| The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants K Scheffzek, MR Ahmadian, W Kabsch, L Wiesmuller, A Lautwein, ... Science 277 (5324), 333-339, 1997 | 1965 | 1997 |
| CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes I Tiede, G Fritz, S Strand, D Poppe, R Dvorsky, D Strand, HA Lehr, S Wirtz, ... The Journal of clinical investigation 111 (8), 1133-1145, 2003 | 1021 | 2003 |
| GTPase-activating proteins: helping hands to complement an active site K Scheffzek, MR Ahmadian, A Wittinghofer Trends in biochemical sciences 23 (7), 257-262, 1998 | 569 | 1998 |
| Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. MR Ahmadian, P Stege, K Scheffzek, A Wittinghofer Nature structural biology 4 (9), 686-689, 1997 | 475 | 1997 |
| A restricted spectrum of NRAS mutations causes Noonan syndrome IC Cirstea, K Kutsche, R Dvorsky, L Gremer, C Carta, D Horn, AE Roberts, ... Nature genetics 42 (1), 27-29, 2010 | 351 | 2010 |
| Structural and mechanistic insights into the interaction between Rho and mammalian Dia R Rose, M Weyand, M Lammers, T Ishizaki, MR Ahmadian, A Wittinghofer Nature 435 (7041), 513-518, 2005 | 334 | 2005 |
| Formation of a transition-state analog of the Ras GTPase reaction by Ras· GDP, tetrafluoroaluminate, and GTPase-activating proteins R Mittal, MR Ahmadian, RS Goody, A Wittinghofer Science 273 (5271), 115-117, 1996 | 269 | 1996 |
| GTPase activating proteins: structural and functional insights 18 years after discovery K Scheffzek, MR Ahmadian Cellular and Molecular Life Sciences CMLS 62, 3014-3038, 2005 | 224 | 2005 |
| Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras K Scheffzek, A Lautwein, W Kabsch, M Reza Ahmadian, A Wittinghofer Nature 384 (6609), 591-596, 1996 | 213 | 1996 |
| Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules FPG van Horck, MR Ahmadian, LC Haeusler, WH Moolenaar, ... Journal of Biological Chemistry 276 (7), 4948-4956, 2001 | 211 | 2001 |
| Always look on the bright site of Rho: structural implications for a conserved intermolecular interface R Dvorsky, MR Ahmadian EMBO reports 5 (12), 1130-1136, 2004 | 205 | 2004 |
| Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase D Fiegen, LC Haeusler, L Blumenstein, U Herbrand, R Dvorsky, IR Vetter, ... Journal of Biological Chemistry 279 (6), 4743-4749, 2004 | 204 | 2004 |
| Structural analysis of the GAP-related domain from neurofibromin and its implications K Scheffzek, MR Ahmadian, L Wiesmüller, W Kabsch, P Stege, F Schmitz, ... The EMBO journal 17 (15), 4313-4327, 1998 | 204 | 1998 |
| The interaction of Ras with GTPase-activating proteins A Wittinghofer, K Scheffzek, MR Ahmadian FEBS letters 410 (1), 63-67, 1997 | 202 | 1997 |
| Rho-kinase: regulation,(dys) function, and inhibition E Amin, BN Dubey, SC Zhang, L Gremer, R Dvorsky, JM Moll, MS Taha, ... Biological chemistry 394 (11), 1399-1410, 2013 | 200 | 2013 |
| The balance of interleukin (IL)-6, IL-6· soluble IL-6 receptor (sIL-6R), and IL-6· sIL-6R· sgp130 complexes allows simultaneous classic and trans-signaling P Baran, S Hansen, GH Waetzig, M Akbarzadeh, L Lamertz, HJ Huber, ... Journal of Biological Chemistry 293 (18), 6762-6775, 2018 | 193 | 2018 |
| Guanosine triphosphatase stimulation of oncogenic Ras mutants MR Ahmadian, T Zor, D Vogt, W Kabsch, Z Selinger, A Wittinghofer, ... Proceedings of the National Academy of Sciences 96 (12), 7065-7070, 1999 | 187 | 1999 |
| Illuminating the functional and structural repertoire of human TBC/RABGAPs MAM Frasa, KT Koessmeier, MR Ahmadian, VMM Braga Nature reviews Molecular cell biology 13 (2), 67-73, 2012 | 185 | 2012 |
| Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network A Caye, M Strullu, F Guidez, B Cassinat, S Gazal, O Fenneteau, E Lainey, ... Nature genetics 47 (11), 1334-1340, 2015 | 180 | 2015 |
| Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy MR Ahmadian, U Hoffmann, RS Goody, A Wittinghofer Biochemistry 36 (15), 4535-4541, 1997 | 174 | 1997 |
