Nathan Rose
Nathan Rose
Head of Regulatory Science, Oxitec
Verified email at oxitec.com - Homepage
TitleCited byYear
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
R Chowdhury, KK Yeoh, YM Tian, L Hillringhaus, EA Bagg, NR Rose, ...
EMBO reports 12 (5), 463-469, 2011
6602011
Understanding the relationship between DNA methylation and histone lysine methylation
NR Rose, RJ Klose
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1839 (12 …, 2014
3062014
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
AM Farcas, NP Blackledge, I Sudbery, HK Long, JF McGouran, NR Rose, ...
Elife 1, e00205, 2012
2882012
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
SS Ng, KL Kavanagh, MA McDonough, D Butler, ES Pilka, BMR Lienard, ...
Nature 448 (7149), 87-91, 2007
2852007
Inhibition of 2-oxoglutarate dependent oxygenases
NR Rose, MA McDonough, ONF King, A Kawamura, CJ Schofield
Chemical Society Reviews 40 (8), 4364-4397, 2011
2622011
Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases⊥
NR Rose, SS Ng, J Mecinović, BMR Liénard, SH Bello, Z Sun, ...
Journal of medicinal chemistry 51 (22), 7053-7056, 2008
1932008
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors
ONF King, XS Li, M Sakurai, A Kawamura, NR Rose, SS Ng, AM Quinn, ...
PloS one 5 (11), e15535, 2010
1852010
Targeting Polycomb systems to regulate gene expression: modifications to a complex story
Neil P Blackledge, Nathan R Rose, Robert J Klose
Nature Reviews Molecular Cell Biology, 2015
1592015
Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches
NR Rose, ECY Woon, GL Kingham, ONF King, J Mecinovic, IJ Clifton, ...
Journal of medicinal chemistry 53 (4), 1810-1818, 2010
1472010
Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post‐Translational Modifications
JM Chalker, L Lercher, NR Rose, CJ Schofield, BG Davis
Angewandte Chemie International Edition 51 (8), 1835-1839, 2012
1402012
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nε-dimethyl lysine demethylase
C Loenarz, W Ge, ML Coleman, NR Rose, CDO Cooper, RJ Klose, ...
Human molecular genetics 19 (2), 217-222, 2010
1402010
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family
L Hillringhaus, WW Yue, NR Rose, SS Ng, C Gileadi, C Loenarz, SH Bello, ...
Journal of Biological Chemistry 286 (48), 41616-41625, 2011
1032011
5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation
RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ...
Chem. Sci., 2013
992013
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases
NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ...
Journal of Medicinal Chemistry 55 (14), 6639-6643, 2012
942012
Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases
R Chowdhury, JI Candela-Lena, MC Chan, DJ Greenald, KK Yeoh, ...
ACS chemical biology, 2013
832013
Inhibition of Histone Demethylases by 4‐Carboxy‐2, 2′‐Bipyridyl Compounds
KH Chang, ONF King, A Tumber, ECY Woon, TD Heightman, ...
ChemMedChem 6 (5), 759-764, 2011
782011
A miniaturized screen for inhibitors of Jumonji histone demethylases
M Sakurai, NR Rose, L Schultz, AM Quinn, A Jadhav, SS Ng, ...
Molecular BioSystems 6 (2), 357-364, 2010
782010
Development of homogeneous luminescence assays for histone demethylase catalysis and binding
A Kawamura, A Tumber, NR Rose, ONF King, M Daniel, U Oppermann, ...
Analytical biochemistry 404 (1), 86-93, 2010
692010
Linking of 2‐Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases
ECY Woon, A Tumber, A Kawamura, L Hillringhaus, W Ge, NR Rose, ...
Angewandte Chemie International Edition 51 (7), 1631-1634, 2012
612012
Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II)
R Sekirnik, NR Rose, A Thalhammer, PT Seden, J Mecinović, ...
Chem Commun, 6376-6378, 2009
602009
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