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| The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia BJ Thompson, S Buonamici, ML Sulis, T Palomero, T Vilimas, G Basso, ... The Journal of experimental medicine 204 (8), 1825-1835, 2007 | 558 | 2007 |
| Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma S Buonamici, J Williams, M Morrissey, A Wang, R Guo, A Vattay, K Hsiao, ... Science translational medicine 2 (51), 51ra70-51ra70, 2010 | 523 | 2010 |
| Molecular pathogenesis of T-cell leukaemia and lymphoma I Aifantis, E Raetz, S Buonamici Nature Reviews Immunology 8 (5), 380-390, 2008 | 522 | 2008 |
| The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1 AA Wylie, J Schoepfer, W Jahnke, SW Cowan-Jacob, A Loo, P Furet, ... Nature 543 (7647), 733-737, 2017 | 491 | 2017 |
| H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers M Seiler, A Yoshimi, R Darman, B Chan, G Keaney, M Thomas, ... Nature medicine 24 (4), 497-504, 2018 | 465 | 2018 |
| Cancer-associated SF3B1 hotspot mutations induce cryptic 3′ splice site selection through use of a different branch point RB Darman, M Seiler, AA Agrawal, KH Lim, S Peng, D Aird, SL Bailey, ... Cell reports 13 (5), 1033-1045, 2015 | 447 | 2015 |
| A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia A Klinakis, C Lobry, O Abdel-Wahab, P Oh, H Haeno, S Buonamici, ... Nature 473 (7346), 230-233, 2011 | 426 | 2011 |
| Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia T Vilimas, J Mascarenhas, T Palomero, M Mandal, S Buonamici, F Meng, ... Nature medicine 13 (1), 70-77, 2007 | 420 | 2007 |
| Somatic mutational landscape of splicing factor genes and their functional consequences across 33 cancer types M Seiler, S Peng, AA Agrawal, J Palacino, T Teng, P Zhu, PG Smith, ... Cell reports 23 (1), 282-296. e4, 2018 | 378 | 2018 |
| Physiologic expression of Sf3b1K700E causes impaired erythropoiesis, aberrant splicing, and sensitivity to therapeutic spliceosome modulation EA Obeng, RJ Chappell, M Seiler, MC Chen, DR Campagna, PJ Schmidt, ... Cancer cell 30 (3), 404-417, 2016 | 374 | 2016 |
| Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins SCW Lee, H Dvinge, E Kim, H Cho, JB Micol, YR Chung, BH Durham, ... Nature medicine 22 (6), 672-678, 2016 | 358 | 2016 |
| Discovery of asciminib (ABL001), an allosteric inhibitor of the tyrosine kinase activity of BCR-ABL1 J Schoepfer, W Jahnke, G Berellini, S Buonamici, S Cotesta, ... Journal of Medicinal Chemistry 61 (18), 8120-8135, 2018 | 341 | 2018 |
| CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia S Buonamici, T Trimarchi, MG Ruocco, L Reavie, S Cathelin, BG Mar, ... Nature 459 (7249), 1000-1004, 2009 | 292 | 2009 |
| A crucial requirement for Hedgehog signaling in small cell lung cancer KS Park, LG Martelotto, M Peifer, ML Sos, AN Karnezis, MR Mahjoub, ... Nature medicine 17 (11), 1504-1508, 2011 | 285 | 2011 |
| Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway Z Jagani, EL Mora-Blanco, CG Sansam, ES McKenna, B Wilson, D Chen, ... Nature medicine 16 (12), 1429-1433, 2010 | 257 | 2010 |
| EVI1 induces myelodysplastic syndrome in mice S Buonamici, D Li, Y Chi, R Zhao, X Wang, L Brace, H Ni, ... The Journal of clinical investigation 114 (5), 713-719, 2004 | 234 | 2004 |
| Hedgehog signaling is dispensable for adult hematopoietic stem cell function J Gao, S Graves, U Koch, S Liu, V Jankovic, S Buonamici, A El Andaloussi, ... Cell stem cell 4 (6), 548-558, 2009 | 231 | 2009 |
| Transcriptomic characterization of SF3B1 mutation reveals its pleiotropic effects in chronic lymphocytic leukemia L Wang, AN Brooks, J Fan, Y Wan, R Gambe, S Li, S Hergert, S Yin, ... Cancer cell 30 (5), 750-763, 2016 | 210 | 2016 |
| Synthetic lethal and convergent biological effects of cancer-associated spliceosomal gene mutations SCW Lee, K North, E Kim, E Jang, E Obeng, SX Lu, B Liu, D Inoue, ... Cancer cell 34 (2), 225-241. e8, 2018 | 207 | 2018 |
