| Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but … M Fujimura, F Usuki, M Sawada, A Takashima Neurotoxicology 30 (6), 1000-1007, 2009 | 121 | 2009 |
| In vivo protection of a water-soluble derivative of vitamin E, Trolox, against methylmercury-intoxication in the rat F Usuki, A Yasutake, F Umehara, H Tokunaga, M Matsumoto, K Eto, ... Neuroscience letters 304 (3), 199-203, 2001 | 108 | 2001 |
| Inhibition of nonsense‐mediated mRNA decay rescues the phenotype in Ullrich's disease F Usuki, A Yamashita, I Higuchi, T Ohnishi, T Shiraishi, M Osame, S Ohno Annals of Neurology: Official Journal of the American Neurological …, 2004 | 104 | 2004 |
| Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts F Usuki, A Yamashita, I Kashima, I Higuchi, M Osame, S Ohno Molecular Therapy 14 (3), 351-360, 2006 | 103 | 2006 |
| Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure F Usuki, A Yamashita, M Fujimura Journal of biological chemistry 286 (8), 6641-6649, 2011 | 87 | 2011 |
| Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure M Fujimura, F Usuki, M Kawamura, S Izumo Toxicology and applied pharmacology 250 (1), 1-9, 2011 | 78 | 2011 |
| Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons M Fujimura, F Usuki, M Sawada, W Rostene, D Godefroy, A Takashima Neurotoxicology 30 (1), 16-22, 2009 | 68 | 2009 |
| Methylmercury activates ASK1/JNK signaling pathways, leading to apoptosis due to both mitochondria-and endoplasmic reticulum (ER)-generated processes in myogenic cell lines F Usuki, E Fujita, N Sasagawa Neurotoxicology 29 (1), 22-30, 2008 | 64 | 2008 |
| Expanded CTG repeats in myotonin protein kinase increase susceptibility to oxidative stress F Usuki, S Ishiura Neuroreport 9 (10), 2291-2296, 1998 | 58 | 1998 |
| Methylmercury exposure and neurological outcomes in Taiji residents accustomed to consuming whale meat M Nakamura, N Hachiya, K Murata, I Nakanishi, T Kondo, A Yasutake, ... Environment international 68, 25-32, 2014 | 55 | 2014 |
| Methylmercury causes blood-brain barrier damage in rats via upregulation of vascular endothelial growth factor expression T Takahashi, M Fujimura, M Koyama, M Kanazawa, F Usuki, M Nishizawa, ... PLoS One 12 (1), e0170623, 2017 | 51 | 2017 |
| Differential signaling pathways following oxidative stress in mutant myotonin protein kinase cDNA-transfected C2C12 cell lines F Usuki, N Takahashi, N Sasagawa, S Ishiura Biochemical and biophysical research communications 267 (3), 739-743, 2000 | 49 | 2000 |
| Differing effects of toxicants (methylmercury, inorganic mercury, lead, amyloid β, and rotenone) on cultured rat cerebrocortical neurons: differential expression of rho … M Fujimura, F Usuki Toxicological Sciences 126 (2), 506-514, 2012 | 48 | 2012 |
| Site-specific neural hyperactivity via the activation of MAPK and PKA/CREB pathways triggers neuronal degeneration in methylmercury-intoxicated mice M Fujimura, F Usuki Toxicology letters 271, 66-73, 2017 | 45 | 2017 |
| Ataxia caused by mutations in the α-tocopherol transfer protein gene F Usuki, K Maruyama Journal of Neurology, Neurosurgery & Psychiatry 69 (2), 254-256, 2000 | 45 | 2000 |
| Beneficial effects of mild lifelong dietary restriction on skeletal muscle: prevention of age-related mitochondrial damage, morphological changes, and vulnerability to a … F Usuki, A Yasutake, F Umehara, I Higuchi Acta neuropathologica 108, 1-9, 2004 | 43 | 2004 |
| Low concentrations of methylmercury inhibit neural progenitor cell proliferation associated with up-regulation of glycogen synthase kinase 3β and subsequent degradation of … M Fujimura, F Usuki Toxicology and Applied Pharmacology 288 (1), 19-25, 2015 | 39 | 2015 |
| Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity F Usuki, A Yamashita, T Shiraishi, A Shiga, O Onodera, I Higuchi, S Ohno Proceedings of the National Academy of Sciences 110 (37), 15037-15042, 2013 | 38 | 2013 |
| Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: in vitro and in vivo effects of TrkA pathway activators M Fujimura, F Usuki Toxicology and Applied Pharmacology 282 (3), 259-266, 2015 | 37 | 2015 |
| The effect of methylmercury on skeletal muscle in the rat: a histopathological study F Usuki, A Yasutake, M Matsumoto, F Umehara, I Higuchi Toxicology letters 94 (3), 227-232, 1998 | 35 | 1998 |
