Javier Santos Aberturas
Javier Santos Aberturas
Postdoctoral Researcher, John Innes Centre
Verified email at unileon.es
TitleCited byYear
PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis
N Anton, J Santos-Aberturas, MV Mendes, SM Guerra, JF Martín, ...
Microbiology 153 (9), 3174-3183, 2007
992007
Cholesterol oxidases act as signaling proteins for the biosynthesis of the polyene macrolide pimaricin
MV Mendes, E Recio, N Antón, SM Guerra, J Santos-Aberturas, JF Martín, ...
Chemistry & biology 14 (3), 279-290, 2007
672007
Functional conservation of PAS–LuxR transcriptional regulators in polyene macrolide biosynthesis
J Santos-Aberturas, TD Payero, CM Vicente, SM Guerra, C Cańibano, ...
Metabolic engineering 13 (6), 756-767, 2011
482011
Molecular control of polyene macrolide biosynthesis direct binding of the regulator PimM to eight promoters of pimaricin genes and identification of binding boxes
J Santos-Aberturas, CM Vicente, SM Guerra, TD Payero, JF Martín, ...
Journal of Biological Chemistry 286 (11), 9150-9161, 2011
482011
Structure of cytochrome P450 PimD suggests epoxidation of the polyene macrolide pimaricin occurs via a hydroperoxoferric intermediate
PM Kells, H Ouellet, J Santos-Aberturas, JF Aparicio, LM Podust
Chemistry & biology 17 (8), 841-851, 2010
452010
PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis
CM Vicente, J Santos-Aberturas, SM Guerra, TD Payero, JF Martín, ...
Microbial cell factories 8 (1), 33, 2009
432009
FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis
D Goranovič, M Blažič, V Magdevska, J Horvat, E Kuščer, T Polak, ...
BMC microbiology 12 (1), 238, 2012
392012
Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506)
C Barreiro, C Prieto, A Sola-Landa, E Solera, M Martínez-Castro, ...
Journal of bacteriology 194 (14), 3756-3757, 2012
392012
Fully automatized high‐throughput enzyme library screening using a robotic platform
M Dörr, MPC Fibinger, D Last, S Schmidt, J Santos‐Aberturas, D Böttcher, ...
Biotechnology and bioengineering 113 (7), 1421-1432, 2016
362016
Dissecting bottromycin biosynthesis using comparative untargeted metabolomics
WJK Crone, NM Vior, J Santos‐Aberturas, LG Schmitz, FJ Leeper, ...
Angewandte Chemie International Edition 55 (33), 9639-9643, 2016
322016
Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation
JF Aparicio, EG Barreales, TD Payero, CM Vicente, A de Pedro, ...
Applied microbiology and biotechnology 100 (1), 61-78, 2016
322016
LAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolor
SM Guerra, A Rodríguez-García, J Santos-Aberturas, CM Vicente, ...
PLoS One 7 (2), e31475, 2012
262012
Hierarchical control on polyene macrolide biosynthesis: PimR modulates pimaricin production via the PAS-LuxR transcriptional activator PimM
J Santos-Aberturas, CM Vicente, TD Payero, L Martín-Sánchez, ...
PLoS One 7 (6), e38536, 2012
222012
PAS-LuxR transcriptional control of filipin biosynthesis in S. avermitilis
CM Vicente, J Santos-Aberturas, TD Payero, EG Barreales, A de Pedro, ...
Applied microbiology and biotechnology 98 (22), 9311-9324, 2014
212014
In-depth high-throughput screening of protein engineering libraries by split-GFP direct crude cell extract data normalization
J Santos-Aberturas, M Dörr, GS Waldo, UT Bornscheuer
Chemistry & biology 22 (10), 1406-1414, 2015
132015
Pathway-specific regulation revisited: cross-regulation of multiple disparate gene clusters by PAS-LuxR transcriptional regulators
CM Vicente, TD Payero, J Santos-Aberturas, EG Barreales, A de Pedro, ...
Applied microbiology and biotechnology 99 (12), 5123-5135, 2015
132015
Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors
F Leipoldt, J Santos-Aberturas, DP Stegmann, F Wolf, A Kulik, R Lacret, ...
Nature communications 8 (1), 1965, 2017
122017
Macroamidine formation in bottromycins is catalyzed by a divergent YcaO enzyme
L Franz, S Adam, J Santos-Aberturas, AW Truman, J Koehnke
Journal of the American Chemical Society 139 (50), 18158-18161, 2017
102017
Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives
TD Payero, CM Vicente, Á Rumbero, EG Barreales, J Santos-Aberturas, ...
Microbial cell factories 14 (1), 114, 2015
92015
Uncovering the unexplored diversity of thioamidated ribosomal peptides in Actinobacteria using the RiPPER genome mining tool
J Santos-Aberturas, G Chandra, L Frattaruolo, R Lacret, TH Pham, ...
Nucleic acids research 47 (9), 4624-4637, 2019
62019
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