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Manuela Bartolini
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β-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies
M Bartolini, C Bertucci, V Cavrini, V Andrisano
Biochemical pharmacology 65 (3), 407-416, 2003
6792003
Insight Into the Kinetic of Amyloid β (1–42) Peptide Self‐Aggregation: Elucidation of Inhibitors’ Mechanism of Action
M Bartolini, C Bertucci, ML Bolognesi, A Cavalli, C Melchiorre, ...
ChemBioChem 8 (17), 2152-2161, 2007
4232007
3-(4-{[Benzyl(methyl)amino]methyl}phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) Inhibits Both Acetylcholinesterase and Acetylcholinesterase-Induced β …
L Piazzi, A Rampa, A Bisi, S Gobbi, F Belluti, A Cavalli, M Bartolini, ...
Journal of medicinal chemistry 46 (12), 2279-2282, 2003
3202003
Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer’s disease
ML Bolognesi, A Cavalli, L Valgimigli, M Bartolini, M Rosini, V Andrisano, ...
Journal of medicinal chemistry 50 (26), 6446-6449, 2007
3132007
Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds
L Piazzi, A Cavalli, F Colizzi, F Belluti, M Bartolini, F Mancini, ...
Bioorganic & Medicinal Chemistry Letters 18 (1), 423-426, 2008
2972008
Rational approach to discover multipotent anti-Alzheimer drugs
M Rosini, V Andrisano, M Bartolini, ML Bolognesi, P Hrelia, A Minarini, ...
Journal of medicinal chemistry 48 (2), 360-363, 2005
2922005
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease
P Muñoz-Ruiz, L Rubio, E García-Palomero, I Dorronsoro, ...
Journal of medicinal chemistry 48 (23), 7223-7233, 2005
2512005
Novel donepezil-based inhibitors of acetyl-and butyrylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation
P Camps, X Formosa, C Galdeano, T Gómez, D Munoz-Torrero, ...
Journal of medicinal chemistry 51 (12), 3588-3598, 2008
2432008
Inhibition of acetylcholinesterase, β-amyloid aggregation, and NMDA receptors in Alzheimer’s disease: a promising direction for the multi-target-directed ligands gold rush
M Rosini, E Simoni, M Bartolini, A Cavalli, L Ceccarini, N Pascu, ...
Journal of medicinal chemistry 51 (15), 4381-4384, 2008
2402008
A small molecule targeting the multifactorial nature of Alzheimer's disease
A Cavalli, ML Bolognesi, S Capsoni, V Andrisano, M Bartolini, E Margotti, ...
ANGEWANDTE CHEMIE. INTERNATIONAL EDITION 46, 3689-3692, 2007
2352007
Pyrano[3,2-c]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds
P Camps, X Formosa, C Galdeano, D Munoz-Torrero, L Ramirez, ...
Journal of medicinal chemistry 52 (17), 5365-5379, 2009
2312009
SAR of 9-amino-1, 2, 3, 4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues
M Recanatini, A Cavalli, F Belluti, L Piazzi, A Rampa, A Bisi, S Gobbi, ...
Journal of medicinal chemistry 43 (10), 2007-2018, 2000
2212000
Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, β amyloid aggregation, and Aβ neurotoxicity
S Rizzo, C Rivière, L Piazzi, A Bisi, S Gobbi, M Bartolini, V Andrisano, ...
Journal of medicinal chemistry 51 (10), 2883-2886, 2008
2162008
Multitarget drug design strategy: quinone–tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects
E Nepovimova, E Uliassi, J Korabecny, LE Pena-Altamira, S Samez, ...
Journal of medicinal chemistry 57 (20), 8576-8589, 2014
1892014
Tacripyrines, the first tacrine− dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer’s disease
J Marco-Contelles, R León, C De Los Ríos, A Samadi, M Bartolini, ...
Journal of medicinal chemistry 52 (9), 2724-2732, 2009
1762009
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease
ML Bolognesi, R Banzi, M Bartolini, A Cavalli, A Tarozzi, V Andrisano, ...
Journal of medicinal chemistry 50 (20), 4882-4897, 2007
1722007
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-β aggregation
ML Bolognesi, V Andrisano, M Bartolini, R Banzi, C Melchiorre
Journal of medicinal chemistry 48 (1), 24-27, 2005
1672005
Strategies for the inhibition of protein aggregation in human diseases
M Bartolini, V Andrisano
ChemBioChem 11 (8), 1018-1035, 2010
1642010
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues
ML Bolognesi, M Bartolini, A Cavalli, V Andrisano, M Rosini, A Minarini, ...
Journal of medicinal chemistry 47 (24), 5945-5952, 2004
1622004
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents
E Viayna, I Sola, M Bartolini, A De Simone, C Tapia-Rojas, FG Serrano, ...
Journal of Medicinal Chemistry 57 (6), 2549-2567, 2014
1542014
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