| Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia MA Dawson, RK Prinjha, A Dittmann, G Giotopoulos, M Bantscheff, ... Nature 478 (7370), 529-533, 2011 | 1748 | 2011 |
| Suppression of inflammation by a synthetic histone mimic E Nicodeme, KL Jeffrey, U Schaefer, S Beinke, S Dewell, C Chung, ... Nature 468 (7327), 1119-1123, 2010 | 1740 | 2010 |
| Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways JP Cogswell, J Ward, IA Taylor, M Waters, Y Shi, B Cannon, K Kelnar, ... Journal of Alzheimer's disease 14 (1), 27-41, 2008 | 1116 | 2008 |
| Inhibitor of neurite outgrowth in humans WFS Prinjha R, Moore SE, Vinson M, Blake S, Morrow R, Christie G ... Nature 403, 383-4, 2000 | 884 | 2000 |
| Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription MU Kaikkonen, NJ Spann, S Heinz, CE Romanoski, KA Allison, ... Molecular cell 51 (3), 310-325, 2013 | 726 | 2013 |
| Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation HD Lewis, J Liddle, JE Coote, SJ Atkinson, MD Barker, BD Bax, KL Bicker, ... Nature chemical biology 11 (3), 189-191, 2015 | 720 | 2015 |
| Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease H Li, S Wetten, L Li, PLS Jean, R Upmanyu, L Surh, D Hosford, ... Archives of neurology 65 (1), 45-53, 2008 | 599 | 2008 |
| Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis SE Baranzini, J Wang, RA Gibson, N Galwey, Y Naegelin, F Barkhof, ... Human molecular genetics 18 (4), 767-778, 2009 | 587 | 2009 |
| BET inhibitor resistance emerges from leukaemia stem cells CY Fong, O Gilan, EYN Lam, AF Rubin, S Ftouni, D Tyler, K Stanley, ... Nature 525 (7570), 538-542, 2015 | 537 | 2015 |
| An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer ML Burr, CE Sparbier, KL Chan, YC Chan, A Kersbergen, EYN Lam, ... Cancer cell 36 (4), 385-401. e8, 2019 | 529 | 2019 |
| Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins RJ Giger, JF Cloutier, A Sahay, RK Prinjha, DV Levengood, SE Moore, ... Neuron 25 (1), 29-41, 2000 | 518 | 2000 |
| Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice A Halper-Stromberg, CL Lu, F Klein, JA Horwitz, S Bournazos, L Nogueira, ... Cell 158 (5), 989-999, 2014 | 437 | 2014 |
| Discovery and characterization of small molecule inhibitors of the BET family bromodomains C Chung, H Coste, JH White, O Mirguet, J Wilde, RL Gosmini, C Delves, ... Journal of medicinal chemistry 54 (11), 3827-3838, 2011 | 432 | 2011 |
| Cloning and functional expression of a human orthologue of rat vanilloid receptor-1 P Hayes, HJ Meadows, MJ Gunthorpe, MH Harries, MD Duckworth, ... Pain 88 (2), 205-215, 2000 | 402 | 2000 |
| Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia P Ntziachristos, A Tsirigos, GG Welstead, T Trimarchi, S Bakogianni, L Xu, ... Nature 514 (7523), 513-517, 2014 | 396 | 2014 |
| Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains O Mirguet, R Gosmini, J Toum, CA Clément, M Barnathan, JM Brusq, ... Journal of medicinal chemistry 56 (19), 7501-7515, 2013 | 355 | 2013 |
| Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation O Gilan, I Rioja, K Knezevic, MJ Bell, MM Yeung, NR Harker, EYN Lam, ... Science 368 (6489), 387-394, 2020 | 347 | 2020 |
| Suppression of the antiviral response by an influenza histone mimic I Marazzi, JSY Ho, J Kim, B Manicassamy, S Dewell, RA Albrecht, ... Nature 483 (7390), 428-433, 2012 | 340 | 2012 |
| Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling D Levy, AJ Kuo, Y Chang, U Schaefer, C Kitson, P Cheung, A Espejo, ... Nature immunology 12 (1), 29, 2011 | 298 | 2011 |
| Place your BETs: the therapeutic potential of bromodomains RK Prinjha, J Witherington, K Lee Trends in pharmacological sciences 33 (3), 146-153, 2012 | 278 | 2012 |
David ToughGSKVerified email at gsk.com
