| Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway RJ Orton, OE Sturm, V Vyshemirsky, M Calder, DR Gilbert, W Kolch Biochemical Journal 392 (2), 249-261, 2005 | 393 | 2005 |
| Cell fate decisions are specified by the dynamic ERK interactome A Von Kriegsheim, D Baiocchi, M Birtwistle, D Sumpton, W Bienvenut, ... Nature cell biology 11 (12), 1458, 2009 | 250 | 2009 |
| Consensus statement: virus taxonomy in the age of metagenomics P Simmonds, MJ Adams, M Benkő, M Breitbart, JR Brister, EB Carstens, ... Nature Reviews Microbiology 15 (3), 161, 2017 | 222 | 2017 |
| The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier OE Sturm, R Orton, J Grindlay, M Birtwistle, V Vyshemirsky, D Gilbert, ... Sci. Signal. 3 (153), ra90-ra90, 2010 | 204 | 2010 |
| Late Ebola virus relapse causing meningoencephalitis: a case report M Jacobs, A Rodger, DJ Bell, S Bhagani, I Cropley, A Filipe, RJ Gifford, ... The Lancet 388 (10043), 498-503, 2016 | 153 | 2016 |
| Whole genome sequencing reveals local transmission patterns of Mycobacterium bovis in sympatric cattle and badger populations R Biek, A O'Hare, D Wright, T Mallon, C McCormick, RJ Orton, ... PLoS pathogens 8 (11), e1003008, 2012 | 121 | 2012 |
| Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV) EJ Lefkowitz, DM Dempsey, RC Hendrickson, RJ Orton, SG Siddell, ... Nucleic Acids Research 46 (D1), D708-D717, 2017 | 107 | 2017 |
| Computational methodologies for modelling, analysis and simulation of signalling networks D Gilbert, H Fuß, X Gu, R Orton, S Robinson, V Vyshemirsky, MJ Kurth, ... Briefings in Bioinformatics 7 (4), 339-353, 2006 | 104 | 2006 |
| Analysis of signalling pathways using continuous time Markov chains M Calder, V Vyshemirsky, D Gilbert, R Orton Transactions on Computational Systems Biology VI, 44-67, 2006 | 96 | 2006 |
| A structured approach for the engineering of biochemical network models, illustrated for signalling pathways R Breitling, D Gilbert, M Heiner, R Orton Briefings in bioinformatics 9 (5), 404-421, 2008 | 90 | 2008 |
| Analysis of signalling pathways using the PRISM model checker M Calder, V Vyshemirsky, D Gilbert, R Orton University of Edinburgh, 2005 | 76 | 2005 |
| Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway RJ Orton, ME Adriaens, A Gormand, OE Sturm, W Kolch, DR Gilbert BMC Systems Biology 3 (1), 100, 2009 | 61 | 2009 |
| Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses AE Shaw, J Hughes, Q Gu, A Behdenna, JB Singer, T Dennis, RJ Orton, ... PLoS biology 15 (12), e2004086, 2017 | 47 | 2017 |
| Risk factors for bovine tuberculosis at the national level in Great Britain PR Bessell, R Orton, PCL White, MR Hutchings, RR Kao BMC Veterinary Research 8 (1), 51, 2012 | 44 | 2012 |
| 50 years of the International Committee on Taxonomy of Viruses: progress and prospects MJ Adams, EJ Lefkowitz, AMQ King, B Harrach, RL Harrison, NJ Knowles, ... Archives of virology 162 (5), 1441-1446, 2017 | 38 | 2017 |
| Estimating epidemiological parameters for bovine tuberculosis in British cattle using a Bayesian partial-likelihood approach A O'Hare, RJ Orton, PR Bessell, RR Kao Proceedings of the Royal Society B: Biological Sciences 281 (1783), 20140248, 2014 | 37 | 2014 |
| Use of bacterial whole-genome sequencing to investigate local persistence and spread in bovine tuberculosis H Trewby, D Wright, EL Breadon, SJ Lycett, TR Mallon, C McCormick, ... Epidemics 14, 26-35, 2016 | 28 | 2016 |
| Observing micro-evolutionary processes of viral populations at multiple scales RJ Orton, CF Wright, MJ Morelli, N Juleff, G Thébaud, NJ Knowles, ... Philosophical Transactions of the Royal Society B: Biological Sciences 368 …, 2013 | 28 | 2013 |
| Distinguishing low frequency mutations from RT-PCR and sequence errors in viral deep sequencing data RJ Orton, CF Wright, MJ Morelli, DJ King, DJ Paton, DP King, DT Haydon BMC genomics 16 (1), 229, 2015 | 27 | 2015 |
| Next-generation sequencing in veterinary medicine: how can the massive amount of information arising from high-throughput technologies improve diagnosis, control, and … S Van Borm, S Belák, G Freimanis, A Fusaro, F Granberg, D Höper, ... Veterinary infection biology: molecular diagnostics and high-throughput …, 2015 | 23 | 2015 |
David GilbertProfessor of Computer Science, Brunel UniversityVerified email at brunel.ac.uk