Ruud van der Breggen
Ruud van der Breggen
LUMC Leiden
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Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
J Deelen, M Beekman, HW Uh, Q Helmer, M Kuningas, L Christiansen, ...
Aging cell 10 (4), 686-698, 2011
A genome‐wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22
HJM Kerkhof, RJ Lories, I Meulenbelt, I Jonsdottir, AM Valdes, P Arp, ...
Arthritis & Rheumatism: Official Journal of the American College of …, 2010
Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis
I Meulenbelt, JL Min, S Bos, N Riyazi, JJ Houwing-Duistermaat, ...
Human molecular genetics 17 (12), 1867-1875, 2008
Disease variants alter transcription factor levels and methylation of their binding sites
MJ Bonder, R Luijk, DV Zhernakova, M Moed, P Deelen, M Vermaat, ...
Nature genetics 49 (1), 131, 2017
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
J Deelen, M Beekman, HW Uh, L Broer, KL Ayers, Q Tan, Y Kamatani, ...
Human molecular genetics 23 (16), 4420-4432, 2014
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array
RC Slieker, SD Bos, JJ Goeman, JVMG Bovée, RP Talens, ...
Epigenetics & chromatin 6 (1), 26, 2013
A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5′ UTR of GDF5 with osteoarthritis susceptibility
K Chapman, A Takahashi, I Meulenbelt, C Watson, J Rodriguez-Lopez, ...
Human molecular genetics 17 (10), 1497-1504, 2008
Genetic and environmental influences interact with age and sex in shaping the human methylome
J Van Dongen, MG Nivard, G Willemsen, JJ Hottenga, Q Helmer, ...
Nature communications 7, 11115, 2016
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity
M Beekman, C Nederstigt, HED Suchiman, D Kremer, R van der Breggen, ...
Proceedings of the National Academy of Sciences 107 (42), 18046-18049, 2010
Gene expression analysis of mTOR pathway: association with human longevity
WM Passtoors, M Beekman, J Deelen, R van der Breggen, AB Maier, ...
Aging Cell 12 (1), 24-31, 2013
Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study
YFM Ramos, W den Hollander, JVMG Bovée, N Bomer, ...
PloS one 9 (7), e103056, 2014
Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches
W Den Hollander, YFM Ramos, SD Bos, N Bomer, R van der Breggen, ...
Annals of the rheumatic diseases 73 (12), 2208-2212, 2014
Improving phenotypic prediction by combining genetic and epigenetic associations
S Shah, MJ Bonder, RE Marioni, Z Zhu, AF McRae, A Zhernakova, ...
The American Journal of Human Genetics 97 (1), 75-85, 2015
Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues
SD Bos, JVMG Bovée, BJ Duijnisveld, EVA Raine, WJ van Dalen, ...
Annals of the rheumatic diseases 71 (7), 1254-1258, 2012
Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis
N Bomer, W den Hollander, YFM Ramos, SD Bos, R van der Breggen, ...
Annals of the rheumatic diseases 74 (8), 1571-1579, 2015
Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations
I Meulenbelt, K Chapman, R Dieguez-Gonzalez, D Shi, A Tsezou, J Dai, ...
Human molecular genetics 18 (8), 1518-1523, 2009
Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility
I Meulenbelt, SD Bos, K Chapman, R van der Breggen, ...
Annals of the rheumatic diseases 70 (1), 164-167, 2011
Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R
WM Passtoors, JM Boer, JJ Goeman, EB van den Akker, J Deelen, ...
PLoS one 7 (1), e27759, 2012
Transcriptional associations of osteoarthritis‐mediated loss of epigenetic control in articular cartilage
W den Hollander, YFM Ramos, N Bomer, S Elzinga, R van der Breggen, ...
Arthritis & rheumatology 67 (8), 2108-2116, 2015
Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs
I Ricaño-Ponce, DV Zhernakova, P Deelen, O Luo, X Li, A Isaacs, ...
Journal of autoimmunity 68, 62-74, 2016
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