| Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells AS Plump, JD Smith, T Hayek, K Aalto-Setälä, A Walsh, JG Verstuyft, ... Cell 71 (2), 343-353, 1992 | 2885 | 1992 |
| FinnGen provides genetic insights from a well-phenotyped isolated population MI Kurki, J Karjalainen, P Palta, TP Sipilä, K Kristiansson, KM Donner, ... Nature 613 (7944), 508-518, 2023 | 786 | 2023 |
| A primer-guided nucleotide incorporation assay in the genotyping of apolipoprotein E AC Syvänen, K Aalto-Setälä, L Harju, K Kontula, H Söderlund Genomics 8 (4), 684-692, 1990 | 578 | 1990 |
| Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with … K Aalto-Setälä, EA Fisher, X Chen, T Chajek-Shaul, T Hayek, R Zechner, ... The Journal of clinical investigation 90 (5), 1889-1900, 1992 | 527 | 1992 |
| Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density … PH Weinstock, CL Bisgaier, K Aalto-Setälä, H Radner, R Ramakrishnan, ... The Journal of clinical investigation 96 (6), 2555-2568, 1995 | 369 | 1995 |
| Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture AL Lahti, VJ Kujala, H Chapman, AP Koivisto, M Pekkanen-Mattila, ... Disease models & mechanisms 5 (2), 220-230, 2012 | 356 | 2012 |
| FinnGen: Unique genetic insights from combining isolated population and national health register data MI Kurki, J Karjalainen, P Palta, TP Sipilä, K Kristiansson, K Donner, ... MedRxiv, 2022.03. 03.22271360, 2022 | 354 | 2022 |
| Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA M Julkunen, R Koistinen, K Aalto-Setälä, M Seppälä, OA Jänne, K Kontula FEBS letters 236 (2), 295-302, 1988 | 259 | 1988 |
| Cardiac differentiation of pluripotent stem cells K Rajala, M Pekkanen-Mattila, K Aalto-Setälä Stem cells international 2011, 2011 | 194 | 2011 |
| Dietary fat increases high density lipoprotein (HDL) levels both by increasing the transport rates and decreasing the fractional catabolic rates of HDL cholesterol ester and … T Hayek, Y Ito, N Azrolan, RB Verdery, K Aalto-Setälä, A Walsh, ... The Journal of clinical investigation 91 (4), 1665-1671, 1993 | 184 | 1993 |
| A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells K Rajala, B Lindroos, SM Hussein, RS Lappalainen, M Pekkanen-Mattila, ... PloS one 5 (4), e10246, 2010 | 181 | 2010 |
| Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations K Kujala, J Paavola, A Lahti, K Larsson, M Pekkanen-Mattila, M Viitasalo, ... Public Library of Science 7 (9), e44660, 2012 | 157 | 2012 |
| Computational models of ventricular-and atrial-like human induced pluripotent stem cell derived cardiomyocytes M Paci, J Hyttinen, K Aalto-Setälä, S Severi Annals of biomedical engineering 41, 2334-2348, 2013 | 150 | 2013 |
| Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia CI Spencer, S Baba, K Nakamura, EA Hua, MAF Sears, C Fu, J Zhang, ... Stem cell reports 3 (2), 269-281, 2014 | 140 | 2014 |
| Further characterization of the metabolic properties of triglyceride-rich lipoproteins from human and mouse apoC-III transgenic mice. K Aalto-Setälä, PH Weinstock, CL Bisgaier, L Wu, JD Smith, JL Breslow Journal of lipid research 37 (8), 1802-1811, 1996 | 137 | 1996 |
| Lipoproteins and their genetic variation in subjects with and without angiographically verified coronary artery disease. MS Nieminen, KJ Mattila, K Aalto-Setälä, T Kuusi, K Kontula, ... Arteriosclerosis and Thrombosis: A Journal of Vascular Biology 12 (1), 58-69, 1992 | 117 | 1992 |
| Video image-based analysis of single human induced pluripotent stem cell derived cardiomyocyte beating dynamics using digital image correlation A Ahola, AL Kiviaho, K Larsson, M Honkanen, K Aalto-Setälä, J Hyttinen Biomedical engineering online 13, 1-18, 2014 | 115 | 2014 |
| Apolipoprotein E polymorphism determined by restriction enzyme analysis of DNA amplified by polymerase chain reaction: convenient alternative to phenotyping by isoelectric focusing K Kontula, K Aalto-Setälä, T Kuusi, L Hämäläinen, AC Syvänen Clinical chemistry 36 (12), 2087-2092, 1990 | 115 | 1990 |
| The familial hypercholesterolemia (FH)-North Karelia mutation of the low density lipoprotein receptor gene deletes seven nucleotides of exon 6 and is a common cause of FH in … UM Koivisto, H Turtola, K Aalto-Setälä, B Top, RR Frants, PT Kovanen, ... The Journal of clinical investigation 90 (1), 219-228, 1992 | 110 | 1992 |
| Finnish type of low density lipoprotein receptor gene mutation (FH-Helsinki) deletes exons encoding the carboxy-terminal part of the receptor and creates an internalization … K Aalto-Setälä, E Helve, PT Kovanen, K Kontula The Journal of clinical investigation 84 (2), 499-505, 1989 | 108 | 1989 |
