Patrick A. Lewis
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
Guidelines for the use and interpretation of assays for monitoring autophagy 1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
Autophagy 17 (1), 1-382, 2021
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
E Greggio, S Jain, A Kingsbury, R Bandopadhyay, P Lewis, A Kaganovich, ...
Neurobiology of disease 23 (2), 329-341, 2006
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
MA Nalls, C Blauwendraat, CL Vallerga, K Heilbron, S Bandres-Ciga, ...
The Lancet Neurology 18 (12), 1091-1102, 2019
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
MJ Devine, M Ryten, P Vodicka, AJ Thomson, T Burdon, H Houlden, ...
Nature communications 2 (1), 1-10, 2011
Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences
C Manzoni, DA Kia, J Vandrovcova, J Hardy, NW Wood, PA Lewis, ...
Briefings in bioinformatics 19 (2), 286-302, 2018
α-Synucleinopathy associated with G51D SNCA mutation: A link between Parkinson’s disease and multiple system atrophy?
AP Kiely, YT Asi, E Kara, P Limousin, H Ling, P Lewis, C Proukakis, ...
Acta neuropathologica 125 (5), 753-769, 2013
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
E Greggio, I Zambrano, A Kaganovich, A Beilina, JM Taymans, V Daniëls, ...
Journal of Biological Chemistry 283 (24), 16906-16914, 2008
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
PA Lewis, E Greggio, A Beilina, S Jain, A Baker, MR Cookson
Biochemical and biophysical research communications 357 (3), 668-671, 2007
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
VS Burchell, DE Nelson, A Sanchez-Martinez, M Delgado-Camprubi, ...
Nature neuroscience 16 (9), 1257-1265, 2013
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
J Deng, PA Lewis, E Greggio, E Sluch, A Beilina, MR Cookson
Proceedings of the National Academy of Sciences 105 (5), 1499-1504, 2008
The genetics of Parkinson's syndromes: a critical review
J Hardy, P Lewis, T Revesz, A Lees, C Paisan-Ruiz
Current opinion in genetics & development 19 (3), 254-265, 2009
DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA
S Camargos, S Scholz, J Simón-Sánchez, C Paisán-Ruiz, P Lewis, ...
The Lancet Neurology 7 (3), 207-215, 2008
Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS‐1 mutations that lead to exceptionally high amyloid‐β concentrations
H Houlden, M Baker, E McGowan, P Lewis, M Hutton, R Crook, NW Wood, ...
Annals of neurology 48 (5), 806-808, 2000
Genetic and phenotypic characterization of complex hereditary spastic paraplegia
E Kara, A Tucci, C Manzoni, DS Lynch, M Elpidorou, C Bettencourt, ...
Brain 139 (7), 1904-1918, 2016
Inhibition of LRRK2 kinase activity stimulates macroautophagy
C Manzoni, A Mamais, S Dihanich, R Abeti, MPM Soutar, H Plun-Favreau, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1833 (12), 2900-2910, 2013
Cancer and neurodegeneration: between the devil and the deep blue sea
H Plun-Favreau, PA Lewis, J Hardy, LM Martins, NW Wood
PLoS Genet 6 (12), e1001257, 2010
Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase
A Mudher, S Chapman, J Richardson, A Asuni, G Gibb, C Pollard, ...
Journal of Neuroscience 21 (14), 4987-4995, 2001
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration
E Tsika, L Glauser, R Moser, A Fiser, G Daniel, UM Sheerin, A Lees, ...
Human molecular genetics 23 (17), 4621-4638, 2014
Cell-free assays for γ-secretase activity
C McLendon, TP Xin, C Ziani-Cherif, MP Murphy, KA Findlay, PA Lewis, ...
The FASEB Journal 14 (15), 2383-2386, 2000
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