| Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling J Adam, E Hatipoglu, L O'Flaherty, N Ternette, N Sahgal, H Lockstone, ... Cancer cell 20 (4), 524-537, 2011 | 598 | 2011 |
| The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes A Stitt, TA Gardiner, NL Anderson, P Canning, N Frizzell, N Duffy, C Boyle, ... Diabetes 51 (9), 2826-2832, 2002 | 478 | 2002 |
| Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status C Bardella, M El‐Bahrawy, N Frizzell, J Adam, N Ternette, E Hatipoglu, ... The Journal of pathology 225 (1), 4-11, 2011 | 275 | 2011 |
| The role of advanced glycation end products in retinal microvascular leukostasis TCB Moore, JE Moore, Y Kaji, N Frizzell, T Usui, V Poulaki, IL Campbell, ... Investigative ophthalmology & visual science 44 (10), 4457-4464, 2003 | 266 | 2003 |
| Hereditary leiomyomatosis and renal cell carcinoma syndrome–associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant … YB Chen, AR Brannon, A Toubaji, ME Dudas, HH Won, HA Al-Ahmadie, ... The American journal of surgical pathology 38 (5), 627-637, 2014 | 258 | 2014 |
| S-(2-Succinyl) cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate NL Alderson, Y Wang, M Blatnik, N Frizzell, MD Walla, TJ Lyons, N Alt, ... Archives of biochemistry and biophysics 450 (1), 1-8, 2006 | 213 | 2006 |
| Fumarate hydratase–deficient renal cell carcinoma is strongly correlated with fumarate hydratase mutation and hereditary leiomyomatosis and renal cell carcinoma syndrome K Trpkov, O Hes, A Agaimy, M Bonert, P Martinek, C Magi-Galluzzi, ... The American journal of surgical pathology 40 (7), 865-875, 2016 | 199 | 2016 |
| Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency N Ternette, M Yang, M Laroyia, M Kitagawa, L O’Flaherty, K Wolhulter, ... Cell reports 3 (3), 689-700, 2013 | 178 | 2013 |
| Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl) cysteine, a novel chemical modification of protein and possible … M Blatnik, N Frizzell, SR Thorpe, JW Baynes Diabetes 57 (1), 41-49, 2008 | 155 | 2008 |
| Succination of protein thiols during adipocyte maturation R Nagai, JW Brock, M Blatnik, JE Baatz, J Bethard, MD Walla, SR Thorpe, ... Journal of biological chemistry 282 (47), 34219-34228, 2007 | 149 | 2007 |
| Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat NL Alderson, ME Chachich, N Frizzell, P Canning, TO Metz, ... Diabetologia 47, 1385-1395, 2004 | 141 | 2004 |
| Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin N Frizzell, M Rajesh, MJ Jepson, R Nagai, JA Carson, SR Thorpe, ... Journal of Biological Chemistry 284 (38), 25772-25781, 2009 | 138 | 2009 |
| Confocal Raman microscopy can quantify advanced glycation end product (AGE) modifications in Bruch's membrane leading to accurate, nondestructive prediction of ocular aging JV Glenn, JR Beattie, L Barrett, N Frizzell, SR Thorpe, ME Boulton, ... The FASEB journal 21 (13), 3542-3552, 2007 | 126 | 2007 |
| Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors AS Hoekstra, MA de Graaff, IH Briaire-de Bruijn, C Ras, RM Seifar, ... Oncotarget 6 (36), 38777, 2015 | 110 | 2015 |
| Morphology and immunohistochemistry for 2SC and FH aid in detection of fumarate hydratase gene aberrations in uterine leiomyomas from young patients NM Joseph, DA Solomon, N Frizzell, JT Rabban, C Zaloudek, K Garg The American journal of surgical pathology 39 (11), 1529-1539, 2015 | 104 | 2015 |
| The succinated proteome ED Merkley, TO Metz, RD Smith, JW Baynes, N Frizzell Mass spectrometry reviews 33 (2), 98-109, 2014 | 100 | 2014 |
| Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors N Mäkinen, K Kämpjärvi, N Frizzell, R Bützow, P Vahteristo Molecular cancer 16, 1-8, 2017 | 94 | 2017 |
| Uterine smooth muscle tumors with features suggesting fumarate hydratase aberration: detailed morphologic analysis and correlation with S-(2-succino)-cysteine immunohistochemistry C Reyes, Y Karamurzin, N Frizzell, K Garg, D Nonaka, YB Chen, ... Modern Pathology 27 (7), 1020-1027, 2014 | 91 | 2014 |
| Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor AW Stitt, SJ Hughes, P Canning, O Lynch, O Cox, N Frizzell, SR Thorpe, ... Diabetologia 47, 1735-1746, 2004 | 89 | 2004 |
| A chemoproteomic portrait of the oncometabolite fumarate RA Kulkarni, DW Bak, D Wei, SE Bergholtz, CA Briney, JH Shrimp, ... Nature chemical biology 15 (4), 391-400, 2019 | 82 | 2019 |
