| Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains DA Hay, O Fedorov, S Martin, DC Singleton, C Tallant, C Wells, S Picaud, ... Journal of the American Chemical Society 136 (26), 9308-9319, 2014 | 321 | 2014 |
| Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia T Rzymski, M Milani, DC Singleton, AL Harris Cell cycle 8 (23), 3838-3847, 2009 | 221 | 2009 |
| Therapeutic targeting of the hypoxic tumour microenvironment DC Singleton, A Macann, WR Wilson Nature reviews Clinical oncology 18 (12), 751-772, 2021 | 207 | 2021 |
| LP99: discovery and synthesis of the first selective BRD7/9 bromodomain inhibitor PGK Clark, LCC Vieira, C Tallant, O Fedorov, DC Singleton, CM Rogers, ... Angewandte Chemie 127 (21), 6315-6319, 2015 | 199 | 2015 |
| Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival LRG Pike, DC Singleton, F Buffa, O Abramczyk, K Phadwal, JL Li, ... Biochemical Journal 449 (2), 389-400, 2013 | 165 | 2013 |
| Targeting the ATF4 pathway in cancer therapy DC Singleton, AL Harris Expert opinion on therapeutic targets 16 (12), 1189-1202, 2012 | 148 | 2012 |
| Bystander or no bystander for gene directed enzyme prodrug therapy GU Dachs, MA Hunt, S Syddall, DC Singleton, AV Patterson Molecules 14 (11), 4517-4545, 2009 | 136 | 2009 |
| Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium EO Pettersen, P Ebbesen, RG Gieling, KJ Williams, L Dubois, P Lambin, ... Journal of enzyme inhibition and medicinal chemistry 30 (5), 689-721, 2015 | 125 | 2015 |
| Disrupting hypoxia-induced bicarbonate transport acidifies tumor cells and suppresses tumor growth A McIntyre, A Hulikova, I Ledaki, C Snell, D Singleton, G Steers, P Seden, ... Cancer research 76 (13), 3744-3755, 2016 | 93 | 2016 |
| Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts K Kumar, S Wigfield, HE Gee, CM Devlin, D Singleton, JL Li, F Buffa, ... Journal of molecular medicine 91, 749-758, 2013 | 89 | 2013 |
| The nitroreductase prodrug SN 28343 enhances the potency of systemically administered armed oncolytic adenovirus ONYX-411NTR DC Singleton, D Li, SY Bai, SP Syddall, JB Smaill, Y Shen, WA Denny, ... Cancer gene therapy 14 (12), 953-967, 2007 | 59 | 2007 |
| Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis DC Singleton, P Rouhi, CE Zois, S Haider, JL Li, BM Kessler, Y Cao, ... Oncogene 34 (36), 4713-4722, 2015 | 55 | 2015 |
| Method for the fluorescent detection of nitroreductase activity using nitro-substituted aromatic compounds JB Smaill, AV Patterson, DC Singleton US Patent App. 12/440,267, 2010 | 49 | 2010 |
| Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer DC Singleton, AL Dechaume, PM Murray, WP Katt, BC Baguley, ... BMC cancer 20, 1-13, 2020 | 28 | 2020 |
| Patient-derived xenograft and organoid models for precision medicine targeting of the tumour microenvironment in head and neck cancer TW Lee, A Lai, JK Harms, DC Singleton, BD Dickson, AMJ Macann, ... Cancers 12 (12), 3743, 2020 | 25 | 2020 |
| Derivation of breast cancer cell lines under physiological (5%) oxygen concentrations EY Leung, ME Askarian-Amiri, DC Singleton, C Ferraro-Peyret, ... Frontiers in oncology 8, 425, 2018 | 17 | 2018 |
| N-methyl-D-aspartate receptor hypofunction in Meg-01 cells reveals a role for intracellular calcium homeostasis in balancing megakaryocytic-erythroid differentiation JI Hearn, TN Green, M Chopra, YNS Nursalim, L Ladvanszky, N Knowlton, ... Thrombosis and Haemostasis 120 (04), 671-686, 2020 | 12 | 2020 |
| Hypoxia‐Activated Prodrugs of PERK Inhibitors LP Liew, DC Singleton, WW Wong, GJ Cheng, SMF Jamieson, MP Hay Chemistry–An Asian Journal 14 (8), 1238-1248, 2019 | 12 | 2019 |
| In vitro breast cancer models for studying mechanisms of resistance to endocrine therapy GJ Cheng, EY Leung, DC Singleton Exploration of Targeted Anti-tumor Therapy 3 (3), 297, 2022 | 6 | 2022 |
| ATF4, hypoxia and treatment resistance in cancer DC Singleton, AL Harris The Unfolded Protein Response in Cancer, 75-108, 2019 | 4 | 2019 |
Adrian L HarrisProfessor of Medical Oncology, Oxford UniversityVerified email at oncology.ox.ac.uk
