large-Conductance Ca2+-Activated K+ Channels in the Coronary Artery Smooth Muscle Cells of Zucker Diabetic Fatty Rats T Lu, D Ye, T He, X Wang, H Wang, HC Lee Biophysical journal 95 (11), 5165-5177, 2008 | 78 | 2008 |
| Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating SM Sine, XM Shen, HL Wang, K Ohno, WY Lee, A Tsujino, J Brengmann, ... The Journal of general physiology 120 (4), 483-496, 2002 | 70 | 2002 |
| An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance SB Hansen, HL Wang, P Taylor, SM Sine Journal of Biological Chemistry 283 (52), 36066-36070, 2008 | 69 | 2008 |
