|The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes|
A Stitt, TA Gardiner, NL Anderson, P Canning, N Frizzell, N Duffy, C Boyle, ...
Diabetes 51 (9), 2826-2832, 2002
|Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling|
J Adam, E Hatipoglu, L O'Flaherty, N Ternette, N Sahgal, H Lockstone, ...
Cancer cell 20 (4), 524-537, 2011
|The role of advanced glycation end products in retinal microvascular leukostasis|
TCB Moore, JE Moore, Y Kaji, N Frizzell, T Usui, V Poulaki, IL Campbell, ...
Investigative ophthalmology & visual science 44 (10), 4457-4464, 2003
|Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status|
C Bardella, M El‐Bahrawy, N Frizzell, J Adam, N Ternette, E Hatipoglu, ...
The Journal of pathology 225 (1), 4-11, 2011
|Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant …|
YB Chen, AR Brannon, A Toubaji, ME Dudas, HH Won, HA Al-Ahmadie, ...
The American journal of surgical pathology 38 (5), 627, 2014
|S-(2-Succinyl) cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate|
NL Alderson, Y Wang, M Blatnik, N Frizzell, MD Walla, TJ Lyons, N Alt, ...
Archives of biochemistry and biophysics 450 (1), 1-8, 2006
|Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat|
NL Alderson, ME Chachich, N Frizzell, P Canning, TO Metz, ...
Diabetologia 47 (8), 1385-1395, 2004
|Succination of protein thiols during adipocyte maturation a biomarker of mitochondrial stress|
R Nagai, JW Brock, M Blatnik, JE Baatz, J Bethard, MD Walla, SR Thorpe, ...
Journal of Biological Chemistry 282 (47), 34219-34228, 2007
|Confocal Raman microscopy can quantify advanced glycation end product (AGE) modifications in Bruch’s membrane leading to accurate, nondestructive prediction of ocular aging|
JV Glenn, JR Beattie, L Barrett, N Frizzell, SR Thorpe, ME Boulton, ...
The FASEB journal 21 (13), 3542-3552, 2007
|Succination of thiol groups in adipose tissue proteins in diabetes succination inhibits polymerization and secretion of adiponectin|
N Frizzell, M Rajesh, MJ Jepson, R Nagai, JA Carson, SR Thorpe, ...
Journal of Biological Chemistry 284 (38), 25772-25781, 2009
|Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl) cysteine, a novel chemical modification of protein and possible …|
M Blatnik, N Frizzell, SR Thorpe, JW Baynes
Diabetes 57 (1), 41-49, 2008
|Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency|
N Ternette, M Yang, M Laroyia, M Kitagawa, L O’Flaherty, K Wolhulter, ...
Cell reports 3 (3), 689-700, 2013
|Fumarate hydratase–deficient renal cell carcinoma is strongly correlated with fumarate hydratase mutation and hereditary leiomyomatosis and renal cell carcinoma syndrome|
K Trpkov, O Hes, A Agaimy, M Bonert, P Martinek, C Magi-Galluzzi, ...
The American journal of surgical pathology 40 (7), 865-875, 2016
|Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor|
AW Stitt, SJ Hughes, P Canning, O Lynch, O Cox, N Frizzell, SR Thorpe, ...
Diabetologia 47 (10), 1735-1746, 2004
|The succinated proteome|
ED Merkley, TO Metz, RD Smith, JW Baynes, N Frizzell
Mass spectrometry reviews 33 (2), 98-109, 2014
|Advanced glycation and advanced lipoxidation: possible role in initiation and progression of diabetic retinopathy|
AW Stitt, N Frizzell, SR Thorpe
Current pharmaceutical design 10 (27), 3349-3360, 2004
|Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors|
AS Hoekstra, MA de Graaff, IH Briaire-de Bruijn, C Ras, RM Seifar, ...
Oncotarget 6 (36), 38777, 2015
|Morphology and immunohistochemistry for 2SC and FH aid in detection of fumarate hydratase gene aberrations in uterine leiomyomas from young patients|
NM Joseph, DA Solomon, N Frizzell, JT Rabban, C Zaloudek, K Garg
The American journal of surgical pathology 39 (11), 1529-1539, 2015
|Succination of proteins in diabetes|
N Frizzell, M Lima, JW Baynes
Free radical research 45 (1), 101-109, 2011
|Uterine smooth muscle tumors with features suggesting fumarate hydratase aberration: detailed morphologic analysis and correlation with S-(2-succino)-cysteine …|
C Reyes, Y Karamurzin, N Frizzell, K Garg, D Nonaka, YB Chen, ...
Modern Pathology 27 (7), 1020, 2014