Gopal Sapkota
Gopal Sapkota
Principal Investigator, University of Dundee
Verified email at dundee.ac.uk - Homepage
Title
Cited by
Cited by
Year
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-β pathways
C Alarcón, AI Zaromytidou, Q Xi, S Gao, J Yu, S Fujisawa, A Barlas, ...
Cell 139 (4), 757-769, 2009
6382009
Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase
BLJ Godber, JJ Doel, GP Sapkota, DR Blake, CR Stevens, R Eisenthal, ...
Journal of Biological Chemistry 275 (11), 7757-7763, 2000
4182000
Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD
AF Baas, J Boudeau, GP Sapkota, L Smit, R Medema, NA Morrice, ...
The EMBO journal 22 (12), 3062-3072, 2003
4172003
Balancing BMP signaling through integrated inputs into the Smad1 linker
G Sapkota, C Alarcón, FM Spagnoli, AH Brivanlou, J Massagué
Molecular cell 25 (3), 441-454, 2007
4082007
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis
MJ Lee, S Thangada, JH Paik, GP Sapkota, N Ancellin, SS Chae, M Wu, ...
Molecular cell 8 (3), 693-704, 2001
3522001
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-β signaling
S Gao, C Alarcón, G Sapkota, S Rahman, PY Chen, N Goerner, ...
Molecular cell 36 (3), 457-468, 2009
3072009
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent protein kinase, but not its farnesylation at …
GP Sapkota, A Kieloch, JM Lizcano, S Lain, JSC Arthur, MR Williams, ...
Journal of Biological Chemistry 276 (22), 19469-19482, 2001
2872001
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo
GP Sapkota, L Cummings, FS Newell, C Armstrong, J Bain, M Frodin, ...
Biochemical Journal 401 (1), 29-38, 2007
2812007
The specificities of small molecule inhibitors of the TGFss and BMP pathways
J Vogt, R Traynor, GP Sapkota
Cellular signalling 23 (11), 1831-1842, 2011
2412011
LKB1, a protein kinase regulating cell proliferation and polarity
J Boudeau, G Sapkota, DR Alessi
FEBS letters 546 (1), 159-165, 2003
2222003
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase
P Douglas, GP Sapkota, N Morrice, Y Yu, AA Goodarzi, D Merkle, K Meek, ...
Biochemical Journal 368 (1), 243-251, 2002
2022002
Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming …
G Sapkota, M Knockaert, C Alarcón, E Montalvo, AH Brivanlou, ...
Journal of Biological Chemistry 281 (52), 40412-40419, 2006
1822006
Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling
M Knockaert, G Sapkota, C Alarcón, J Massagué, AH Brivanlou
Proceedings of the National Academy of Sciences 103 (32), 11940-11945, 2006
1532006
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
GP Sapkota, M Deak, A Kieloch, N Morrice, AA Goodarzi, C Smythe, ...
Biochemical Journal 368 (2), 507-516, 2002
1382002
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz–Jeghers cancer …
GP Sapkota, J Boudeau, M Deak, A Kieloch, N Morrice, DR Alessi
Biochemical Journal 362 (2), 481-490, 2002
1232002
USP11 augments TGFβ signalling by deubiquitylating ALK5
MA Al-Salihi, L Herhaus, T Macartney, GP Sapkota
Open biology 2 (6), 120063, 2012
972012
Phosphatases in SMAD regulation
DL Bruce, GP Sapkota
FEBS letters 586 (14), 1897-1905, 2012
892012
OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3
L Herhaus, M Al-Salihi, T Macartney, S Weidlich, GP Sapkota
Nature communications 4 (1), 1-13, 2013
832013
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
P Cammareri, AM Rose, DF Vincent, J Wang, A Nagano, S Libertini, ...
Nature communications 7 (1), 1-14, 2016
542016
Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)
L Tan, T Nomanbhoy, D Gurbani, M Patricelli, J Hunter, J Geng, ...
Journal of medicinal chemistry 58 (1), 183-196, 2015
522015
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