| Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases DH Kwan, Y Sun, F Schulz, H Hong, B Popovic, JCC Sim-Stark, ... Chemistry & biology 15 (11), 1231-1240, 2008 | 158 | 2008 |
| The stereochemistry of complex polyketide biosynthesis by modular polyketide synthases DH Kwan, F Schulz Molecules 16 (7), 6092-6115, 2011 | 101 | 2011 |
| Self‐immobilizing fluorogenic imaging agents of enzyme activity DH Kwan, HM Chen, K Ratananikom, SM Hancock, Y Watanabe, ... Angewandte Chemie 1 (123), 314-317, 2010 | 92 | 2010 |
| Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation G Volkers, LJ Worrall, DH Kwan, CC Yu, L Baumann, E Lameignere, ... Nature structural & molecular biology 22 (8), 627-635, 2015 | 73 | 2015 |
| Enhancement of biological reactions on cell surfaces via macromolecular crowding R Chapanian, DH Kwan, I Constantinescu, FA Shaikh, NAA Rossi, ... Nature communications 5 (1), 4683, 2014 | 66 | 2014 |
| Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity DH Kwan, PF Leadlay ACS chemical biology 5 (9), 829-838, 2010 | 64 | 2010 |
| Toward efficient enzymes for the generation of universal blood through structure-guided directed evolution DH Kwan, I Constantinescu, R Chapanian, MA Higgins, MP Kötzler, ... Journal of the American Chemical Society 137 (17), 5695-5705, 2015 | 58 | 2015 |
| Insights into the stereospecificity of ketoreduction in a modular polyketide synthase DH Kwan, M Tosin, N Schläger, F Schulz, PF Leadlay Organic & biomolecular chemistry 9 (7), 2053-2056, 2011 | 45 | 2011 |
| Facile formation of β‐thioGlcNAc linkages to thiol‐containing sugars, peptides, and proteins using a mutant GH20 hexosaminidase G Tegl, J Hanson, HM Chen, DH Kwan, AG Santana, SG Withers Angewandte Chemie International Edition 58 (6), 1632-1637, 2019 | 43 | 2019 |
| A high-throughput glycosyltransferase inhibition assay for identifying molecules targeting fucosylation in cancer cell-surface modification X Zhang, F Chen, A Petrella, F Chacon-Huete, J Covone, TW Tsai, CC Yu, ... ACS Chemical Biology 14 (4), 715-724, 2019 | 26 | 2019 |
| Chemoenzymatic synthesis of a type 2 blood group A tetrasaccharide and development of high-throughput assays enables a platform for screening blood group antigen-cleaving enzymes DH Kwan, S Ernst, MP Kötzler, SG Withers Glycobiology 25 (8), 806-811, 2015 | 19 | 2015 |
| A plate-based high-throughput activity assay for polysialyltransferase from Neisseria meningitidis CC Yu, T Hill, DH Kwan, HM Chen, CC Lin, W Wakarchuk, SG Withers Analytical biochemistry 444, 67-74, 2014 | 18 | 2014 |
| A glyco-gold nanoparticle based assay for α-2, 8-polysialyltransferase from Neisseria meningitidis CC Yu, LD Huang, DH Kwan, WW Wakarchuk, SG Withers, CC Lin Chemical communications 49 (86), 10166-10168, 2013 | 16 | 2013 |
| Toward efficient enzymatic glycan synthesis: directed evolution and enzyme engineering DH Kwan, SG Withers Journal of Carbohydrate Chemistry 30 (4-6), 181-205, 2011 | 14 | 2011 |
| Resources and methods for engineering “designer” glycan-binding proteins R Warkentin, DH Kwan Molecules 26 (2), 380, 2021 | 13 | 2021 |
| A fucosyltransferase inhibition assay using image-analysis and digital microfluidics LMY Leclerc, G Soffer, DH Kwan, SCC Shih Biomicrofluidics 13 (3), 2019 | 13 | 2019 |
| A versatile transcription factor biosensor system responsive to multiple aromatic and indole inducers MA Nasr, LR Timmins, VJJ Martin, DH Kwan ACS Synthetic Biology 11 (4), 1692-1698, 2022 | 12 | 2022 |
| Chemoenzymatic synthesis of 6‐phospho‐cyclophellitol as a novel probe of 6‐phospho‐β‐glucosidases DH Kwan, Y Jin, J Jiang, HM Chen, MP Kötzler, HS Overkleeft, GJ Davies, ... FEBS letters 590 (4), 461-468, 2016 | 12 | 2016 |
| Structure-guided directed evolution of glycosidases: A case study in engineering a blood group antigen-cleaving enzyme DH Kwan Methods in enzymology 597, 25-53, 2017 | 5 | 2017 |
| Divergent directed evolution of a TetR-type repressor towards aromatic molecules MA Nasr, VJJ Martin, DH Kwan Nucleic Acids Research 51 (14), 7675-7690, 2023 | 4 | 2023 |
Steve WithersProfessor of Chemistry and Biochemistry, University Of British ColumbiaVerified email at chem.ubc.ca
