| A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ... Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017 | 300 | 2017 |
| Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, ... Proceedings of the National Academy of Sciences 114 (2), E200-E208, 2017 | 206 | 2017 |
| Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ... Nature communications 10 (1), 225, 2019 | 133 | 2019 |
| Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ... ACS chemical biology 13 (8), 2308-2319, 2018 | 104 | 2018 |
| Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, ... Science advances 6 (45), eabb5924, 2020 | 102 | 2020 |
| Rational design of a conformation-specific antibody for the quantification of Aβ oligomers FA Aprile, P Sormanni, M Podpolny, S Chhangur, LM Needham, ... Proceedings of the National Academy of Sciences 117 (24), 13509-13518, 2020 | 73 | 2020 |
| Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, ... Journal of neuroscience methods 306, 57-67, 2018 | 57 | 2018 |
| Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, ... Communications biology 3 (1), 435, 2020 | 52 | 2020 |
| Impaired brain dopamine and serotonin release and uptake in wistar rats following treatment with carboplatin SV Kaplan, RA Limbocker, RC Gehringer, JL Divis, GL Osterhaus, ... ACS chemical neuroscience 7 (6), 689-699, 2016 | 41 | 2016 |
| Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers R Limbocker, R Staats, S Chia, FS Ruggeri, B Mannini, CK Xu, M Perni, ... Frontiers in Neuroscience 15, 680026, 2021 | 38 | 2021 |
| Squalamine and trodusquemine: Two natural products for neurodegenerative diseases, from physical chemistry to the clinic R Limbocker, S Errico, D Barbut, TPJ Knowles, M Vendruscolo, F Chiti, ... Natural Product Reports 39 (4), 742-753, 2022 | 32 | 2022 |
| Therapeutic strategies to reduce the toxicity of misfolded protein oligomers RP Kreiser, AK Wright, NR Block, JE Hollows, LT Nguyen, K LeForte, ... International Journal of Molecular Sciences 21 (22), 8651, 2020 | 26 | 2020 |
| Localized drug application and sub-second voltammetric dopamine release measurements in a brain slice perfusion device M Sun, SV Kaplan, RC Gehringer, RA Limbocker, MA Johnson Analytical chemistry 86 (9), 4151-4156, 2014 | 25 | 2014 |
| A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease T Ikenoue, FA Aprile, P Sormanni, FS Ruggeri, M Perni, GT Heller, ... Scientific reports 10 (1), 15280, 2020 | 17 | 2020 |
| Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease M Perni, A Van der Goot, R Limbocker, TJ Van Ham, FA Aprile, CK Xu, ... Frontiers in Cell and Developmental Biology 9, 552549, 2021 | 15 | 2021 |
| Rationally designed antibodies as research tools to study the structure–toxicity relationship of amyloid-β oligomers R Limbocker, B Mannini, R Cataldi, S Chhangur, AK Wright, RP Kreiser, ... International Journal of Molecular Sciences 21 (12), 4542, 2020 | 13 | 2020 |
| Impact of COVID-19 on general chemistry education at the United States Military Academy CK Nguyen, DR DeNeve, LT Nguyen, R Limbocker Journal of Chemical Education 97 (9), 2922-2927, 2020 | 12 | 2020 |
| Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response P Joshi, M Perni, R Limbocker, B Mannini, S Casford, S Chia, J Habchi, ... Communications Biology 4 (1), 843, 2021 | 10 | 2021 |
| Characterization of pairs of toxic and nontoxic misfolded protein oligomers elucidates the structural determinants of oligomer toxicity in protein misfolding diseases R Limbocker, N Cremades, R Cascella, PM Tessier, M Vendruscolo, ... Accounts of Chemical Research 56 (12), 1395-1405, 2023 | 8 | 2023 |
| A brain-permeable aminosterol regulates cell membranes to mitigate the toxicity of diverse pore-forming agents RP Kreiser, AK Wright, LR Sasser, DJ Rinauro, JM Gabriel, CM Hsu, ... ACS Chemical Neuroscience 13 (8), 1219-1231, 2022 | 7 | 2022 |
Michele VendruscoloProfessor of Biophysics, University of CambridgeVerified email at cam.ac.uk
