Martin Flajnik
Martin Flajnik
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Origin and evolution of the adaptive immune system: genetic events and selective pressures
MF Flajnik, M Kasahara
Nature Reviews Genetics 11 (1), 47-59, 2010
A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks
AS Greenberg, D Avila, M Hughes, A Hughes, EC McKinney, MF Flajnik
nature 374 (6518), 168-173, 1995
Elephant shark genome provides unique insights into gnathostome evolution
B Venkatesh, AP Lee, V Ravi, AK Maurya, MM Lian, JB Swann, Y Ohta, ...
Nature 505 (7482), 174-179, 2014
Genome evolution in the allotetraploid frog Xenopus laevis
AM Session, Y Uno, T Kwon, JA Chapman, A Toyoda, S Takahashi, ...
Nature 538 (7625), 336-343, 2016
Comparative analyses of immunoglobulin genes: surprises and portents
MF Flajnik
Nature Reviews Immunology 2 (9), 688-698, 2002
Comparative genomics of the MHC: glimpses into the evolution of the adaptive immune system
MF Flajnik, M Kasahara
Immunity 15 (3), 351-362, 2001
Evolution of innate and adaptive immunity: can we draw a line?
MF Flajnik, L Du Pasquier
Trends in immunology 25 (12), 640-644, 2004
Crystal structure of a shark single-domain antibody V region in complex with lysozyme
RL Stanfield, H Dooley, MF Flajnik, IA Wilson
Science 305 (5691), 1770-1773, 2004
The immune system of Xenopus
LD Pasquier, J Schwager, MF Flajnik
Annual review of immunology 7 (1), 251-275, 1989
The translesion DNA polymerase ζ plays a major role in Ig and bcl-6 somatic hypermutation
H Zan, A Komori, Z Li, A Cerutti, A Schaffer, MF Flajnik, M Diaz, P Casali
Immunity 14 (5), 643-653, 2001
Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins
KH Roux, AS Greenberg, L Greene, L Strelets, D Avila, EC McKinney, ...
Proceedings of the National Academy of Sciences 95 (20), 11804-11809, 1998
IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates
Y Ohta, M Flajnik
Proceedings of the National Academy of Sciences 103 (28), 10723-10728, 2006
Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display
H Dooley, MF Flajnik, AJ Porter
Molecular immunology 40 (1), 25-33, 2003
Antibody repertoire development in cartilaginous fish
H Dooley, MF Flajnik
Developmental & Comparative Immunology 30 (1-2), 43-56, 2006
Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase ζ
M Diaz, LK Verkoczy, MF Flajnik, NR Klinman
The Journal of Immunology 167 (1), 327-335, 2001
Evolutionary conservation of MHC class I and class II molecules—different yet the same
J Kaufman, J Salomonsen, M Flajnik
Seminars in immunology 6 (6), 411-424, 1994
Primitive synteny of vertebrate major histocompatibility complex class I and class II genes
Y Ohta, K Okamura, EC McKinney, S Bartl, K Hashimoto, MF Flajnik
Proceedings of the National Academy of Sciences 97 (9), 4712-4717, 2000
Evolution of the major histocompatibility complex: isolation of class II A cDNA clones from the cartilaginous fish
M Kasahara, M Vazquez, K Sato, EC McKinney, MF Flajnik
Proceedings of the National Academy of Sciences 89 (15), 6688-6692, 1992
Which came first, MHC class I or class II?
MF Flajnik, C Canel, J Kramer, M Kasahara
Immunogenetics 33 (5-6), 295-300, 1991
A case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels?
MF Flajnik, N Deschacht, S Muyldermans
PLoS Biol 9 (8), e1001120, 2011
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