| AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo … BR Davies, A Logie, JS McKay, P Martin, S Steele, R Jenkins, M Cockerill, ... Molecular cancer therapeutics 6 (8), 2209-2219, 2007 | 501 | 2007 |
| Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244) JR Dry, S Pavey, CA Pratilas, C Harbron, S Runswick, D Hodgson, ... Cancer research, 0008-5472. CAN-09-1577, 2010 | 264 | 2010 |
| Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia MB Pappalardi, K Keenan, M Cockerill, WA Kellner, A Stowell, C Sherk, ... Nature cancer 2 (10), 1002-1017, 2021 | 115 | 2021 |
| Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments JR Hitchin, J Blagg, R Burke, S Burns, MJ Cockerill, EE Fairweather, ... MedChemComm 4 (11), 1513-1522, 2013 | 79 | 2013 |
| CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1 JT Lynch, MJ Cockerill, JR Hitchin, DH Wiseman, TCP Somervaille Analytical biochemistry 442 (1), 104-106, 2013 | 62 | 2013 |
| Genomics and the search for novel biomarkers in toxicology JD Tugwood, LE Hollins, MJ Cockerill Biomarkers 8 (2), 79-92, 2003 | 59 | 2003 |
| Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells S Jones, J Ahmet, K Ayton, M Ball, M Cockerill, E Fairweather, N Hamilton, ... Journal of medicinal chemistry 59 (24), 11120-11137, 2016 | 52 | 2016 |
| In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor AG Gilmartin, A Groy, ER Gore, C Atkins, ER Long, MN Montoute, Z Wu, ... Haematologica 106 (7), 1979, 2021 | 41 | 2021 |
| Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis JG Kettle, P Ballard, C Bardelle, M Cockerill, N Colclough, SE Critchlow, ... Journal of medicinal chemistry 58 (6), 2834-2844, 2015 | 29 | 2015 |
| Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome AL Ashford, TPJ Dunkley, M Cockerill, RA Rowlinson, LM Baak, R Gallo, ... Cellular and molecular life sciences 73 (4), 883-900, 2016 | 27 | 2016 |
| Discovery of selective, noncovalent small molecule inhibitors of DNMT1 as an alternative to traditional DNA hypomethylating agents MB Pappalardi, M Cockerill, JL Handler, A Stowell, K Keenan, CS Sherk, ... Cancer Research 78 (13 Supplement), 2994-2994, 2018 | 9 | 2018 |
| Factors determining the optimal body site and method for obtaining punch biopsies of human skin as a tissue in which to assess pharmacodynamic and pharmacokinetic endpoints in … DR Camidge, MJ Davies, PJ Laud, AL Marshall, M Cockerill, PD Smith, ... Cancer chemotherapy and pharmacology 57 (1), 52-58, 2006 | 3 | 2006 |
| Combination studies in vitro and in vivo with gefitinib (IRESSA) and the MEK 1/2 inhibitor AZD6244 (ARRY142886) M Cockerill, A Logie, G Speake, S Beck, S Cartlidge, PD Smith, ... Clin. Cancer Res 11 (24), 8991S-8991S, 2005 | 2 | 2005 |
| Abstract LB-068: Development of a screening cascade to identify selective small molecule inhibitors of DNMT1 A Stowell, G Thomson, M Cockerill, C Burt, E Fairweather, I Waddell, ... Cancer Research 78 (13 Supplement), LB-068-LB-068, 2018 | 1 | 2018 |
| Development and Evaluation of Selective, Reversible LSD1 Inhibitors from Fragment Start Points A Stowell, N Hamilton, J Blagg, R Burke, S Burns, M Cockerill, ... Molecular Cancer Therapeutics 12 (11), 2013 | 1 | 2013 |
| In vivo evaluation of pharmacodynamic biomarkers and mode of action of AZD6244 (ARRY142886). A Logie, M Cockerill, S Moore, R Jenkins, S Cartlidge, JS McKay, ... CLINICAL CANCER RESEARCH 11 (24), 9024S-9024S, 2005 | 1 | 2005 |
| Discovery of a selective, non-nucleoside small molecule inhibitor of DNA methyltransferase 1 (DNMT1) B King, A Benowitz, J Briand, C Burt, C Carpenter, M Cockerill, K Evans, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256, 2018 | | 2018 |
| Abstract B05: Discovery, validation and targeting of novel synthetic lethal interactions in academic drug discovery HN March, P Chapman, E Blaikley, CA Eberlein, M Cockerill, S Hitchin, ... Molecular Cancer Therapeutics 16 (10 Supplement), B05-B05, 2017 | | 2017 |
| G6PD inhibition and its effects on the radiosensitisation of head and neck squamous carcinoma cells (HNSCC’s) ID Waddell, GV Hopkins, DI James, MJ Cockerill, HF Small, DJ Ogilvie EORTC 2012, 2012 | | 2012 |
| 532 Glucose-6-phosphate Dehydrogenase Inhibition and Its Effects On the Radiosensitization of Head and Neck Squamous Carcinoma Cells GV Hopkins, DI James, MJ Cockerill, HF Small, ID Waddell, DJ Ogilvie European Journal of Cancer 48, 164, 2012 | | 2012 |
