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George Hedger
George Hedger
Vertex Pharmaceuticals, D. E. Shaw Research, University of Oxford
Verified email at vrtx.com
Title
Cited by
Cited by
Year
Structural basis of Smoothened regulation by its extracellular domains
EFX Byrne, R Sircar, PS Miller, G Hedger, G Luchetti, S Nachtergaele, ...
Nature 535 (7613), 517-522, 2016
3522016
PtdIns (4, 5) P 2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling
HY Yen, KK Hoi, I Liko, G Hedger, MR Horrell, W Song, D Wu, P Heine, ...
Nature 559 (7714), 423-427, 2018
2512018
Lipid interaction sites on channels, transporters and receptors: recent insights from molecular dynamics simulations
G Hedger, MSP Sansom
Biochimica et Biophysica Acta (BBA)-Biomembranes 1858 (10), 2390-2400, 2016
1682016
The juxtamembrane regions of human receptor tyrosine kinases exhibit conserved interaction sites with anionic lipids
G Hedger, MSP Sansom, H Koldsø
Scientific reports 5 (1), 9198, 2015
1132015
Convergence and sampling in determining free energy landscapes for membrane protein association
J Domański, G Hedger, RB Best, PJ Stansfeld, MSP Sansom
The journal of physical chemistry B 121 (15), 3364-3375, 2017
932017
Cholesterol interaction sites on the transmembrane domain of the hedgehog signal transducer and class FG protein-coupled receptor smoothened
G Hedger, H Koldsø, M Chavent, C Siebold, R Rohatgi, MSP Sansom
Structure 27 (3), 549-559. e2, 2019
792019
Lipid-loving ANTs: molecular simulations of cardiolipin interactions and the organization of the adenine nucleotide translocase in model mitochondrial membranes
G Hedger, SL Rouse, J Domański, M Chavent, H Koldsø, MSP Sansom
Biochemistry 55 (45), 6238-6249, 2016
612016
Free energy landscape of lipid interactions with regulatory binding sites on the transmembrane domain of the EGF receptor
G Hedger, D Shorthouse, H Koldsø, MSP Sansom
The Journal of Physical Chemistry B 120 (33), 8154-8163, 2016
562016
Lipid interactions of a ciliary membrane TRP channel: Simulation and structural studies of polycystin-2
Q Wang, RA Corey, G Hedger, P Aryal, M Grieben, C Nasrallah, ...
Structure 28 (2), 169-184. e5, 2020
382020
Interactions of the EphA2 kinase domain with PIPs in membranes: implications for receptor function
M Chavent, D Karia, AC Kalli, J Domański, AL Duncan, G Hedger, ...
Structure 26 (7), 1025-1034. e2, 2018
382018
Molecular simulations of glycolipids: Towards mammalian cell membrane models
D Shorthouse, G Hedger, H Koldsø, MSP Sansom
Biochimie 120, 105-109, 2016
352016
GPCRs: What can we learn from molecular dynamics simulations?
N Velgy, G Hedger, PC Biggin
Computational Methods for GPCR Drug Discovery, 133-158, 2018
132018
Computational Methods for GPCR Drug Discovery
A Heifetz
Humana Press, 2018
32018
A PIP2 binding site on a human TRP channel: Simulation studies of PKD2
Q Wang, G Hedger, P Aryal, J Shi, EP Carpenter, MSP Sansom
Biophysical Journal 114 (3), 397a, 2018
12018
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