| FLICE, a novel FADD-homologous ICE/CED-3–like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex M Muzio, AM Chinnaiyan, FC Kischkel, K O'Rourke, A Shevchenko, J Ni, ... Cell 85 (6), 817-827, 1996 | 3978 | 1996 |
| Cryopyrin activates the inflammasome in response to toxins and ATP S Mariathasan, DS Weiss, K Newton, J McBride, K O'Rourke, ... Nature 440 (7081), 228-232, 2006 | 3568 | 2006 |
| FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis AM Chinnaiyan, K O'Rourke, M Tewari, VM Dixit Cell 81 (4), 505-512, 1995 | 3467 | 1995 |
| Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling N Kayagaki, IB Stowe, BL Lee, K O’Rourke, K Anderson, S Warming, ... Nature 526 (7575), 666-671, 2015 | 3334 | 2015 |
| Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase M Tewari, LT Quan, K O'Rourke, S Desnoyers, Z Zeng, DR Beidler, ... Cell 81 (5), 801-809, 1995 | 3043 | 1995 |
| The receptor for the cytotoxic ligand TRAIL G Pan, K O'Rourke, AM Chinnaiyan, R Gentz, R Ebner, J Ni, VM Dixit Science 276 (5309), 111-113, 1997 | 2449 | 1997 |
| De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling IE Wertz, KM O'rourke, H Zhou, M Eby, L Aravind, S Seshagiri, P Wu, ... Nature 430 (7000), 694-699, 2004 | 2214 | 2004 |
| Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma AG Uren, K O'Rourke, LA Aravind, MT Pisabarro, S Seshagiri, EV Koonin, ... Molecular cell 6 (4), 961-967, 2000 | 1341 | 2000 |
| FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis (∗) AM Chinnaiyan, CG Tepper, MF Seldin, K O'Rourke, FC Kischkel, ... Journal of Biological Chemistry 271 (9), 4961-4965, 1996 | 1065 | 1996 |
| Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death AM Chinnaiyan, K O'Rourke, BR Lane, VM Dixit Science 275 (5303), 1122-1126, 1997 | 947 | 1997 |
| The ubiquitin ligase COP1 is a critical negative regulator of p53 D Dornan, I Wertz, H Shimizu, D Arnott, GD Frantz, P Dowd, K O'Rourke, ... Nature 429 (6987), 86-92, 2004 | 918 | 2004 |
| Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 IE Wertz, S Kusam, C Lam, T Okamoto, W Sandoval, DJ Anderson, ... Nature 471 (7336), 110-114, 2011 | 899 | 2011 |
| Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95 AM Chinnaiyan, K O'Rourke, GL Yu, RH Lyons, M Garg, DR Duan, L Xing, ... Science 274 (5289), 990-992, 1996 | 885 | 1996 |
| Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex G Pan, K O'Rourke, VM Dixit Journal of Biological Chemistry 273 (10), 5841-5845, 1998 | 810 | 1998 |
| Molecular Ordering of the Cell Death Pathway: Bcl-2 AND Bcl-xL Function upstream of the CED-3-like apoptotic proteases (∗) AM Chinnaiyan, K Orth, K O'Rourke, H Duan, GG Poirier, VM Dixit Journal of Biological Chemistry 271 (9), 4573-4576, 1996 | 768 | 1996 |
| Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival M Schwickart, XD Huang, JR Lill, J Liu, R Ferrando, DM French, ... Nature 463 (7277), 103-107, 2010 | 736 | 2010 |
| Bcl10 activates the NF-κB pathway through ubiquitination of NEMO H Zhou, I Wertz, K O'Rourke, M Ultsch, S Seshagiri, M Eby, W Xiao, ... Nature 427 (6970), 167-171, 2004 | 684 | 2004 |
| Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis JW Jones, N Kayagaki, P Broz, T Henry, K Newton, K O'Rourke, S Chan, ... Proceedings of the National Academy of Sciences 107 (21), 9771-9776, 2010 | 590 | 2010 |
| A deubiquitinase that regulates type I interferon production N Kayagaki, Q Phung, S Chan, R Chaudhari, C Quan, KM O'Rourke, ... Science 318 (5856), 1628-1632, 2007 | 536 | 2007 |
| NINJ1 mediates plasma membrane rupture during lytic cell death N Kayagaki, OS Kornfeld, BL Lee, IB Stowe, K O’Rourke, Q Li, ... Nature 591 (7848), 131-136, 2021 | 524 | 2021 |
Vishva Dixitvice-president, GenentechVerified email at gene.com
