Fred Ledley
Fred Ledley
Center for Integration of Science and Industry, Bentley University
Verified email at - Homepage
Cited by
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Nonviral gene therapy: the promise of genes as pharmaceutical products
FD Ledley
Human gene therapy 6 (9), 1129-1144, 1995
Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation.
KP Ponder, S Gupta, F Leland, G Darlington, M Finegold, J DeMayo, ...
Proceedings of the National Academy of Sciences 88 (4), 1217-1221, 1991
Nucleotide sequence of a full-length complementary DNA clone and amino acid sequence of human phenylalanine hydroxylase
SCM Kwok, FD Ledley, AG DiLella, KJH Robson, SLC Woo
Biochemistry 24 (3), 556-561, 1985
Pharmaceutical approach to somatic gene therapy
FD Ledley
Pharmaceutical research 13 (11), 1595-1614, 1996
Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors
BR Mullin, PH Fishman, G Lee, SM Aloj, FD Ledley, RJ Winand, LD Kohn, ...
Proceedings of the National Academy of Sciences 73 (3), 842-846, 1976
Molecular structure and polymorphic map of the human phenylalanine hydroxylase gene
AG DiLella, SCM Kwok, FD Ledley, J Marvit, SLC Woo
Biochemistry 25 (4), 743-749, 1986
Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases
HE Grenett, FD Ledley, LL Reed, SL Woo
Proceedings of the National Academy of Sciences 84 (16), 5530-5534, 1987
The mouse c-abl locus: molecular cloning and characterization
JYJ Wang, F Ledley, S Goff, R Lee, Y Groner, D Baltimore
Cell 36 (2), 349-356, 1984
In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection
ML Sikes, BW O'Malley Jr, MJ Finegold, FD Ledley
Human gene therapy 5 (7), 837-844, 1994
Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II
M Hinds, K Deisseroth, J Mayes, E Altschuler, R Jansen, FD Ledley, ...
Cancer research 51 (17), 4729-4731, 1991
Extensive restriction site polymorphism at the human phenylalanine hydroxylase locus and application in prenatal diagnosis of phenylketonuria.
AS Lidsky, FD Ledley, AG DiLella, SC Kwok, SP Daiger, KJ Robson, ...
American journal of human genetics 37 (4), 619, 1985
Why pharmacogenomics? Why now?
D Housman, FD Ledley
Nature biotechnology 16 (2), 2-3, 1998
Cloning of full-length methylmalonyl-CoA mutase from a cDNA library using the polymerase chain reaction
R Jansen, F Kalousek, WA Fenton, LE Rosenberg, FD Ledley
Genomics 4 (2), 198-205, 1989
Non-viral gene therapy
FD Ledley
Current Opinion in Biotechnology 5 (6), 626-636, 1994
Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains
FD Ledley, AG DiLella, SCM Kwok, SLC Woo
Biochemistry 24 (14), 3389-3394, 1985
Somatic gene therapy to cells associated with fluid spaces
FD Ledley, BW O'Malley Jr
US Patent 5,770,580, 1998
Gene transfer and expression of human phenylalanine hydroxylase
FD Ledley, HE Grenett, AG DiLella, SC Kwok, SL Woo
Science 228 (4695), 77-79, 1985
GT to AT transition at a splice donor site causes skipping of the preceding exon in phenylketonuria
J Marvit, AG DiLella, K Brayton, FD Ledley, KJH Robson, SLC Woo
Nucleic acids research 15 (14), 5613-5628, 1987
Overexpression of human methylmalonyl CoA mutase in mice after in vivo gene transfer with asialoglycoprotein/polylysine/DNA complexes
J Stankovics, AM Crane, E Andrews, CH Wu, GY Wu, FD Ledley
Human gene therapy 5 (9), 1095-1104, 1994
Contribution of NIH funding to new drug approvals 2010–2016
EG Cleary, JM Beierlein, NS Khanuja, LM McNamee, FD Ledley
Proceedings of the National Academy of Sciences 115 (10), 2329-2334, 2018
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