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Thomas Coudrat
Thomas Coudrat
Computational Chemist @ CSIRO
Verified email at csiro.au
Title
Cited by
Cited by
Year
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
YL Liang, M Khoshouei, M Radjainia, Y Zhang, A Glukhova, J Tarrasch, ...
Nature 546 (7656), 118-123, 2017
4812017
The role of kinetic context in apparent biased agonism at GPCRs
C Klein Herenbrink, DA Sykes, P Donthamsetti, M Canals, T Coudrat, ...
Nature communications 7 (1), 10842, 2016
3202016
Biased agonism of endogenous opioid peptides at the μ-opioid receptor
GL Thompson, JR Lane, T Coudrat, PM Sexton, A Christopoulos, ...
Molecular pharmacology 88 (2), 335-346, 2015
1052015
A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from class B crystal structures
D Wootten, CA Reynolds, C Koole, KJ Smith, JC Mobarec, J Simms, ...
Molecular pharmacology 89 (3), 335-347, 2016
702016
Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor
GL Thompson, JR Lane, T Coudrat, PM Sexton, A Christopoulos, ...
Biochemical pharmacology 113, 70-87, 2016
512016
Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism
S Lei, L Clydesdale, A Dai, X Cai, Y Feng, D Yang, YL Liang, C Koole, ...
Journal of Biological Chemistry 293 (24), 9370-9387, 2018
492018
Improving virtual screening of G protein-coupled receptors via ligand-directed modeling
T Coudrat, J Simms, A Christopoulos, D Wootten, PM Sexton
PLoS computational biology 13 (11), e1005819, 2017
132017
Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening
T Coudrat, A Christopoulos, PM Sexton, D Wootten
PLoS One 12 (4), e0174719, 2017
112017
Prediction of loops in G protein-coupled receptor homology models: effect of imprecise surroundings and constraints
B Arora, T Coudrat, D Wootten, A Christopoulos, SB Noronha, PM Sexton
Journal of Chemical Information and Modeling 56 (4), 671-686, 2016
82016
Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol
KG Harikumar, T Coudrat, AJ Desai, M Dong, DG Dengler, SGB Furness, ...
Frontiers in Endocrinology 12, 789957, 2021
32021
Development of improved methods for predictive modelling of G protein-coupled receptors
T COUDRAT
Monash University, 0
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