Richard Orton
Richard Orton
CVR Bioinformatics, MRC-University of Glasgow Centre for Virus Research
Verified email at glasgow.ac.uk - Homepage
TitleCited byYear
Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway
RJ Orton, OE Sturm, V Vyshemirsky, M Calder, DR Gilbert, W Kolch
Biochemical Journal 392 (2), 249-261, 2005
3932005
Cell fate decisions are specified by the dynamic ERK interactome
A Von Kriegsheim, D Baiocchi, M Birtwistle, D Sumpton, W Bienvenut, ...
Nature cell biology 11 (12), 1458, 2009
2502009
Consensus statement: virus taxonomy in the age of metagenomics
P Simmonds, MJ Adams, M Benkő, M Breitbart, JR Brister, EB Carstens, ...
Nature Reviews Microbiology 15 (3), 161, 2017
2222017
The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier
OE Sturm, R Orton, J Grindlay, M Birtwistle, V Vyshemirsky, D Gilbert, ...
Sci. Signal. 3 (153), ra90-ra90, 2010
2042010
Late Ebola virus relapse causing meningoencephalitis: a case report
M Jacobs, A Rodger, DJ Bell, S Bhagani, I Cropley, A Filipe, RJ Gifford, ...
The Lancet 388 (10043), 498-503, 2016
1532016
Whole genome sequencing reveals local transmission patterns of Mycobacterium bovis in sympatric cattle and badger populations
R Biek, A O'Hare, D Wright, T Mallon, C McCormick, RJ Orton, ...
PLoS pathogens 8 (11), e1003008, 2012
1212012
Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV)
EJ Lefkowitz, DM Dempsey, RC Hendrickson, RJ Orton, SG Siddell, ...
Nucleic Acids Research 46 (D1), D708-D717, 2017
1072017
Computational methodologies for modelling, analysis and simulation of signalling networks
D Gilbert, H Fuß, X Gu, R Orton, S Robinson, V Vyshemirsky, MJ Kurth, ...
Briefings in Bioinformatics 7 (4), 339-353, 2006
1042006
Analysis of signalling pathways using continuous time Markov chains
M Calder, V Vyshemirsky, D Gilbert, R Orton
Transactions on Computational Systems Biology VI, 44-67, 2006
962006
A structured approach for the engineering of biochemical network models, illustrated for signalling pathways
R Breitling, D Gilbert, M Heiner, R Orton
Briefings in bioinformatics 9 (5), 404-421, 2008
902008
Analysis of signalling pathways using the PRISM model checker
M Calder, V Vyshemirsky, D Gilbert, R Orton
University of Edinburgh, 2005
762005
Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway
RJ Orton, ME Adriaens, A Gormand, OE Sturm, W Kolch, DR Gilbert
BMC Systems Biology 3 (1), 100, 2009
612009
Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses
AE Shaw, J Hughes, Q Gu, A Behdenna, JB Singer, T Dennis, RJ Orton, ...
PLoS biology 15 (12), e2004086, 2017
472017
Risk factors for bovine tuberculosis at the national level in Great Britain
PR Bessell, R Orton, PCL White, MR Hutchings, RR Kao
BMC Veterinary Research 8 (1), 51, 2012
442012
50 years of the International Committee on Taxonomy of Viruses: progress and prospects
MJ Adams, EJ Lefkowitz, AMQ King, B Harrach, RL Harrison, NJ Knowles, ...
Archives of virology 162 (5), 1441-1446, 2017
382017
Estimating epidemiological parameters for bovine tuberculosis in British cattle using a Bayesian partial-likelihood approach
A O'Hare, RJ Orton, PR Bessell, RR Kao
Proceedings of the Royal Society B: Biological Sciences 281 (1783), 20140248, 2014
372014
Use of bacterial whole-genome sequencing to investigate local persistence and spread in bovine tuberculosis
H Trewby, D Wright, EL Breadon, SJ Lycett, TR Mallon, C McCormick, ...
Epidemics 14, 26-35, 2016
282016
Observing micro-evolutionary processes of viral populations at multiple scales
RJ Orton, CF Wright, MJ Morelli, N Juleff, G Thébaud, NJ Knowles, ...
Philosophical Transactions of the Royal Society B: Biological Sciences 368 …, 2013
282013
Distinguishing low frequency mutations from RT-PCR and sequence errors in viral deep sequencing data
RJ Orton, CF Wright, MJ Morelli, DJ King, DJ Paton, DP King, DT Haydon
BMC genomics 16 (1), 229, 2015
272015
Next-generation sequencing in veterinary medicine: how can the massive amount of information arising from high-throughput technologies improve diagnosis, control, and …
S Van Borm, S Belák, G Freimanis, A Fusaro, F Granberg, D Höper, ...
Veterinary infection biology: molecular diagnostics and high-throughput …, 2015
232015
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