| Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth J Sangodkar, A Perl, R Tohme, J Kiselar, DB Kastrinsky, N Zaware, ... The Journal of clinical investigation 127 (6), 2081-2090, 2017 | 180 | 2017 |
| Therapeutic targeting of PP2A CM O’Connor, A Perl, D Leonard, J Sangodkar, G Narla The international journal of biochemistry & cell biology 96, 182-193, 2018 | 179 | 2018 |
| PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells O Kauko, CM O’Connor, E Kulesskiy, J Sangodkar, A Aakula, S Izadmehr, ... Science translational medicine 10 (450), eaaq1093, 2018 | 142 | 2018 |
| Selective PP2A enhancement through biased heterotrimer stabilization D Leonard, W Huang, S Izadmehr, CM O’Connor, DD Wiredja, Z Wang, ... Cell 181 (3), 688-701. e16, 2020 | 126 | 2020 |
| The highly recurrent PP2A Aα-subunit mutation P179R alters protein structure and impairs PP2A enzyme function to promote endometrial tumorigenesis SE Taylor, CM O'Connor, Z Wang, G Shen, H Song, D Leonard, ... Cancer research 79 (16), 4242-4257, 2019 | 45 | 2019 |
| Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors CM O’Connor, D Leonard, D Wiredja, RA Avelar, Z Wang, D Schlatzer, ... Oncogene 39 (3), 703-717, 2020 | 34 | 2020 |
| The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology studies FK Noto, J Sangodkar, BT Adedeji, S Moody, CB McClain, M Tong, ... PloS one 15 (10), e0240169, 2020 | 17 | 2020 |
| Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45) AL Perl, CM O’Connor, P Fa, FM Pozo, J Zhang, Y Zhang, G Narla Journal of Biological Chemistry 294 (45), 17043-17059, 2019 | 13 | 2019 |
| Biased holoenzyme assembly of protein phosphatase 2A (PP2A): From cancer to small molecules TJ Haanen, CM O'Connor, G Narla Journal of Biological Chemistry 298 (12), 2022 | 11 | 2022 |
| Small-molecule–mediated stabilization of PP2A modulates the homologous recombination pathway and potentiates DNA damage-induced cell death RA Avelar, AJ Armstrong, G Carvette, R Gupta, N Puleo, JA Colina, ... Molecular cancer therapeutics 22 (5), 599-615, 2023 | 9 | 2023 |
| Protein phosphatase 2A Aα regulates Aβ protein expression and stability CM O'Connor, MT Hoffa, SE Taylor, RA Avelar, G Narla Journal of Biological Chemistry 294 (15), 5923-5934, 2019 | 9 | 2019 |
| Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance R Rasool, CM O’Connor, CK Das, M Alhusayan, BK Verma, S Islam, ... Nature Communications 14 (1), 5253, 2023 | 5 | 2023 |
| PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis KD Jayappa, B Tran, VL Gordon, C Morris, S Saha, CC Farrington, ... The Journal of Clinical Investigation 133 (13), 2023 | 5 | 2023 |
| Targeting ribonucleotide reductase induces synthetic lethality in PP2A-deficient uterine serous carcinoma CM O'Connor, SE Taylor, KM Miller, L Hurst, TJ Haanen, TK Suhan, ... Cancer research 82 (4), 721-733, 2022 | 4 | 2022 |
| Splice of life for cancer: missplicing of PPP2R5A by mutant SF3B1 leads to MYC stabilization and tumorigenesis CM O'Connor, G Narla Cancer discovery 10 (6), 765-767, 2020 | 2 | 2020 |
| A Reply to'Cellular Toxicity of iHAP1 and DT-061 Does Not Occur Through PP2A-B56 Targeting' D Leonard, W Huang, DL Brautigan, A DiFeo, C O'Connor, E Ogris, ... Available at SSRN 3950751, 0 | 1 | |
| Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway A DiFeo, RA Avelar, R Gupta, G Carvette, F da Veiga Leprevost, J Colina, ... | | 2024 |
| Abstract B006: Mutant PPP2R1A induces the expression and secretion of IGFBP2 to promote uterine serous carcinoma metastasis TJ Haanen, S Boock, S Taylor, C O'Connor, A DiFeo, G Narla Clinical Cancer Research 30 (5_Supplement), B006-B006, 2024 | | 2024 |
| Synthetic lethality by targeting ribonucleotide reductase in PP2A deficient uterine serous carcinoma CM O'Connor, SE Taylor, KM Miller, L Hurst, TJ Haanen, TK Suhan, ... Cancer Research 82 (12_Supplement), 3341-3341, 2022 | | 2022 |
| Small Molecule Activators of B56-PP2A Restore 4E-BP Expression and Function to Suppress Cap-dependent Translation in Cancer Cells MA Lum, KA Jonas-Breckenridge, AR Black, NT Woods, C O’Connor, ... bioRxiv, 2022.05. 24.493272, 2022 | | 2022 |
