| Protein–DNA binding: complexities and multi-protein codes T Siggers, R Gordân Nucleic acids research 42 (4), 2099-2111, 2014 | 262 | 2014 |
| Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding T Siggers, AB Chang, A Teixeira, D Wong, KJ Williams, B Ahmed, ... Nature immunology 13 (1), 95-102, 2012 | 250 | 2012 |
| Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs L Giorgetti, T Siggers, G Tiana, G Caprara, S Notarbartolo, T Corona, ... Molecular cell 37 (3), 418-428, 2010 | 201 | 2010 |
| Extensive characterization of NF-κB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits D Wong, A Teixeira, S Oikonomopoulos, P Humburg, IN Lone, D Saliba, ... Genome biology 12, 1-19, 2011 | 188 | 2011 |
| Survey of variation in human transcription factors reveals prevalent DNA binding changes LA Barrera, A Vedenko, JV Kurland, JM Rogers, SS Gisselbrecht, ... Science 351 (6280), 1450-1454, 2016 | 181 | 2016 |
| Non‐DNA‐binding cofactors enhance DNA‐binding specificity of a transcriptional regulatory complex T Siggers, MH Duyzend, J Reddy, S Khan, ML Bulyk Molecular systems biology 7 (1), 555, 2011 | 136 | 2011 |
| Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity S Rowan, T Siggers, SA Lachke, Y Yue, ML Bulyk, RL Maas Genes & development 24 (10), 980-985, 2010 | 125 | 2010 |
| The CLAMP protein links the MSL complex to the X chromosome during Drosophila dosage compensation MML Soruco, J Chery, EP Bishop, T Siggers, MY Tolstorukov, AR Leydon, ... Genes & development 27 (14), 1551-1556, 2013 | 122 | 2013 |
| Structural alignment of protein–DNA interfaces: insights into the determinants of binding specificity TW Siggers, A Silkov, B Honig Journal of molecular biology 345 (5), 1027-1045, 2005 | 82 | 2005 |
| Transcription factor NF-κB is modulated by symbiotic status in a sea anemone model of cnidarian bleaching KM Mansfield, NM Carter, L Nguyen, PA Cleves, A Alshanbayeva, ... Scientific reports 7 (1), 16025, 2017 | 80 | 2017 |
| DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation KK Andrilenas, V Ramlall, J Kurland, B Leung, AG Harbaugh, T Siggers Nucleic acids research 46 (5), 2509-2520, 2018 | 76 | 2018 |
| Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity A Penvose, JL Keenan, D Bray, V Ramlall, T Siggers Nature communications 10 (1), 2514, 2019 | 75 | 2019 |
| Structure-based prediction of C2H2 zinc-finger binding specificity: sensitivity to docking geometry TW Siggers, B Honig Nucleic acids research 35 (4), 1085-1097, 2007 | 70 | 2007 |
| Diversification of transcription factor paralogs via noncanonical modularity in C2H2 zinc finger DNA binding T Siggers, J Reddy, B Barron, ML Bulyk Molecular cell 55 (4), 640-648, 2014 | 63 | 2014 |
| DNA-binding and-bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides KM Viiri, J Jänis, T Siggers, TYK Heinonen, J Valjakka, ML Bulyk, ... Molecular and cellular biology 29 (2), 342-356, 2009 | 61 | 2009 |
| Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation G Kuzu, EG Kaye, J Chery, T Siggers, L Yang, JR Dobson, S Boor, J Bliss, ... PLoS genetics 12 (7), e1006120, 2016 | 47 | 2016 |
| NextPBM: a platform to study cell-specific transcription factor binding and cooperativity N Mohaghegh, D Bray, J Keenan, A Penvose, KK Andrilenas, V Ramlall, ... Nucleic acids research 47 (6), e31-e31, 2019 | 36 | 2019 |
| Using protein-binding microarrays to study transcription factor specificity: homologs, isoforms and complexes KK Andrilenas, A Penvose, T Siggers Briefings in functional genomics 14 (1), 17-29, 2015 | 32 | 2015 |
| Grhl2 is required in nonneural tissues for neural progenitor survival and forebrain development C Menke, M Cionni, T Siggers, ML Bulyk, DR Beier, RW Stottmann genesis 53 (9), 573-582, 2015 | 22 | 2015 |
| Transcription factor NF-κB in a basal metazoan, the sponge, has conserved and unique sequences, activities, and regulation LM Williams, MM Inge, KM Mansfield, A Rasmussen, J Afghani, M Agrba, ... Developmental & Comparative Immunology 104, 103559, 2020 | 16 | 2020 |
Thomas GilmoreProfessor of Biology, Boston UniversityVerified email at bu.edu
