|Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity|
C Angermueller, SJ Clark, HJ Lee, IC Macaulay, MJ Teng, TX Hu, ...
Nature methods 13 (3), 229-232, 2016
|Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity|
SJ Clark, HJ Lee, SA Smallwood, G Kelsey, W Reik
Genome biology 17 (1), 72, 2016
|scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells|
SJ Clark, R Argelaguet, CA Kapourani, TM Stubbs, HJ Lee, ...
Nature communications 9 (1), 781, 2018
|Genome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation|
JR Peat, W Dean, SJ Clark, F Krueger, SA Smallwood, G Ficz, JK Kim, ...
Cell reports 9 (6), 1990-2000, 2014
|Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity|
SJ Clark, M Falchi, B Olsson, P Jacobson, S Cauchi, B Balkau, M Marre, ...
Obesity 20 (1), 178-185, 2012
|Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq)|
SJ Clark, SA Smallwood, HJ Lee, F Krueger, W Reik, G Kelsey
Nature protocols 12 (3), 534-547, 2017
|Continuous histone replacement by Hira is essential for normal transcriptional regulation and de novo DNA methylation during mouse oogenesis|
B Nashun, PWS Hill, SA Smallwood, G Dharmalingam, R Amouroux, ...
Molecular cell 60 (4), 611-625, 2015
|Genome-scale oscillations in DNA methylation during exit from pluripotency|
S Rulands, HJ Lee, SJ Clark, C Angermueller, SA Smallwood, F Krueger, ...
bioRxiv, 338822, 2018
|Joint Profiling Of Chromatin Accessibility, DNA Methylation And Transcription In Single Cells|
SJ Clark, R Argelaguet, CA Kapourani, TM Stubbs, HJ Lee, F Krueger, ...
bioRxiv, 138685, 2017
|Combined single cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity|
SM Linker, L Urban, S Clark, M Chhatriwala, S Amatya, D McCarthy, ...
bioRxiv, 328138, 2018
|Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in muscle stem cells|
I Hernando-Herraez, B Evano, T Stubbs, PH Commere, S Clark, ...
bioRxiv, 500900, 2018
|Single cell multi-omics profiling reveals a hierarchical epigenetic landscape during mammalian germ layer specification|
R Argelaguet, H Mohammed, S Clark, C Stapel, C Krueger, CA Kapourani, ...
bioRxiv, 519207, 2019
|Setting the epigenetic stage for differentiation: a collective phenomenon|
F Olmeda, S Clark, T Lohoff, H Lee, W Reik, S Rulands
Bulletin of the American Physical Society, 2019
|Collective oscillations of DNA methylation during exit from pluripotency|
S Rulands, H Lee, S Clark, H Mohammed, B Simons, W Reik
Bulletin of the American Physical Society, 2018
|The Genetic Mechanisms Underlying Human Obesity|
Imperial College London, 2013
|Association of variants in the Sirtuin 1 (SIRT1) gene with severe obesity|
S Clark, M Falchi, B Olsson, D Meyre, J Andersson, B Balkau, M Marre, ...
JOURNAL OF MEDICAL GENETICS 46, S65-S65, 2009
|Continuous histone replacement by Hira is essential for normal transcriptional regulation and efficient de novo DNA methylation during mouse oogenesis|
P Hajkova, B Nashun, PWS Hill, S Smallwood, G Dharmalingam, ...
Elsevier (Cell Press), 0