The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans YM Loo, PM McTamney, RH Arends, ME Abram, AA Aksyuk, S Diallo, ... Science translational medicine 14 (635), eabl8124, 2022 | 174 | 2022 |
Surface acoustic wave nebulization produces ions with lower internal energy than electrospray ionization Y Huang, SH Yoon, SR Heron, CD Masselon, JS Edgar, F Tureček, ... Journal of the American Society for Mass Spectrometry 23 (6), 1062-1070, 2012 | 76 | 2012 |
Surface acoustic wave nebulization facilitating lipid mass spectrometric analysis SH Yoon, Y Huang, JS Edgar, YS Ting, SR Heron, Y Kao, Y Li, ... Analytical chemistry 84 (15), 6530-6537, 2012 | 70 | 2012 |
AZD7442 demonstrates prophylactic and therapeutic efficacy in non-human primates and extended half-life in humans YM Loo, PM McTamney, RH Arends, RA Gasser Jr, ME Abram, A Aksyuk, ... Medrxiv, 2021.08. 30.21262666, 2021 | 35 | 2021 |
Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease S Pechenov, J Revell, S Will, J Naylor, P Tyagi, C Patel, L Liang, L Tseng, ... Scientific reports 11 (1), 22521, 2021 | 33 | 2021 |
ADME considerations and bioanalytical strategies for pharmacokinetic assessments of antibody-drug conjugates S Mou, Y Huang, AI Rosenbaum Antibodies 7 (4), 41, 2018 | 31 | 2018 |
Rapid lipid a structure determination via surface acoustic wave nebulization and hierarchical tandem mass spectrometry algorithm SH Yoon, T Liang, T Schneider, BL Oyler, CE Chandler, RK Ernst, GS Yen, ... Rapid Communications in Mass Spectrometry 30 (23), 2555-2560, 2016 | 26 | 2016 |
Characterization of Antibody–Drug Conjugate Pharmacokinetics and in Vivo Biotransformation Using Quantitative Intact LC-HRMS and Surrogate Analyte LC-MRM Y Huang, S Mou, Y Wang, R Mu, M Liang, AI Rosenbaum Analytical Chemistry 93 (15), 6135-6144, 2021 | 23 | 2021 |
Surface acoustic wave nebulization device with dual interdigitated transducers improves SAWN‐MS performance Y Huang, SR Heron, AM Clark, JS Edgar, SH Yoon, DPA Kilgour, ... Journal of Mass Spectrometry 51 (6), 424-429, 2016 | 23 | 2016 |
Design and preclinical evaluation of a novel B7-H4–directed antibody–drug conjugate, AZD8205, alone and in combination with the PARP1-selective inhibitor AZD5305 K Kinneer, P Wortmann, ZA Cooper, NJ Dickinson, L Masterson, ... Clinical Cancer Research 29 (6), 1086-1101, 2023 | 20 | 2023 |
AZD7442 demonstrates prophylactic and therapeutic efficacy in non-human primates and extended half-life in humans (preprint) YM Loo, PM McTamney, RH Arends, RA Gasser Jr, ME Abram, A Aksyuk, ... | 20 | 2021 |
Targeted oral peptide delivery using multi-unit particulates: Drug and permeation enhancer layering approach P Tyagi, R Trivedi, S Pechenov, C Patel, J Revell, S Wills, Y Huang, ... Journal of Controlled Release 338, 784-791, 2021 | 17 | 2021 |
Multifaceted bioanalytical methods for the comprehensive pharmacokinetic and catabolic assessment of MEDI3726, an anti-prostate-specific membrane antigen pyrrolobenzodiazepine … Y Huang, CJ Del Nagro, K Balic, WR Mylott Jr, OA Ismaiel, E Ma, M Faria, ... Analytical Chemistry 92 (16), 11135-11144, 2020 | 17 | 2020 |
Optimized surface acoustic wave nebulization facilitates bacterial phenotyping T Liang, T Schneider, SH Yoon, BL Oyler, LM Leung, WE Fondrie, G Yen, ... International Journal of Mass Spectrometry 427, 65-72, 2018 | 17 | 2018 |
Bioanalytical methods and strategic perspectives addressing the rising complexity of novel bioconjugates and delivery routes for biotherapeutics R Mu, J Yuan, Y Huang, JK Meissen, S Mou, M Liang, AI Rosenbaum BioDrugs 36 (2), 181-196, 2022 | 12 | 2022 |
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans. Sci. Transl. Med. 14, eabl8124 YM Loo, PM McTamney, RH Arends, ME Abram, AA Aksyuk, S Diallo, ... | 10 | 2022 |
Multiplex hybrid antigen-capture LC-MRM quantification in sera and nasal lining fluid of AZD7442, a SARS-CoV-2-targeting antibody combination R Mu, Y Huang, J Bouquet, J Yuan, RJ Kubiak, E Ma, S Naser, ... Analytical Chemistry 94 (43), 14835-14845, 2022 | 9 | 2022 |
Polydimethylsiloxane microchannel coupled to surface acoustic wave nebulization mass spectrometry. GS Yen, JS Edgar, SH Yoon, Y Huang, SR Heron, DT Chiu, DR Goodlett Rapid Communications in Mass Spectrometry: RCM 30 (8), 2016 | 8 | 2016 |
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans. Sci Transl Med. 2022; 14 (635): eabl8124 YM Loo, PM McTamney, RH Arends, ME Abram, AA Aksyuk, S Diallo | 8 | |
AZD9592: an EGFR-cMET bispecific antibody-drug conjugate (ADC) targeting key oncogenic drivers in non-small-cell lung cancer (NSCLC) and beyond F Comer, Y Mazor, E Hurt, C Yang, R Fleming, H Shandilya, ... Cancer Research 83 (7_Supplement), 5736-5736, 2023 | 5 | 2023 |