Type IIA topoisomerase inhibition by a new class of antibacterial agents BD Bax, PF Chan, DS Eggleston, A Fosberry, DR Gentry, F Gorrec, ... Nature 466 (7309), 935-940, 2010 | 823 | 2010 |
Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance A Wohlkonig, PF Chan, AP Fosberry, P Homes, J Huang, M Kranz, ... Nature structural & molecular biology 17 (9), 1152-1153, 2010 | 335 | 2010 |
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling KE McNally, R Faulkner, F Steinberg, M Gallon, R Ghai, D Pim, P Langton, ... Nature cell biology 19 (10), 1214-1225, 2017 | 276 | 2017 |
RNA as a drug target ND Pearson, CD Prescott Chemistry & biology 4 (6), 409-414, 1997 | 107 | 1997 |
Asymmetric rhodium carbenoid insertion into the Si H bond RT Buck, MP Doyle, MJ Drysdale, L Ferris, DC Forbes, D Haigh, ... Tetrahedron letters 37 (42), 7631-7634, 1996 | 94 | 1996 |
N–H insertion reactions of rhodium carbenoids. Part 1. Preparation of α-amino acid and α-aminophosphonic acid derivatives J BobbyáSanghera Journal of the Chemical Society, Perkin Transactions 1, 2879-2884, 1996 | 88 | 1996 |
β-, γ-and δ-Lactams as conformational constraints in ring-closing metathesis CA Tarling, AB Holmes, RE Markwell, ND Pearson Journal of the Chemical Society, Perkin Transactions 1, 1695-1702, 1999 | 73 | 1999 |
Novel hydroxyl tricyclics (eg, GSK966587) as potent inhibitors of bacterial type IIA topoisomerases TJ Miles, AJ Hennessy, B Bax, G Brooks, BS Brown, P Brown, N Cailleau, ... Bioorganic & medicinal chemistry letters 23 (19), 5437-5441, 2013 | 65 | 2013 |
Penem inhibitors of bacterial signal peptidase AE Allsop, G Brooks, G Bruton, S Coulton, PD Edwards, IK Hatton, ... Bioorganic & Medicinal Chemistry Letters 5 (5), 443-448, 1995 | 65 | 1995 |
Asymmetric rhodium carbene insertion into the Si H bond: identification of new dirhodium (II) carboxylate catalysts using parallel synthesis techniques RT Buck, DM Coe, MJ Drysdale, L Ferris, D Haigh, CJ Moody, ... Tetrahedron: Asymmetry 14 (7), 791-816, 2003 | 57 | 2003 |
The carbenoid approach to peptide synthesis RT Buck, PA Clarke, DM Coe, MJ Drysdale, L Ferris, D Haigh, CJ Moody, ... Chemistry–A European Journal 6 (12), 2160-2167, 2000 | 55 | 2000 |
Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases TJ Miles, C Barfoot, G Brooks, P Brown, D Chen, S Dabbs, DT Davies, ... Bioorganic & medicinal chemistry letters 21 (24), 7483-7488, 2011 | 54 | 2011 |
Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases TJ Miles, JM Axten, C Barfoot, G Brooks, P Brown, D Chen, S Dabbs, ... Bioorganic & medicinal chemistry letters 21 (24), 7489-7495, 2011 | 53 | 2011 |
Novel tricyclics (eg, GSK945237) as potent inhibitors of bacterial type IIA topoisomerases TJ Miles, AJ Hennessy, B Bax, G Brooks, BS Brown, P Brown, N Cailleau, ... Bioorganic & medicinal chemistry letters 26 (10), 2464-2469, 2016 | 48 | 2016 |
Developing dental services for homeless people in East London D Simons, N Pearson, Z Movasaghi British Dental Journal 213 (7), E11-E11, 2012 | 44 | 2012 |
Quinolines and nitrogenated derivative thereof substituted in 4-position by a piperidine-containing moiety and their use as antibacterial agents DT Davies, GE Jones, RE Markwell, W Miller, ND Pearson US Patent 7,205,408, 2007 | 44 | 2007 |
Dental service use and the implications for oral cancer screening in a sample of Bangladeshi adult medical care users living in Tower Hamlets, UK N Pearson, R Croucher, W Marcenes, M O'Farrell British Dental Journal 186 (10), 517-521, 1999 | 38 | 1999 |
Parallel synthesis techniques in the identification of new chiral dirhodium (II) carboxylates for asymmetric carbenoid insertion reactions RT Buck, DM Coe, MJ Drysdale, CJ Moody, ND Pearson Tetrahedron letters 39 (39), 7181-7184, 1998 | 38 | 1998 |
Compounds JM Axten, RA Daines, DT Davies, TF Gallagher, GE Jones, WH Miller, ... US Patent 7,498,326, 2009 | 37 | 2009 |
Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity DT Davies, GE Jones, AP Lightfoot, RE Markwell, ND Pearson US Patent 6,962,917, 2005 | 37 | 2005 |