| Genome-scale CRISPR-mediated control of gene repression and activation LA Gilbert, MA Horlbeck, B Adamson, JE Villalta, Y Chen, EH Whitehead, ... Cell 159 (3), 647-661, 2014 | 2860 | 2014 |
| Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation MA Horlbeck, LA Gilbert, JE Villalta, B Adamson, RA Pak, Y Chen, ... elife 5, e19760, 2016 | 772 | 2016 |
| Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway X Guo, G Aviles, Y Liu, R Tian, BA Unger, YHT Lin, AP Wiita, K Xu, ... Nature 579 (7799), 427-432, 2020 | 462 | 2020 |
| Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing JK Nuñez, J Chen, GC Pommier, JZ Cogan, JM Replogle, C Adriaens, ... Cell 184 (9), 2503-2519. e17, 2021 | 441 | 2021 |
| A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility MC Bassik, M Kampmann, RJ Lebbink, S Wang, MY Hein, I Poser, ... Cell 152 (4), 909-922, 2013 | 424 | 2013 |
| LRP1 is a master regulator of tau uptake and spread JN Rauch, G Luna, E Guzman, M Audouard, C Challis, YE Sibih, ... Nature 580 (7803), 381-385, 2020 | 423 | 2020 |
| Targeting the AAA ATPase p97 as an approach to treat cancer through disruption of protein homeostasis DJ Anderson, R Le Moigne, S Djakovic, B Kumar, J Rice, S Wong, J Wang, ... Cancer cell 28 (5), 653-665, 2015 | 400 | 2015 |
| CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons R Tian, MA Gachechiladze, CH Ludwig, MT Laurie, JY Hong, D Nathaniel, ... Neuron 104 (2), 239-255. e12, 2019 | 374 | 2019 |
| CRISPRi and CRISPRa screens in mammalian cells for precision biology and medicine M Kampmann ACS chemical biology 13 (2), 406-416, 2018 | 332 | 2018 |
| Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease K Leng, E Li, R Eser, A Piergies, R Sit, M Tan, N Neff, SH Li, ... Nature neuroscience 24 (2), 276-287, 2021 | 305 | 2021 |
| Mapping the genetic landscape of human cells MA Horlbeck, A Xu, M Wang, NK Bennett, CY Park, D Bogdanoff, ... Cell 174 (4), 953-967. e22, 2018 | 273 | 2018 |
| Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response C Sidrauski, JC Tsai, M Kampmann, BR Hearn, P Vedantham, ... elife 4, e07314, 2015 | 257 | 2015 |
| Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis R Tian, A Abarientos, J Hong, SH Hashemi, R Yan, N Dräger, K Leng, ... Nature neuroscience 24 (7), 1020-1034, 2021 | 234 | 2021 |
| Combined CRISPRi/a-based chemical genetic screens reveal that rigosertib is a microtubule-destabilizing agent M Jost, Y Chen, LA Gilbert, MA Horlbeck, L Krenning, G Menchon, A Rai, ... Molecular cell 68 (1), 210-223. e6, 2017 | 231 | 2017 |
| Probing the global cellular responses to lipotoxicity caused by saturated fatty acids M Piccolis, LM Bond, M Kampmann, P Pulimeno, C Chitraju, CBK Jayson, ... Molecular cell 74 (1), 32-44. e8, 2019 | 222 | 2019 |
| Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity YJ Zhang, L Guo, PK Gonzales, TF Gendron, Y Wu, K Jansen-West, ... Science 363 (6428), eaav2606, 2019 | 220 | 2019 |
| The mTOR complex controls HIV latency E Besnard, S Hakre, M Kampmann, HW Lim, NN Hosmane, A Martin, ... Cell host & microbe 20 (6), 785-797, 2016 | 217 | 2016 |
| Tau internalization is regulated by 6-O sulfation on heparan sulfate proteoglycans (HSPGs) JN Rauch, JJ Chen, AW Sorum, GM Miller, T Sharf, SK See, ... Scientific reports 8 (1), 6382, 2018 | 183 | 2018 |
| Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification RM Deans, DW Morgens, A Ökesli, S Pillay, MA Horlbeck, M Kampmann, ... Nature chemical biology 12 (5), 361-366, 2016 | 178 | 2016 |
| Dual gene activation and knockout screen reveals directional dependencies in genetic networks M Boettcher, R Tian, JA Blau, E Markegard, RT Wagner, D Wu, X Mo, ... Nature biotechnology 36 (2), 170-178, 2018 | 154 | 2018 |
