Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating … P Godoy, NJ Hewitt, U Albrecht, ME Andersen, N Ansari, S Bhattacharya, ... Archives of toxicology 87 (8), 1315-1530, 2013 | 1131 | 2013 |
A single-cell-based model of tumor growth in vitro: monolayers and spheroids D Drasdo, S Höhme Physical biology 2 (3), 133, 2005 | 443 | 2005 |
Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration S Hoehme, M Brulport, A Bauer, E Bedawy, W Schormann, M Hermes, ... Proceedings of the National Academy of Sciences 107 (23), 10371-10376, 2010 | 343 | 2010 |
Modeling the effect of deregulated proliferation and apoptosis on the growth dynamics of epithelial cell populations in vitro J Galle, M Loeffler, D Drasdo Biophysical journal 88 (1), 62-75, 2005 | 315 | 2005 |
Individual-based and continuum models of growing cell populations: a comparison H Byrne, D Drasdo Journal of mathematical biology 58 (4), 657-687, 2009 | 308 | 2009 |
Modeling the influence of the E-cadherin-β-catenin pathway in cancer cell invasion: a multiscale approach I Ramis-Conde, D Drasdo, ARA Anderson, MAJ Chaplain Biophysical journal 95 (1), 155-165, 2008 | 265 | 2008 |
Adverse outcome pathways: opportunities, limitations and open questions M Leist, A Ghallab, R Graepel, R Marchan, R Hassan, SH Bennekou, ... Archives of toxicology 91 (11), 3477-3505, 2017 | 247 | 2017 |
Monte Carlo approach to tissue-cell populations D Drasdo, R Kree, JS McCaskill Physical review E 52 (6), 6635, 1995 | 209 | 1995 |
On the role of physics in the growth and pattern formation of multi-cellular systems: what can we learn from individual-cell based models? D Drasdo, S Hoehme, M Block Journal of Statistical Physics 128 (1), 287-345, 2007 | 201 | 2007 |
Simulating tissue mechanics with agent-based models: concepts, perspectives and some novel results P Van Liedekerke, MM Palm, N Jagiella, D Drasdo Computational particle mechanics 2 (4), 401-444, 2015 | 197 | 2015 |
Multi-scale modelling of cancer cell intravasation: the role of cadherins in metastasis I Ramis-Conde, MAJ Chaplain, ARA Anderson, D Drasdo Physical biology 6 (1), 016008, 2009 | 190 | 2009 |
Individual-based approaches to birth and death in avascu1ar tumors D Drasdo, S Höhme Mathematical and Computer Modelling 37 (11), 1163-1175, 2003 | 160 | 2003 |
A cell-based simulation software for multi-cellular systems S Hoehme, D Drasdo Bioinformatics 26 (20), 2641-2642, 2010 | 154 | 2010 |
Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue … S Hammad, S Hoehme, A Friebel, I Von Recklinghausen, A Othman, ... Archives of toxicology 88 (5), 1161-1183, 2014 | 122 | 2014 |
Individual-based models to growth and folding in one-layered tissues: intestinal crypts and early development D Drasdo, M Loeffler Nonlinear Analysis: Theory, Methods & Applications 47 (1), 245-256, 2001 | 112 | 2001 |
Buckling instabilities of one-layered growing tissues D Drasdo Physical review letters 84 (18), 4244, 2000 | 112 | 2000 |
The virtual liver: a multidisciplinary, multilevel challenge for systems biology HG Holzhütter, D Drasdo, T Preusser, J Lippert, AM Henney Wiley Interdisciplinary Reviews: Systems Biology and Medicine 4 (3), 221-235, 2012 | 110 | 2012 |
Impact of oxygen environment on mesenchymal stem cell expansion and chondrogenic differentiation A Krinner, M Zscharnack, A Bader, D Drasdo, J Galle Cell proliferation 42 (4), 471-484, 2009 | 110 | 2009 |
Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases A Ghallab, G Cellière, SG Henkel, D Driesch, S Hoehme, U Hofmann, ... Journal of hepatology 64 (4), 860-871, 2016 | 108 | 2016 |
Modeling the interplay of generic and genetic mechanisms in cleavage, blastulation, and gastrulation D Drasdo, G Forgacs Developmental dynamics: an official publication of the American Association …, 2000 | 105 | 2000 |