Linda Wooldridge
Linda Wooldridge
Chair in Translational Immunology
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A single autoimmune T cell receptor recognizes more than a million different peptides
L Wooldridge, J Ekeruche-Makinde, H Van Den Berg, A Skowera, ...
Journal of Biological Chemistry 287 (2), 1168-1177, 2012
Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses
DA Price, JM Brenchley, LE Ruff, MR Betts, BJ Hill, M Roederer, RA Koup, ...
The Journal of experimental medicine 202 (10), 1349-1361, 2005
Structural and kinetic basis for heightened immunogenicity of T cell vaccines
JL Chen, G Stewart-Jones, G Bossi, NM Lissin, L Wooldridge, EML Choi, ...
The Journal of experimental medicine 201 (8), 1243-1255, 2005
Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties
B Laugel, HA van den Berg, E Gostick, DK Cole, L Wooldridge, J Boulter, ...
Journal of Biological Chemistry 282 (33), 23799-23810, 2007
Tricks with tetramers: how to get the most from multimeric peptide–MHC
L Wooldridge, A Lissina, DK Cole, HA Van Den Berg, DA Price, AK Sewell
Immunology 126 (2), 147-164, 2009
Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes
AM Bulek, DK Cole, A Skowera, G Dolton, S Gras, F Madura, A Fuller, ...
Nature immunology 13 (3), 283-289, 2012
Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface
L Wooldridge, HA van den Berg, M Glick, E Gostick, B Laugel, ...
Journal of Biological Chemistry 280 (30), 27491-27501, 2005
Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers
A Lissina, K Ladell, A Skowera, M Clement, E Edwards, R Seggewiss, ...
Journal of immunological methods 340 (1), 11-24, 2009
Profound inhibition of antigen-specific T-cell effector functions by dasatinib
R Weichsel, C Dix, L Wooldridge, M Clement, A Fenton-May, AK Sewell, ...
Clinical Cancer Research 14 (8), 2484-2491, 2008
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
DK Cole, AM Bulek, G Dolton, AJ Schauenberg, B Szomolay, W Rittase, ...
The Journal of clinical investigation 126 (6), 2191-2204, 2016
Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition
DK Cole, ESJ Edwards, KK Wynn, M Clement, JJ Miles, K Ladell, ...
The Journal of Immunology 185 (4), 2600-2610, 2010
Escape from highly effective public CD8+ T-cell clonotypes by HIV
MC Iglesias, JR Almeida, S Fastenackels, DJ van Bockel, M Hashimoto, ...
Blood, The Journal of the American Society of Hematology 118 (8), 2138-2149, 2011
Peptide length determines the outcome of TCR/peptide-MHCI engagement
J Ekeruche-Makinde, JJ Miles, HA Van Den Berg, A Skowera, DK Cole, ...
Blood, The Journal of the American Society of Hematology 121 (7), 1112-1123, 2013
High avidity antigen-specific CTL identified by CD8-independent tetramer staining
EML Choi, JL Chen, L Wooldridge, M Salio, A Lissina, N Lissin, ...
The Journal of Immunology 171 (10), 5116-5123, 2003
The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities
SL Hutchinson, L Wooldridge, S Tafuro, B Laugel, M Glick, JM Boulter, ...
Journal of Biological Chemistry 278 (27), 24285-24293, 2003
Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection
JJ Miles, AM Bulek, DK Cole, E Gostick, AJA Schauenburg, G Dolton, ...
PLoS pathogens 6 (11), e1001198, 2010
CD8 controls T cell cross-reactivity
L Wooldridge, B Laugel, J Ekeruche, M Clement, HA van den Berg, ...
The Journal of Immunology 185 (8), 4625-4632, 2010
Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region
L Wooldridge, A Lissina, J Vernazza, E Gostick, B Laugel, SL Hutchinson, ...
European journal of immunology 37 (5), 1323-1333, 2007
The molecular determinants of CD 8 co‐receptor function
DK Cole, B Laugel, M Clement, DA Price, L Wooldridge, AK Sewell
Immunology 137 (2), 139-148, 2012
Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity
RR Knight, D Kronenberg, M Zhao, GC Huang, M Eichmann, A Bulek, ...
Diabetes 62 (1), 205-213, 2013
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