|Glypican-1 identifies cancer exosomes and detects early pancreatic cancer|
SA Melo, LB Luecke, C Kahlert, AF Fernandez, ST Gammon, J Kaye, ...
Nature 523 (7559), 177-182, 2015
|Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis|
SA Melo, H Sugimoto, JT O’Connell, N Kato, A Villanueva, A Vidal, L Qiu, ...
Cancer cell 26 (5), 707-721, 2014
|Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer|
S Kamerkar, VS LeBleu, H Sugimoto, S Yang, CF Ruivo, SA Melo, JJ Lee, ...
Nature 546 (7659), 498-503, 2017
|Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer|
C Kahlert, SA Melo, A Protopopov, J Tang, S Seth, M Koch, J Zhang, ...
Journal of Biological Chemistry 289 (7), 3869-3875, 2014
|eRNAs are required for p53-dependent enhancer activity and gene transcription|
CA Melo, J Drost, PJ Wijchers, H van de Werken, E de Wit, JAFO Vrielink, ...
Molecular cell 49 (3), 524-535, 2013
|Dysregulation of microRNAs in cancer: playing with fire|
SA Melo, M Esteller
FEBS letters 585 (13), 2087-2099, 2011
|A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells|
SA Melo, C Moutinho, S Ropero, GA Calin, S Rossi, R Spizzo, ...
Cancer cell 18 (4), 303-315, 2010
|TGF-β1–containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis|
FT Borges, SA Melo, BC Özdemir, N Kato, I Revuelta, CA Miller, ...
Journal of the American Society of Nephrology 24 (3), 385-392, 2013
|The biology of cancer exosomes: insights and new perspectives|
CF Ruivo, B Adem, M Silva, SA Melo
Cancer research 77 (23), 6480-6488, 2017
|The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer|
AF Fernandez, C Rosales, P Lopez-Nieva, O Grańa, E Ballestar, ...
Genome research 19 (3), 438-451, 2009
|Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing|
S Melo, A Villanueva, C Moutinho, V Davalos, R Spizzo, C Ivan, S Rossi, ...
Proceedings of the National Academy of Sciences 108 (11), 4394-4399, 2011
|CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer|
A Lujambio, A Portela, J Liz, SA Melo, S Rossi, R Spizzo, CM Croce, ...
Oncogene 29 (48), 6390-6401, 2010
|The fusion of two worlds: Non-coding RNAs and extracellular vesicles-diagnostic and therapeutic implications|
Y Sato-Kuwabara, SA Melo, FA Soares, GA Calin
International journal of oncology 46 (1), 17-27, 2015
|Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA|
N Léveillé, CA Melo, K Rooijers, A Díaz-Lagares, SA Melo, G Korkmaz, ...
Nature communications 6 (1), 1-12, 2015
|Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer|
S Yang, SPY Che, P Kurywchak, JL Tavormina, LB Gansmo, ...
Cancer biology & therapy 18 (3), 158-165, 2017
|Exosomes and immune response in cancer: friends or foes?|
FM Barros, F Carneiro, JC Machado, SA Melo
Frontiers in immunology 9, 730, 2018
|Molecular pathways: microRNAs as cancer therapeutics|
SA Melo, R Kalluri
Clinical cancer research 18 (16), 4234-4239, 2012
|Blocking tumor-educated MSC paracrine activity halts osteosarcoma progression|
SR Baglio, T Lagerweij, M Pérez-Lanzón, XD Ho, N Léveillé, SA Melo, ...
Clinical Cancer Research 23 (14), 3721-3733, 2017
|Exosomes in cancer: Use them or target them?|
N Bastos, CF Ruivo, S da Silva, SA Melo
Seminars in cell & developmental biology 78, 13-21, 2018
|N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration|
I Rigoutsos, SK Lee, SY Nam, S Anfossi, B Pasculli, M Pichler, Y Jing, ...
Genome biology 18 (1), 1-21, 2017