raffaele de francesco
raffaele de francesco
Fondazione INGM - Istituto Nazionale Genetica Molecolare, Milano.
Verified email at ingm.org
TitleCited byYear
Identification and properties of the RNA‐dependent RNA polymerase of hepatitis C virus.
SE Behrens, L Tomei, R De Francesco
The EMBO journal 15 (1), 12-22, 1996
8981996
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
S Bressanelli, L Tomei, A Roussel, I Incitti, RL Vitale, M Mathieu, ...
Proceedings of the National Academy of Sciences 96 (23), 13034-13039, 1999
6651999
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor
A Vannini, C Volpari, G Filocamo, EC Casavola, M Brunetti, D Renzoni, ...
Proceedings of the National Academy of Sciences 101 (42), 15064-15069, 2004
6022004
Challenges and successes in developing new therapies for hepatitis C
R De Francesco, G Migliaccio
Nature 436 (7053), 953, 2005
5912005
NS3 is a serine protease required for processing of hepatitis C virus polyprotein.
L Tomei, C Failla, E Santolini, R De Francesco, N La Monica
Journal of virology 67 (7), 4017-4026, 1993
5141993
Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins.
C Failla, L Tomei, R De Francesco
Journal of virology 68 (6), 3753-3760, 1994
4671994
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides
S Bressanelli, L Tomei, FA Rey, R De Francesco
Journal of virology 76 (7), 3482-3492, 2002
4002002
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases
A Lahm, C Paolini, M Pallaoro, MC Nardi, P Jones, P Neddermann, ...
Proceedings of the National Academy of Sciences 104 (44), 17335-17340, 2007
3972007
Inhibition of hepatitis C virus RNA replication by 2′-modified nucleoside analogs
SS Carroll, JE Tomassini, M Bosserman, K Getty, MW Stahlhut, AB Eldrup, ...
Journal of Biological Chemistry 278 (14), 11979-11984, 2003
3722003
The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA
A Vannini, C Volpari, C Gargioli, E Muraglia, R Cortese, R De Francesco, ...
The EMBO journal 21 (17), 4393-4401, 2002
3602002
Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro
G Migliaccio, JE Tomassini, SS Carroll, L Tomei, S Altamura, B Bhat, ...
Journal of Biological Chemistry 278 (49), 49164-49170, 2003
3162003
Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase
R De Francesco, L Tomei, S Altamura, V Summa, G Migliaccio
Antiviral research 58 (1), 1-16, 2003
3122003
Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 Ċ resolution structure in a hexagonal crystal form
Y Yan, Y Li, S Munshi, V Sardana, JL Cole, M Sardana, LC Kuo, Z Chen, ...
Protein Science 7 (4), 837-847, 1998
3111998
Product inhibition of the hepatitis C virus NS3 protease
C Steinkühler, G Biasiol, M Brunetti, A Urbani, U Koch, R Cortese, A Pessi, ...
Biochemistry 37 (25), 8899-8905, 1998
2811998
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain
MJ Bottomley, PL Surdo, P Di Giovine, A Cirillo, R Scarpelli, F Ferrigno, ...
Journal of Biological Chemistry 283 (39), 26694-26704, 2008
2502008
Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b
RL Rossi, G Rossetti, L Wenandy, S Curti, A Ripamonti, RJP Bonnal, ...
Nature immunology 12 (8), 796, 2011
2322011
Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus
P Gallinari, D Brennan, C Nardi, M Brunetti, L Tomei, C Steinkühler, ...
Journal of virology 72 (8), 6758-6769, 1998
2271998
Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products
P Ingallinella, S Altamura, E Bianchi, M Taliani, R Ingenito, R Cortese, ...
Biochemistry 37 (25), 8906-8914, 1998
2261998
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8–substrate complex
A Vannini, C Volpari, P Gallinari, P Jones, M Mattu, A Carfí, ...
EMBO reports 8 (9), 879-884, 2007
2122007
Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
L Tomei, S Altamura, L Bartholomew, A Biroccio, A Ceccacci, L Pacini, ...
Journal of Virology 77 (24), 13225-13231, 2003
2072003
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