| Cation–π interactions in protein–ligand binding: Theory and data-mining reveal different roles for lysine and arginine K Kumar, SM Woo, T Siu, WA Cortopassi, F Duarte, RS Paton Chemical science 9 (10), 2655-2665, 2018 | 221 | 2018 |
| Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies J Penna-Coutinho, WA Cortopassi, AA Oliveira, TCC França, AU Krettli PloS one 6 (7), e21237, 2011 | 164 | 2011 |
| Small molecule inhibitors of bromodomain–acetyl-lysine interactions M Brand, AM Measures, BG Wilson, WA Cortopassi, R Alexander, ... ACS chemical biology 10 (1), 22-39, 2015 | 160 | 2015 |
| A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced‐Fit Pocket Stabilized by a Cation–π Interaction TPC Rooney, P Filippakopoulos, O Fedorov, S Picaud, WA Cortopassi, ... Angewandte Chemie International Edition 53 (24), 6126-6130, 2014 | 131 | 2014 |
| Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity ACC Aguiar, E Murce, WA Cortopassi, AS Pimentel, MMFS Almeida, ... International Journal for Parasitology: Drugs and Drug Resistance 8 (3), 459-464, 2018 | 103 | 2018 |
| Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasites ACC Aguiar, RM Santos, FJB Figueiredo, WA Cortopassi, AS Pimentel, ... PLoS One 7 (5), e37259, 2012 | 70 | 2012 |
| Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling WK Lin, EL Bolton, WA Cortopassi, Y Wang, F O'Brien, M Maciejewska, ... Journal of Biological Chemistry 292 (32), 13243-13257, 2017 | 59 | 2017 |
| Progranulin stimulates the in vitro maturation of pro-cathepsin D at acidic pH VJ Butler, WA Cortopassi, AR Argouarch, SL Ivry, CS Craik, MP Jacobson, ... Journal of molecular biology 431 (5), 1038-1047, 2019 | 56 | 2019 |
| Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro VJ Butler, WA Cortopassi, S Gururaj, AL Wang, OM Pierce, MP Jacobson, ... Biochemistry 58 (23), 2670-2674, 2019 | 33 | 2019 |
| Cation–π interactions in CREBBP bromodomain inhibition: an electrostatic model for small-molecule binding affinity and selectivity WA Cortopassi, K Kumar, RS Paton Organic & Biomolecular Chemistry 14 (46), 10926-10938, 2016 | 30 | 2016 |
| Atp-Competitive inhibitors midostaurin and avapritinib have distinct resistance profiles in exon 17–mutant kit B Apsel Winger, WA Cortopassi, D Garrido Ruiz, L Ding, K Jang, ... Cancer research 79 (16), 4283-4292, 2019 | 29 | 2019 |
| Matched targeted therapy for pediatric patients with relapsed, refractory, or high-risk leukemias: a report from the LEAP Consortium Y Pikman, SK Tasian, ML Sulis, K Stevenson, TM Blonquist, ... Cancer discovery 11 (6), 1424-1439, 2021 | 25 | 2021 |
| Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response VJ Butler, F Gao, CI Corrales, WA Cortopassi, B Caballero, M Vohra, ... PLoS genetics 15 (8), e1008295, 2019 | 25 | 2019 |
| Dioxygen binding in the active site of histone demethylase JMJD2A and the role of the protein environment WA Cortopassi, R Simion, CE Honsby, TCC França, RS Paton Chemistry–A European Journal 21 (52), 18983-18992, 2015 | 22 | 2015 |
| Docking studies on the binding of quinoline derivatives and hematin to Plasmodium falciparum lactate dehydrogenase WA Cortopassi, AA Oliveira, AP Guimarães, MN Rennó, AU Krettli, ... Journal of Biomolecular Structure and Dynamics 29 (1), 207-218, 2011 | 19 | 2011 |
| Mechanisms of histone lysine-modifying enzymes: A computational perspective on the role of the protein environment WA Cortopassi, K Kumar, F Duarte, AS Pimentel, RS Paton Journal of Molecular Graphics and Modelling 67, 69-84, 2016 | 18 | 2016 |
| Topology and dynamics of the interaction between 5-nitroimidazole radiosensitizers and duplex DNA studied by a combination of docking, molecular dynamic simulations and NMR … TC Ramalho, TCC França, WA Cortopassi, AS Gonçalves, AWS Da Silva, ... Journal of molecular structure 992 (1-3), 65-71, 2011 | 18 | 2011 |
| Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH RA Charafeddine, WA Cortopassi, P Lak, R Tan, RJ McKenney, ... Journal of Biological Chemistry 294 (22), 8779-8790, 2019 | 17 | 2019 |
| Theoretical and Experimental Studies of New Modified Isoflavonoids as Potential Inhibitors of Topoisomerase I from Plasmodium falciparum WA Cortopassi, J Penna-Coutinho, ACC Aguiar, AS Pimentel, ... PloS one 9 (3), e91191, 2014 | 17 | 2014 |
| Controlling intramolecular interactions in the design of selective, high-affinity ligands for the CREBBP bromodomain M Brand, J Clayton, M Moroglu, M Schiedel, S Picaud, JP Bluck, ... Journal of medicinal chemistry 64 (14), 10102-10123, 2021 | 16 | 2021 |
