peter d. aplan
peter d. aplan
Senior Investigator national institutes of health
Verified email at
Cited by
Cited by
The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif
CG Begley, PD Aplan, SM Denning, BF Haynes, TA Waldmann, IR Kirsch
Proceedings of the National Academy of Sciences 86 (24), 10128-10132, 1989
Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion†…
CG Begley, PD Aplan, MP Davey, K Nakahara, K Tchorz, J Kurtzberg, ...
Proceedings of the National Academy of Sciences 86 (6), 2031-2035, 1989
Disruption of the human SCL locus by" illegitimate" V-(D)-J recombinase activity
PD Aplan, DP Lombardi, AM Ginsberg, J Cossman, VL Bertness, ...
Science 250 (4986), 1426-1429, 1990
SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-Tα chain expression
S Herblot, AM Steff, P Hugo, PD Aplan, T Hoang
Nature immunology 1 (2), 138-144, 2000
The SCL gene product: a positive regulator of erythroid differentiation.
PD Aplan, K Nakahara, SH Orkin, IR Kirsch
The EMBO Journal 11 (11), 4073-4081, 1992
NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights
SM Gough, CI Slape, PD Aplan
Blood 118 (24), 6247-6257, 2011
A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia
RJ Jaju, C Fidler, OA Haas, AJ Strickson, F Watkins, K Clark, NCP Cross, ...
Blood, The Journal of the American Society of Hematology 98 (4), 1264-1267, 2001
NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia
SZ Raza-Egilmez, SN Jani-Sait, M Grossi, MJ Higgins, TB Shows, ...
Cancer research 58 (19), 4269-4273, 1998
NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia
YW Lin, C Slape, Z Zhang, PD Aplan
Blood 106 (1), 287-295, 2005
Causes of oncogenic chromosomal translocation
PD Aplan
Trends in Genetics 22 (1), 46-55, 2006
Genome organization drives chromosome fragility
A Canela, Y Maman, S Jung, N Wong, E Callen, A Day, KR Kieffer-Kwon, ...
Cell 170 (3), 507-521. e18, 2017
DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis.
M Stanulla, J Wang, DS Chervinsky, S Thandla, PD Aplan
Molecular and cellular biology 17 (7), 4070-4079, 1997
Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors [see comments]
PD Aplan, DS Chervinsky, M Stanulla, WC Burhans
Loss of Smad3 in acute T-cell lymphoblastic leukemia
LA Wolfraim, TM Fernandez, M Mamura, WL Fuller, R Kumar, DE Cole, ...
New England Journal of Medicine 351 (6), 552-559, 2004
Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1
N Pineault, C Buske, M Feuring-Buske, C Abramovich, P Rosten, ...
Blood 101 (11), 4529-4538, 2003
Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia
PD Aplan, DP Lombardi, GH Reaman, HN Sather, GD Hammond, ...
An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T‐cell malignancies in transgenic mice
PD Aplan, CA Jones, DS Chervinsky, XF Zhao, MK Ellsworth, C Wu, ...
The EMBO journal 16 (9), 2408-2419, 1997
Cytogenetics and molecular genetics of acute lymphoblastic leukemia
K Mrůzek, DP Harper, PD Aplan
Hematology/Oncology Clinics 23 (5), 991-1010, 2009
DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier
MA Santos, RB Faryabi, AV Ergen, AM Day, A Malhowski, A Canela, ...
Nature 514 (7520), 107-111, 2014
The TLX1 oncogene drives aneuploidy in T cell transformation
K De Keersmaecker, PJ Real, G Della Gatta, T Palomero, ML Sulis, ...
Nature medicine 16 (11), 1321-1327, 2010
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