Jinwei Zhang
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The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters
DR Alessi, J Zhang, A Khanna, T Hochdörfer, Y Shang, KT Kahle
Science signaling 7 (334), re3-re3, 2014
The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl− co-transporters
P de los Heros, DR Alessi, R Gourlay, DG Campbell, M Deak, ...
Biochemical Journal 458 (3), 559-573, 2014
GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor
AD Reith, P Bamborough, K Jandu, D Andreotti, L Mensah, P Dossang, ...
Bioorganic & medicinal chemistry letters 22 (17), 5625-5629, 2012
Binding to serine 65‐phosphorylated ubiquitin primes Parkin for optimal PINK1‐dependent phosphorylation and activation
A Kazlauskaite, RJ Martínez‐Torres, S Wilkie, A Kumar, J Peltier, ...
EMBO reports 16 (8), 939-954, 2015
Brain penetrant LRRK2 inhibitor
HG Choi, J Zhang, X Deng, JM Hatcher, MP Patricelli, Z Zhao, DR Alessi, ...
ACS medicinal chemistry letters 3 (8), 658-662, 2012
Purification and characterization of a cold-adapted α-amylase produced by Nocardiopsis sp. 7326 isolated from Prydz Bay, Antarctic
JW Zhang, RY Zeng
Marine Biotechnology 10 (1), 75-82, 2008
Cloning, expression, and characterization of a cold-adapted lipase gene from an antarctic deep-sea psychorotrophic bacterium, Psychobacter sp. 7195
J Zhang, S Lin, R Zeng
Korean Society for Microbiology and Biotechnology, 2007
WNK Kinase Signaling in Ion Homeostasis and Human Disease
M Shekarabi, J Zhang, AR Khanna, DH Ellison, E Delpire, KT Kahle
Cell Metabolism 25 (2), 285-299, 2017
Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus
JK Karimy, J Zhang, DB Kurland, BC Theriault, D Duran, JA Stokum, ...
Nature medicine 23 (8), 997, 2017
Characterization of TAE684 as a potent LRRK2 kinase inhibitor
J Zhang, X Deng, HG Choi, DR Alessi, NS Gray
Bioorganic & medicinal chemistry letters 22 (5), 1864-1869, 2012
Molecular cloning and expression of a cold-adapted lipase gene from an Antarctic deep sea psychrotrophic bacterium Pseudomonas sp. 7323
J Zhang, R Zeng
Marine Biotechnology 10 (5), 612-621, 2008
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity
C Yao, WM Johnson, Y Gao, W Wang, J Zhang, M Deak, DR Alessi, X Zhu, ...
Human molecular genetics 22 (2), 328-344, 2013
WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons
P Friedel, KT Kahle, J Zhang, N Hertz, LI Pisella, E Buhler, F Schaller, ...
Science signaling 8 (383), ra65-ra65, 2015
Characterisation of the Cullin‐3 mutation that causes a severe form of familial hypertension and hyperkalaemia
FR Schumacher, K Siew, J Zhang, C Johnson, N Wood, SE Cleary, ...
EMBO molecular medicine 7 (10), 1285-1306, 2015
Enhanced electricity production by use of reconstituted artificial consortia of estuarine bacteria grown as biofilms
J Zhang, E Zhang, K Scott, JG Burgess
Environmental science & technology 46 (5), 2984-2992, 2012
Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones
X Deng, JM Elkins, J Zhang, Q Yang, T Erazo, N Gomez, HG Choi, ...
European journal of medicinal chemistry 70, 758-767, 2013
Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor
JM Hatcher, J Zhang, HG Choi, G Ito, DR Alessi, NS Gray
ACS medicinal chemistry letters 6 (5), 584-589, 2015
Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter
KT Kahle, B Flores, D Bharucha-Goebel, J Zhang, S Donkervoort, ...
Science signaling 9 (439), ra77-ra77, 2016
GABA A receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase
M Heubl, J Zhang, JC Pressey, S Al Awabdh, M Renner, F Gomez-Castro, ...
Nature communications 8 (1), 1-17, 2017
Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition
KT Kahle, JF Schmouth, V Lavastre, A Latremoliere, J Zhang, N Andrews, ...
Science signaling 9 (421), ra32-ra32, 2016
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