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Jean Paul Chadarevian
Jean Paul Chadarevian
Unknown affiliation
Verified email at uci.edu
Title
Cited by
Cited by
Year
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease
A McQuade, YJ Kang, J Hasselmann, A Jairaman, A Sotelo, M Coburn, ...
Nature communications 11 (1), 5370, 2020
2052020
Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease
C Claes, EP Danhash, J Hasselmann, JP Chadarevian, SK Shabestari, ...
Molecular neurodegeneration 16, 1-11, 2021
762021
Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice
SK Shabestari, S Morabito, EP Danhash, A McQuade, JR Sanchez, ...
Cell reports 39 (11), 2022
632022
A chemical-genetic approach reveals the distinct roles of GSK3α and GSK3β in regulating embryonic stem cell fate
X Chen, R Wang, X Liu, Y Wu, T Zhou, Y Yang, A Perez, YC Chen, L Hu, ...
Developmental cell 43 (5), 563-576. e4, 2017
352017
TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia
A Jairaman, A McQuade, A Granzotto, YJ Kang, JP Chadarevian, ...
Elife 11, e73021, 2022
322022
Cytoplasmic and nuclear TAZ exert distinct functions in regulating primed pluripotency
X Zhou, JP Chadarevian, B Ruiz, QL Ying
Stem cell reports 9 (3), 732-741, 2017
312017
Engineering an inhibitor-resistant human CSF1R variant for microglia replacement
JP Chadarevian, SI Lombroso, GC Peet, J Hasselmann, C Tu, DE Marzan, ...
Journal of Experimental Medicine 220 (3), e20220857, 2022
222022
The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model
C Claes, WE England, EP Danhash, S Kiani Shabestari, A Jairaman, ...
Alzheimer's & Dementia 18 (10), 1765-1778, 2022
222022
The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C
JV Pluvinage, J Sun, C Claes, RA Flynn, MS Haney, T Iram, X Meng, ...
Science translational medicine 13 (622), eabg2919, 2021
212021
A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: Therapeutic efficacy in PS19 mice
A Hovakimyan, T Antonyan, SK Shabestari, O Svystun, G Chailyan, ...
Scientific reports 9 (1), 15455, 2019
192019
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease. Nat. Commun. 11, 5370
A McQuade, YJ Kang, J Hasselmann, A Jairaman, A Sotelo, M Coburn, ...
132020
Controlled release of stem cell secretome attenuates inflammatory response against implanted biomaterials
M Mohammadi, JC Luong, SM Rodriguez, R Cao, AE Wheeler, H Lau, ...
Advanced healthcare materials 9 (12), 1901874, 2020
112020
Autologous transplantation of skin-derived precursor cells in a porcine model
AL Thomas, JS Taylor, N Huynh, G Dubrovsky, JP Chadarevian, A Chen, ...
Journal of Pediatric Surgery 55 (1), 194-200, 2020
52020
Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease
A McQuade, YJ Kang, J Hasselmann, A Jairaman, A Sotelo, M Coburn, ...
nature communications 14, 2023
42023
Novel vaccine against pathological pyroglutamate-modified amyloid beta for prevention of Alzheimer’s disease
K Zagorski, O King, A Hovakimyan, I Petrushina, T Antonyan, G Chailyan, ...
International journal of molecular sciences 24 (12), 9797, 2023
22023
CRISPR generation of CSF1R-G795A human microglia for robust microglia replacement in a chimeric mouse model
JP Chadarevian, H Davtyan, SI Lombroso, FC Bennett, M Blurton-Jones
STAR protocols 4 (3), 102490, 2023
12023
Stem-cell based biomarker discovery
M Blurton-jones, JP Chadarevian, R Spitale, S Gandhi, K Nguyen
US Patent App. 18/000,564, 2024
2024
PILRA regulates microglial neuroinflammation and lipid metabolism as a candidate therapeutic target for Alzheimer’s disease
K Monroe, T Weerakkody, H Sabelström, D Tatarakis, J Suh, M Chin, ...
2024
ER and SOCE Ca2+ signals are not required for directed cell migration in human microglia
A Granzotto, A McQuade, JP Chadarevian, H Davtyan, SL Sensi, I Parker, ...
bioRxiv, 2024.01. 18.576126, 2024
2024
Genetic modification of mammalian cells to confer resistance to csf1r antagonists
M Blurton-jones, JP Chadarevian, R Spitale, S Gandhi, W England, ...
US Patent App. 18/069,631, 2023
2023
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