|Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence|
G Hewitt, D Jurk, FDM Marques, C Correia-Melo, T Hardy, A Gackowska, ...
Nature communications 3 (1), 1-9, 2012
|Chronic inflammation induces telomere dysfunction and accelerates ageing in mice|
D Jurk, C Wilson, JF Passos, F Oakley, C Correia-Melo, L Greaves, ...
Nature communications 5 (1), 1-14, 2014
|MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis|
J Mann, DCK Chu, A Maxwell, F Oakley, NL Zhu, H Tsukamoto, DA Mann
Gastroenterology 138 (2), 705-714. e4, 2010
|Multigenerational epigenetic adaptation of the hepatic wound-healing response|
M Zeybel, T Hardy, YK Wong, JC Mathers, CR Fox, A Gackowska, ...
Nature medicine 18 (9), 1369-1377, 2012
|Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis|
J Mann, F Oakley, F Akiboye, A Elsharkawy, AW Thorne, DA Mann
Cell Death & Differentiation 14 (2), 275-285, 2007
|Stimulating healthy tissue regeneration by targeting the 5-HT 2B receptor in chronic liver disease|
MR Ebrahimkhani, F Oakley, LB Murphy, J Mann, A Moles, MJ Perugorria, ...
Nature medicine 17 (12), 1668-1673, 2011
|A failure of transforming growth factor-β1 negative regulation maintains sustained NF-κB activation in gut inflammation|
G Monteleone, J Mann, I Monteleone, P Vavassori, R Bremner, M Fantini, ...
Journal of Biological Chemistry 279 (6), 3925-3932, 2004
|Pilot testing of Pichia guilliermondii: a biocontrol agent of postharvest diseases of citrus fruit|
S Droby, R Hofstein, CL Wilson, M Wisniewski, B Fridlender, L Cohen, ...
Biological Control 3 (1), 47-52, 1993
|The NF-κB p50: p50: HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes|
AM Elsharkawy, F Oakley, F Lin, G Packham, DA Mann, J Mann
Journal of hepatology 53 (3), 519-527, 2010
|Low-strength T-cell activation promotes Th17 responses|
HA Purvis, JN Stoop, J Mann, S Woods, AE Kozijn, S Hambleton, ...
Blood, The Journal of the American Society of Hematology 116 (23), 4829-4837, 2010
|Nuclear factor-κB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury|
F Oakley, J Mann, S Nailard, DE Smart, N Mungalsingh, C Constandinou, ...
The American journal of pathology 166 (3), 695-708, 2005
|Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis|
SFW Kendrick, G O'Boyle, J Mann, M Zeybel, J Palmer, DEJ Jones, ...
Hepatology 51 (6), 1988-1997, 2010
|Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence|
R Anderson, A Lagnado, D Maggiorani, A Walaszczyk, E Dookun, ...
The EMBO journal 38 (5), e100492, 2019
|Transcriptional regulation of hepatic stellate cells|
J Mann, DA Mann
Advanced drug delivery reviews 61 (7-8), 497-512, 2009
|IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts|
MI Suwara, NJ Green, LA Borthwick, J Mann, KD Mayer-Barber, L Barron, ...
Mucosal immunology 7 (3), 684-693, 2014
|JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells|
DE Smart, KJ Vincent, MJP Arthur, O Eickelberg, M Castellazzi, J Mann, ...
Journal of Biological Chemistry 276 (26), 24414-24421, 2001
|Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease|
T Hardy, M Zeybel, CP Day, C Dipper, S Masson, S McPherson, ...
Gut 66 (7), 1321-1328, 2017
|A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse|
A Moles, L Murphy, CL Wilson, JB Chakraborty, C Fox, EJ Park, J Mann, ...
Journal of hepatology 60 (4), 782-791, 2014
|Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator‐activated receptor γ in hepatic stellate cells for their antifibrotic effect|
MD Yang, YM Chiang, R Higashiyama, K Asahina, DA Mann, J Mann, ...
Hepatology 55 (4), 1271-1281, 2012
|Basal expression of IκBα is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1|
F Oakley, J Mann, RG Ruddell, J Pickford, G Weinmaster, DA Mann
Journal of Biological Chemistry 278 (27), 24359-24370, 2003