Alessio Lodola
Alessio Lodola
Associate Professor of Medicinal Chemistry, University of Parma
Verified email at unipr.it - Homepage
TitleCited byYear
Cyclohexylcarbamic acid 3 ‘-or 4 ‘-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: Synthesis, quantitative structure− activity relationships, andá…
M Mor, S Rivara, A Lodola, PV Plazzi, G Tarzia, A Duranti, A Tontini, ...
Journal of medicinal chemistry 47 (21), 4998-5008, 2004
2712004
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation
C Solorzano, C Zhu, N Battista, G Astarita, A Lodola, S Rivara, M Mor, ...
Proceedings of the National Academy of Sciences 106 (49), 20966-20971, 2009
1832009
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation
C Solorzano, C Zhu, N Battista, G Astarita, A Lodola, S Rivara, M Mor, ...
Proceedings of the National Academy of Sciences 106 (49), 20966-20971, 2009
1832009
A catalytically silent FAAH-1 variant drives anandamide transport in neurons
J Fu, G Bottegoni, O Sasso, R Bertorelli, W Rocchia, M Masetti, A Guijarro, ...
Nature neuroscience 15 (1), 64, 2012
1702012
5-Benzylidene-hydantoins as new EGFR inhibitors with antiproliferative activity
C Carmi, A Cavazzoni, V Zuliani, A Lodola, F Bordi, PV Plazzi, RR Alfieri, ...
Bioorganic & medicinal chemistry letters 16 (15), 4021-4025, 2006
882006
Discovery of potent and reversible monoacylglycerol lipase inhibitors
AR King, EY Dotsey, A Lodola, KM Jung, A Ghomian, Y Qiu, J Fu, M Mor, ...
Chemistry & biology 16 (10), 1045-1052, 2009
872009
A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone‐based enzyme inhibitors
AR King, A Lodola, C Carmi, J Fu, M Mor, D Piomelli
British journal of pharmacology 157 (6), 974-983, 2009
702009
N-(substituted-anilinoethyl) amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands
S Rivara, A Lodola, M Mor, A Bedini, G Spadoni, V Lucini, M Pannacci, ...
Journal of medicinal chemistry 50 (26), 6618-6626, 2007
692007
Conformational effects in enzyme catalysis: reaction via a high energy conformation in fatty acid amide hydrolase
A Lodola, M Mor, J Zurek, G Tarzia, D Piomelli, JN Harvey, AJ Mulholland
Biophysical journal 92 (2), L20-L22, 2007
692007
Novel irreversible epidermal growth factor receptor inhibitors by chemical modulation of the cysteine-trap portion
C Carmi, A Cavazzoni, S Vezzosi, F Bordi, F Vacondio, C Silva, S Rivara, ...
Journal of medicinal chemistry 53 (5), 2038-2050, 2010
662010
Synthesis and quantitative structure− activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates
M Mor, A Lodola, S Rivara, F Vacondio, A Duranti, A Tontini, S Sanchini, ...
Journal of medicinal chemistry 51 (12), 3487-3498, 2008
662008
Synthesis and structure–activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring
G Tarzia, A Duranti, G Gatti, G Piersanti, A Tontini, S Rivara, A Lodola, ...
ChemMedChem: Chemistry Enabling Drug Discovery 1 (1), 130-139, 2006
642006
Synthesis and Structure−Activity Relationships of N-(2-Oxo-3-oxetanyl)amides as N-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors
C Solorzano, F Antonietti, A Duranti, A Tontini, S Rivara, A Lodola, ...
Journal of medicinal chemistry 53 (15), 5770-5781, 2010
632010
Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation
C Giorgio, IH Mohamed, L Flammini, E Barocelli, M Incerti, A Lodola, ...
PLoS One 6 (3), e18128, 2011
612011
Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines
A Cavazzoni, RR Alfieri, C Carmi, V Zuliani, M Galetti, C Fumarola, ...
Molecular cancer therapeutics 7 (2), 361-370, 2008
602008
Irreversible inhibition of epidermal growth factor receptor activity by 3-aminopropanamides
C Carmi, E Galvani, F Vacondio, S Rivara, A Lodola, S Russo, S Aiello, ...
Journal of medicinal chemistry 55 (5), 2251-2264, 2012
592012
QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation
A Lodola, M Mor, JC Hermann, G Tarzia, D Piomelli, AJ Mulholland
Chemical Communications, 4399-4401, 2005
572005
A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations
A Lodola, D Branduardi, M De Vivo, L Capoferri, M Mor, D Piomelli, ...
PLoS One 7 (2), e32397, 2012
532012
Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling
A Lodola, M Mor, S Rivara, C Christov, G Tarzia, D Piomelli, ...
Chemical Communications, 214-216, 2008
512008
5-Benzylidene-hydantoins: Synthesis and antiproliferative activity on A549 lung cancer cell line
V Zuliani, C Carmi, M Rivara, M Fantini, A Lodola, F Vacondio, F Bordi, ...
European journal of medicinal chemistry 44 (9), 3471-3479, 2009
452009
The system can't perform the operation now. Try again later.
Articles 1–20